Review
Gastroenterology & Hepatology
Amanda Ricciuto, Martine Aardoom, Esther Orlanski-Meyer, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan Daebritz, Marla Dubinsky, Seamus Hussey, Peter Lewindon, Javier Martin De Carpi, Victor Manuel Navas-Lopez, Marina Orsi, Frank M. Ruemmele, Richard K. Russell, Gabor Veres, Thomas D. Walters, David C. Wilson, Thomas Kaiser, Lissy de Ridder, Dan Turner, Anne M. Griffiths
Summary: Through expert survey and literature review, predictors of poor outcomes in pediatric CD were identified, aiding in the development of treatment algorithms and planning future studies.
Review
Pediatrics
Marleen Bouhuys, Willem S. Lexmond, Patrick F. van Rheenen
Summary: Inflammatory bowel diseases (IBDs) are chronic, immune-mediated disorders that include Crohn's disease and ulcerative colitis. Pediatric onset of the disease occurs in about 10% of cases. The management of pediatric IBD has evolved, with anti-tumor necrosis factor therapy being used upfront for patients at high risk for complications. Biochemical or endoscopic remission is the therapeutic goal, and pediatric IBD comes with unique challenges such as growth impairment and psychological issues. General pediatricians play a crucial role in integrating these challenges in the clinical care of patients with IBD and optimizing their outcomes.
Review
Pediatrics
So Yoon Choi, Ben Kang
Summary: The introduction of biological agents, particularly anti-TNF agents, has significantly improved the long-term prognosis of patients with inflammatory bowel disease (IBD). In pediatric populations, only two biological agents, infliximab (IFX) and adalimumab (ADL), have been approved for use. ADL has shown efficacy in achieving mucosal healing (MH) and histological remission in both naive patients and those who have previously received biologic treatment. Therapeutic drug monitoring may further enhance the effectiveness of ADL treatment and reduce treatment failure.
FRONTIERS IN PEDIATRICS
(2022)
Review
Nutrition & Dietetics
Ugo Cucinotta, Claudio Romano, Valeria Dipasquale
Summary: Genetic and environmental factors play a role in the onset of inflammatory bowel disease (IBD). Diet composition is suspected to have a significant impact on IBD risk. Nutrition and diet play a crucial role in the pathogenesis and course of the disease, with clear links between diet composition and intestinal permeability impairment.
Article
Medicine, General & Internal
Shengnan Wang, Shijian Miao, Xiaoxia Qiu, Jie Wu, Yuhuan Wang
Summary: This study aimed to assess the capability of fecal calprotectin (FC) in predicting small bowel capsule endoscopy (SBCE) findings in pediatric patients with known Crohn's disease (CD). The study found that FC was weakly correlated with small bowel inflammation and can be used as a predictor of small bowel mucosal inflammation.
Article
Pediatrics
Juliane Klamt, Jan de Laffolie, Elisa Wirthgen, Sebastian Stricker, Jan Daebritz
Summary: This study analyzed data of pediatric Crohn's disease patients and confirmed previously suggested risk factors while identifying new ones. Utilizing these risk factors can help better assess individual patient risk and choose appropriate treatment strategies.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pediatrics
Xiaojun Zhuang, Caiguang Liu, Shukai Zhan, Zhenyi Tian, Na Li, Ren Mao, Zhirong Zeng, Minhu Chen
Summary: This systematic review included 41 original studies investigating gut microbiota profiles in pediatric patients with IBD. While some studies reported differences in the abundance of certain bacteria in pediatric patients with IBD compared to those without IBD, inconsistent results and heterogeneous methodologies prevented drawing clear overall conclusions. Further large-sample studies with more rigorous and standardized methodologies are needed.
FRONTIERS IN PEDIATRICS
(2021)
Review
Nutrition & Dietetics
Luca Scarallo, Paolo Lionetti
Summary: The multifactorial etiology of Crohn's Disease (CD), including genetic and environmental factors, is widely acknowledged. Diet plays a significant role in shaping gut microbiota composition and is suspected to contribute to the pathogenesis of inflammatory bowel disease (IBD). Research has focused on dietary therapies for CD management, targeting mucosal inflammation, intestinal dysbiosis, and optimization of nutritional status in pediatric CD patients.
