Review
Endocrinology & Metabolism
Milian Chen, Ying Cao, Guang Ji, Li Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) has become a common chronic liver disease worldwide. It is commonly associated with obesity, but can also occur in lean individuals, known as lean NAFLD. Lean NAFLD is often accompanied by sarcopenia, progressive loss of muscle mass and quality. The pathological features of lean NAFLD contribute to the development of sarcopenia, while sarcopenia further exacerbates ectopic fat accumulation and lean NAFLD. In this review, we discuss the association between sarcopenia and lean NAFLD, summarize the underlying pathological mechanisms, and suggest potential strategies to reduce the risks of lean NAFLD and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yun-Cheng Hsieh, Sae Kyung Joo, Bo Kyung Koo, Han-Chieh Lin, Won Kim
Summary: Anthropometric data in association with NAFLD, such as muscle alterations and visceral adiposity assessed by CT, are associated with significant fibrosis. Low skeletal muscle mass and myosteatosis have additive values in predicting significant fibrosis in NAFLD.
LIVER INTERNATIONAL
(2021)
Review
Cell Biology
Qiannan Ren, Qiming Sun, Junfen Fu
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with a high-fat diet. Autophagy plays a protective role in NAFLD, but dysfunction of liver autophagy may contribute to the development of NAFLD.
Article
Gastroenterology & Hepatology
Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Ou-Yang Huang, Rafael S. Rios, Kenneth I. Zheng, Sui-Dan Chen, Hong-Lei Ma, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng
Summary: The relationship between visceral fat accumulation and liver disease severity is influenced by PNPLA3 rs738409 gene polymorphism, particularly the G allele, which increases the risk of liver fibrosis in patients with biopsy-proven NAFLD.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Danijela Ristic-Medic, Marijana Kovacic, Marija Takic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Maja Jovicic, Vesna Vucic
Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.
Review
Gastroenterology & Hepatology
Richie Manikat, Mindie H. Nguyen
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is associated with metabolic syndrome and often presents with comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD is also linked to non-liver comorbidities including cardiovascular disease, chronic kidney disease, and sleep apnea. Managing these comorbidities is crucial for improving liver-related and overall health outcomes in patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Immunology
Wenhui Zhang, Ren Lang
Summary: NAFLD and NASH are significant contributors to liver disease worldwide. Macrophages play a crucial role in the pathogenesis of NAFLD and NASH, and their metabolic characteristics influence their activation state and functionality. Targeting macrophage metabolism could be a promising therapeutic approach for the management of NAFLD/NASH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Jing Liu, Huan Wu, Yan Zhang, Changbao Hu, Dongyu Zhen, Pengcheng Fu, Yanfu He
Summary: Arthrospira platensis phycobiliprotein peptide extracts have potential therapeutic effects in nonalcoholic fatty liver disease (NAFLD) by modulating lipid metabolism and intestinal metabolites, leading to improved hepatic steatosis.
Article
Nutrition & Dietetics
Ye Xu, Xianghui Huang, Bingxin Huangfu, Yanzhou Hu, Jia Xu, Ruxin Gao, Kunlun Huang, Xiaoyun He
Summary: It has been found that dietary intervention with sulforaphane (SFN) can attenuate non-alcoholic fatty liver disease (NAFLD) through the gut-liver axis. SFN protects intestinal integrity by altering gut microbiota composition, enhancing intestinal tight junction protein, and inhibiting intestinal inflammation pathways. This reduces gut-derived endotoxin translocation to the liver and improves NAFLD.
Article
Medicine, General & Internal
Zhipeng Huang, Donghong Wei, Xueping Yu, Zicheng Huang, Yijie Lin, Wenji Lin, Zhijun Su, Jianjia Jiang
Summary: This study provides an integrated description of clinical, metabolic, and influencing factors for non-obese nonalcoholic fatty liver disease (NAFLD) patients. It found that NAFLD patients with a BMI < 28 kg/m(2) and visceral adipose tissue < 100 cm(2) have higher insulin resistance, higher fasting plasma glucose, and a higher metabolic abnormality rate. BMI is the main influencing factor of NAFLD.
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Ningning You, Jiali Xu, Liyan Wang, Lili Zhuo, Jingxin Zhou, Yu Song, Aliaweis Ali, Yan Luo, Jin Yang, Wenjun Yang, Minghua Zheng, Jing Xu, Li Shao, Junping Shi
Summary: The study found that there are significant differences in the gut fungal structure of NAFLD patients, and some fungi may be associated with NAFLD development, liver injury, and lipid metabolism. Therefore, research on gut fungi may have important value for diagnosing and monitoring NAFLD.
Article
Food Science & Technology
Hui Yu, Xiangzhou Yi, Xia Gao, Jun Ji, Zhongyuan Liu, Guanghua Xia, Chuan Li, Xueying Zhang, Xuanri Shen
Summary: The study found that tilapia-head chondroitin sulfate (TH-CS) can be used as an oral supplement to effectively prevent the development of nonalcoholic fatty liver disease (NAFLD). TH-CS can improve liver damage, blood lipid accumulation, and insulin resistance (IR), reduce inflammatory response and oxidative stress, restore gut microbiota balance, and increase the abundance of bacteria producing short-chain fatty acids (SCFAs).
