Article
Gastroenterology & Hepatology
Julian Hercun, Mazen Noureddin, Nabil Noureddin, Jason Eccleston, Daniel Woolridge, T. Jake Liang, Michele Tana, David E. Kleiner, Gracia Viana Rodriguez, Christopher Koh, Jay H. Hoofnagle, Theo Heller
Summary: This study evaluated the involvement of bile duct and disease progression in patients with primary biliary cholangitis (PBC) and found that bile duct injury does not follow the same course as fibrosis, and certain indicators are associated with ductopenia progression.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Kris. V. V. Kowdley, Christopher. L. L. Bowlus, Cynthia Levy, Marlyn. J. J. Mayo, Daniel. S. S. Pratt, Raj Vuppalanchi, Zobair. M. M. Younossi
Summary: Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune liver disease. There have been recent important developments in the diagnosis, treatment, and monitoring of patients with PBC. In this updated expert consensus document, we provide updates on staging, noninvasive prognostic tools, and a treatment algorithm for clinicians managing PBC.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uday Kumar Marri, Prasenjit Das, Shalimar, Mani Kalaivani, Deep Narayan Srivastava, Kumble Seetharama Madhusudhan
Summary: The study demonstrated a strong correlation between the normalized iodine concentration of the liver at 5-minute delayed dual-energy CT and histologic stages of liver fibrosis, indicating good diagnostic performance in estimating liver fibrosis.
Article
Gastroenterology & Hepatology
Christoph Schultheiss, Silja Steinmann, Edith Willscher, Lisa Paschold, Ansgar W. Lohse, Mascha Binder
Summary: This study found that variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share some immunological characteristics. Discriminative markers between AIH and PBC included T and B cell receptor repertoires, as well as soluble immune checkpoint molecules such as sCD25, sLAG-3, sCD86, and sTim-3. Another set of immune factors associated with AIH included TNF, IFN gamma, IL12p70, sCTLA-4, sPD-1, and sPD-L1. Clustering analysis revealed two pathological immunotypes consisting predominantly of either AIH or PBC cases. Overall, variant syndromes may represent an immunological spectrum from PBC to AIH-like disease rather than separate entities.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Xi Li, Yan Li, Jintao Xiao, Huiwen Wang, Yan Guo, Xiuru Mao, Pan Shi, Yanliang Hou, Xiaoxun Zhang, Nan Zhao, Minghua Zheng, Yonghong He, Jingjing Ding, Ya Tan, Min Liao, Ling Li, Ying Peng, Xuan Li, Qiong Pan, Qiaoling Xie, Qiao Li, Jianwei Li, Ying Li, Zhe Chen, Yongxiu Huang, David N. Assis, Shi-Ying Cai, James L. Boyer, Xuequan Huang, Can-E Tang, Xiaowei Liu, Shifang Peng, Jin Chai
Summary: The numbers of DUOX2(+)ACE2(+) small cholangiocytes are inversely associated with disease severity in PBC. They may be the target of pIgR-mediated humoral responses. Protecting these cells and targeting anti-pIgR autoantibodies could be valuable strategies for therapeutic interventions in PBC.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Thomas W. Warnes, Stephen A. Roberts, Alexander Smith, Victor M. Cope, Patricia Vales, Raymond McMahon
Summary: This study found that measurement of baseline portal pressure is of significant prognostic value in primary biliary cholangitis, providing additional predictive information beyond Mayo score and Ludwig stage.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Debashis Haldar, Ashnila Janmohamed, Tim Plant, Matthew Davidson, Hannah Norman, Emily Russell, Olivia Serevina, Kenneth Chung, Kashif Qamar, Bridget Gunson, Bettina Hansen, Alex Richter, Palak J. Trivedi, Gideon M. Hirschfield
Summary: In patients with PBC, the presence of anti-gp210 autoantibodies is associated with adverse clinical manifestations, predicts treatment non-response, and independently predicts decreased transplant-free survival.