Article
Endocrinology & Metabolism
Min Tao, Guanghong Zhou, Jing Liu, Miao He, Cong Wang, Xie Luo, Lili Zhang
Summary: Observational studies have shown that visceral adipose tissue (VAT) can increase the risk of nonalcoholic fatty liver disease (NAFLD). This study aimed to explore the causal association between VAT and NAFLD using Mendelian randomization. The results provided genetic evidence that higher VAT mass causally associated with a higher risk of NAFLD, suggesting that reducing VAT could be a therapeutic strategy for managing NAFLD.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Nursing
Diego G. D. Christofaro, William R. Tebar, Gabriela C. R. da Silva, Max Duarte Oliveira, Gabriel G. Cucato, Joao Paulo Botero, Marilia A. Correia, Raphael M. Ritti-Dias, Mara C. Lofrano-Prado, Wagner L. Prado
Summary: This study found that during the COVID-19 pandemic, individuals with depressive symptoms were more likely to experience musculoskeletal pain, particularly if they were physically inactive.
PAIN MANAGEMENT NURSING
(2022)
Article
Environmental Sciences
Ricardo Cardoso Cassilhas, Ricardo Augusto Leoni De Sousa, Luciana Caxa, Valter Viana, Romain Meeusen, Fabio Luiz Goncalves, Caique Olegario Magalhaes, Sergio Tufik, Marco Fabricio Dias Peixoto, Renato Sobral Monteiro Junior, Marco Tulio de Mello
Summary: Indoor aerobic exercise, compared to outdoor exercise, results in lower pollution exposure for elderly individuals, leading to improved cognitive function and increased BDNF levels. Additionally, indoor exercise shows significant benefits for glycemic control.
AIR QUALITY ATMOSPHERE AND HEALTH
(2022)
Article
Medicine, Research & Experimental
Emilson Colantonio, Felipe Granado de Souza, Joao Paulo Botero, Neal Malik, Mara Cristina Lofrano-Prado, Adriana Carneiro Lambertucci, Wagner Luiz do Prado
Summary: In this study, the presence of metabolic syndrome in Brazilian adolescents with obesity was 47.76%. The most frequently reported abnormal measurements were waist circumference (100%), blood pressure (85%), and triglycerides (50.75%). Boys with obesity were more likely to meet the criteria for metabolic syndrome compared to girls.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Article
Biology
Lucas Alves Facundo, Valdenio Martins Brant, Renato Carvalho Guerreiro, Henrique de Araujo Andrade, Fernando Mazzilli Louzada, Andressa Silva, Marco Tulio de Mello
Summary: This study aims to describe the sleep regularity of athletes using the Sleep Regularity Index (SRI) and investigate the effects of factors such as sex, competitive level, and sport type on their sleep/wake rhythm. The findings reveal that international level athletes, female athletes, and individual sport athletes have better sleep regularity.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Sandra Maria Chemin Seabra da Silva, Aline de Piano Ganen, Deborah Cristina Landi Masquio, Marcus V. L. Dos Santos Quaresma, Debora Estadella, Lila Missae Oyama, Lian Tock, Marco Tulio de Mello, Ana Raimunda Damaso, Claudia Maria da Penha Oller do Nascimento, Danielle Arisa Caranti
Summary: This study aimed to verify the relationships between serum-free fatty acids (FA), inflammatory processes, and depressive symptoms in obese adolescents. The results showed positive correlations between depressive symptoms and saturated fatty acids (SFA) content, body fat, and inflammatory adipokines. On the other hand, n-3 polyunsaturated fatty acids (PUFA) content was negatively correlated with depressive symptoms. However, further longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Physiology
Adriano A. L. Carmo, Karine N. O. Goulart, Christian E. T. Cabido, Ygor A. T. Martins, Gabriela C. F. Santos, Felipe L. T. Shang, Luciano S. Prado, Danusa D. Soares, Marco T. de Mello, Thiago T. Mendes, Emerson Silami-Garcia, Samuel P. Wanner
Summary: This study investigated the effects of an active warm-up and time-of-day variation on repeated-sprint performance and post-exercise recovery. The results showed that a warm-up improved sprint performance, and sprints performed in the late afternoon were better. Additionally, warm-up also led to faster post-exercise recovery.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Rehabilitation
Isadora Grade, Henrique Andrade, Renato Guerreiro, Eduardo Stieler, Flavia R. da Silva, Hesojy G. V. da Silva, Roberto Vital, Renan A. Resende, Dawit A. P. Goncalves, Andre G. Andrade, Marco T. de Mello, Andressa Silva
Summary: A systematic review found that Paralympic athletes have poor sleep quality and quantity, with high rates of daytime sleepiness. Subjective questionnaires are commonly used to assess their sleep.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Physiology
Marlene Salvina Fernandes da Costa, Vinicius de Oliveira Damasceno, Marco Tulio de Melo, Marcos Andre Moura dos Santos, Wlaldemir Roberto dos Santos, Fernanda Veruska Narciso, Walmir Romario dos Santos, Saulo Fernandes Melo de Oliveira, Pedro Pinheiro Paes
Summary: This study aims to investigate the direct influence of training load on sleep behavior during the tapering phase of training for young swimmers. The results show that there is no significant influence of training load on sleep variables. However, a strong association between total sleep time (TST) and external load (EL) was observed in the irregular sleep group.