LIVER INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Li, Tejasav S. Sehrawat, Jingbiao Chen, Moira B. Hilscher, Kevin J. Glaser, Juan P. Arab, Thiago Milech De Assuncao, Douglas A. Simonetto, Taofic Mounajjed, Armando Manduca, Richard L. Ehman, Vijay H. Shah, Meng Yin
Summary: The bi-parametric dual-frequency hepatic MRE model showed improved diagnostic accuracy for predicting portal hypertension in mouse models, especially in cases of hepatic congestion and cholestatic liver injury. This technical advancement has the potential to monitor PHTN progression and treatment efficacy in the presence of varying fibrosis.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marwa F. Ismail, Gideon M. Hirschfield, Bettina Hansen, Monica Tafur, Khaled Y. Elbanna, Marc H. Goldfinger, Gerard R. Ridgway, Kartik S. Jhaveri
Summary: MRCP+ showed significant associations with biochemical scores and MRE, with its association with biochemical scores comparable to ANALI scores. MRCP+ enhanced the associations of ANALI2 and MRE with the Mayo Risk Score.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lukas Burghart, Emina Halilbasic, Philipp Schwabl, Benedikt Simbrunner, Albert Friedrich Staettermayer, Oleksandr Petrenko, Bernhard Scheiner, David Bauer, Matthias Pinter, Kaan Boztug, Mattias Mandorfer, Michael Trauner, Thomas Reiberger
Summary: In patients with primary biliary cholangitis, features of clinically significant portal hypertension may lead to an increased risk of decompensation and mortality. The combination of LSM and platelets serves as a valuable assessment tool for predicting long-term outcomes.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pediatrics
Xingxing Duan, Liu Yang, Rong Wen, Hong Cao, Huan Wen, Wengang Liu, Hongxia Yuan
Summary: Ultrasound elastography, especially sound touch elastography (STE), is a useful tool for preoperatively assessing liver cirrhosis in infants with biliary atresia (BA). It has a high correlation with the stage of hepatic fibrosis and good diagnostic performance.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Nidhi Jalan-Sakrikar, Abid Anwar, Usman Yaqoob, Can Gan, Anthony B. Lagnado, Alexander Q. Wixom, Diana Jurk, Robert C. Huebert
Summary: This study investigated the mechanistic relationship between telomere damage and biliary fibrosis in primary sclerosing cholangitis (PSC). The results showed telomere attrition and reduced telomerase reverse transcriptase (TERT) expression in patients with PSC. Cellular models demonstrated that telomere dysfunction can lead to senescence and fibrosis, which can be rescued by modulating TERT levels.
Article
Biochemistry & Molecular Biology
Endrit Shahini, Giuseppe Pasculli, Andrea Mastropietro, Paola Stolfi, Paolo Tieri, Davide Vergni, Raffaele Cozzolongo, Francesco Pesce, Gianluigi Giannelli
Summary: This study used a network medicine approach and a drug repurposing strategy to find potential therapeutic drugs for different stages of primary biliary cholangitis (PBC). The results identified several promising drugs targeting distinct stages of PBC.
Article
Gastroenterology & Hepatology
Anca Trifan, Cristina-Maria Muzica, Robert Nastasa, Sebastian Zenovia, Ermina Stratina, Remus Stafie, Adrian Rotaru, Ana-Maria Singeap, Camelia Cojocariu, Catalin Sfarti, Irina Girleanu, Stefan Chiriac, Tudor Cuciureanu, Laura Huiban, Carol Stanciu
Summary: Although liver cirrhosis is associated with high mortality, patients usually have a good quality of life in the compensated phase, and the disease may progress undiagnosed for many years. Vibration-controlled transient elastography with controlled attenuation parameter is a useful noninvasive tool to estimate the severity of fibrosis and steatosis. The study aimed to establish the prevalence of significant liver fibrosis diagnosed by vibration-controlled transient elastography in an apparently healthy population.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Luis Antonio Manzo-Francisco, Jorge Aquino-Matus, Desiree Vidana-Perez, Misael Uribe, Norberto Chavez-Tapia
Summary: This study conducted a meta-analysis to evaluate the performance of transient elastography (TE) compared with liver biopsy in adult patients with primary biliary cholangitis (PBC). The findings showed that TE performed excellently in staging liver fibrosis and ruling out cirrhosis in clinical practice.
ANNALS OF HEPATOLOGY
(2023)