REVISTA BRASILEIRA DE MEDICINA DO ESPORTE
(2023)
Article
Allergy
Cinthia Vila Nova Santana, Gabriela Pimentel Pinheiro, Givaneide S. Lima, Jamille Souza Fernandes, Alvaro A. Cruz
Summary: This article presents a case study of a 28-year-old woman who died of asthma despite being initially diagnosed with moderate asthma and prescribed regular treatment. The study highlights the importance of prioritizing asthma in primary health care, including early diagnosis, asthma management, and patient education to identify worsening symptoms and manage exacerbations according to a written asthma plan. This approach may help reduce premature and preventable asthma deaths.
Review
Rehabilitation
Eduardo Stieler, Marco T. de Mello, Ingrid L. B. Lobo, Dawit A. Goncalves, Renan Resende, Andre G. Andrade, Thiago F. Lourenco, Anselmo A. C. Silva, Henrique A. Andrade, Renato Guerreiro, Andressa Silva
Summary: This review examines the methods used to assess external load in Paralympic sports, aiming to provide scientific evidence for multidisciplinary teams to prescribe and monitor athlete's development, enhance performance, and reduce injury/illness risks. The study identified 8 methods to quantify external load in 8 different Paralympic sports and highlights the need for further research to validate the effectiveness and reliability of these methods.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Nutrition & Dietetics
Ronaldo Angelo Dias da Silva, Leszek Antoni Szmuchrowski, Joao Paulo Pereira Rosa, Marcos Antonio Pereira dos Santos, Marco Tulio de Mello, Lucas Savoi, Yves Ferreira Porto, Francisco de Assis Dias Martins, Marcos Daniel Motta Drummond
Summary: Intermittent fasting (IF) is commonly used by combat sports athletes for weight loss but may decrease performance. This study examined the effects of IF on body weight and Taekwondo performance. The results showed that IF led to a decrease in body weight in the first two weeks but stabilized afterwards. Performance in vertical jumping had different patterns in fed and fasted states. Despite the decrease in body weight, IF did not significantly impact performance.
Article
Public, Environmental & Occupational Health
Carla Caroliny de Almeida Santana, Mauro Virgilio Gomes de Barros, Flavio Roberto Carneiro de Medeiros, Joao Francisco Lins Brayner Rangel, Francys Paula Cantieri, Daniela Alarcon, Wagner Luiz do Prado
Summary: This study investigated the association between physical fitness components and academic achievement in a large sample of high school students. The results showed a negative association between cardiorespiratory fitness and academic achievement, as well as a positive association between muscular strength and academic achievement.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Medicine, General & Internal
Wagner Luiz do Prado, Mara Cristina Lofrano-Prado, Diego Giulliano Destro Christofaro, Carla Caroliny de Almeida Santana, Gabriel Grizzo Cucato, Matthew Jackson, Grace Shumate, Sarah Shumate, Marilia de Almeida Correia, Joao Paulo Botero, Raphael Mendes Ritti-Dias
Summary: This study confirmed the association between weight and changes in physical activity levels during the COVID-19 outbreak, and found that individuals with overweight/obesity were more likely to have lower physical activity levels, regardless of sex.
EINSTEIN-SAO PAULO
(2022)
Article
Medicine, General & Internal
Rafael Mathias Pitta, Bruno Gion Cerazi, Luana Queiroga, Raphael Mendes Ritti Dias, Marco Tulio de Mello, Fernando Henpin Yue Cesena, Roberta Luksevicius Rica, Julien Steven Baker, Marcio Sommer, Gabriel Grizzo Cucato, Danilo Sales Bocalini, Oskar Kauffman
Summary: Sitting time and screen time are not directly associated with obstructive sleep apnea (OSA).
SAO PAULO MEDICAL JOURNAL
(2022)
Review
Sport Sciences
Aldo C. Silva, Adriana S. Amaral, Renato Guerreiro, Andressa Silva, Marco T. deMello, Sergio G. daSilva, Leandro Rechenchosky, Wilson Rinaldi
Summary: Sleep patterns and associated factors among elite soccer athletes were examined in this study. The findings indicate that elite soccer athletes often fail to meet the recommended sleep guidelines, which can be influenced by match outcomes and travel.
APUNTS SPORTS MEDICINE
(2022)