Article
Pharmacology & Pharmacy
Francesca Penagini, Luisa Lonoce, Luisa Abbattista, Valentina Silvera, Giulia Rendo, Lucia Cococcioni, Dario Dilillo, Valeria Calcaterra, Gian Vincenzo Zuccotti
Summary: This review summarizes the most up-to-date literature on pediatric inflammatory bowel diseases (IBDs), including current treatment options and new strategies such as small molecule drugs and combination therapy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Elizabeth A. Spencer, Jean-Frederic Colombel, Ryan C. Ungaro
Summary: Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic, progressive, immune-mediated diseases of adults and children with no cure. Delay in diagnosis is common and associated with adverse outcomes, highlighting the importance of early diagnosis and prompt treatment. Risk stratification based on clinical, demographic, and serologic markers can guide selection of first-line therapy in personalized medicine.
Review
Gastroenterology & Hepatology
Jonathan Van Hecke, Lucas Wauters, Gigi Veereman
Summary: This study collected real-world data of children and adolescents with inflammatory bowel disease and studied their treatment outcomes. The results showed a significant decrease in disease activity after 1 year, with no significant differences between 1-year and 5-year follow-ups.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Maria V. Salguero, Dianne Deplewski, Ranjana Gokhale, Kristen Wroblewski, Timothy Sentongo, Aseel Jan, Barbara S. Kirschner
Summary: This study investigated the impact of age at menarche on growth in pediatric patients with inflammatory bowel disease. The results showed that early age at menarche was associated with greater potential for growth. Surgery, jejunal disease, hospitalization, parental height, and weight were factors associated with growth impairment.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Immunology
Paulina Krawiec, Elzbieta Pac-Kozuchowska
Summary: The study showed a significant increase in serum cathelicidin levels in children with Crohn's disease and ulcerative colitis, regardless of disease activity. Additionally, there was a negative correlation between cathelicidin and fecal calprotectin, suggesting a differing role of these molecules in the pathophysiology of pediatric ulcerative colitis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Sara Salvador-Martin, Alejandra Melgarejo-Ortuno, Luis A. Lopez-Fernandez
Summary: The use of biological drugs in pediatric inflammatory bowel disease has shown significant improvements, and predicting response to these drugs is particularly valuable in children. Clinical, biochemical, and genetic parameters can potentially predict response to biological drugs in children with IBD.
Review
Psychiatry
Nathalie Touma, Caroline Varay, Carolina Baeza-Velasco
Summary: This systematic review examined the determinants of quality of life and psychosocial adjustment to pediatric Crohn's disease. The findings indicate that disease activity and parental stress are strong predictors, while factors such as abdominal pain, negative illness perceptions, and internalizing symptoms also play a role in impacting outcomes.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Daryoush Samim, Damien Choffat, Peter Vollenweider, Gerard Waeber, Pedro Marques-Vidal, Marie Mean
Summary: The point prevalence of atrial fibrillation (AF) and AF + atrial flutter (AFL) in the city of Lausanne (Switzerland), assessed between 2014 and 2017, was low but increased with age and in men.
Article
Cardiac & Cardiovascular Systems
Melanie Rochat, Benoit Delabays, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Francois Mach, Julien Vaucher
Summary: A study using data from a 10-year follow-up of a population-based cohort found that the management of dyslipidemia, especially in secondary prevention and in women, is suboptimal. According to the guidelines from the European Society of Cardiology and the American Heart Association/American College of Cardiology, a low proportion of eligible participants were using statins, and the achievement rate of low-density lipoproteins cholesterol target levels was also low. Additionally, women were less likely to receive high-intensity treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Roxane de La Harpe, Christian W. Thorball, Claire Redin, Stephane Fournier, Olivier Mueller, Davide Strambo, Patrik Michel, Peter Vollenweider, Pedro Marques-Vidal, Jacques Fellay, Julien Vaucher
Summary: This study aimed to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores. The results showed that combining a polygenic risk score with clinical risk scores significantly improved risk reclassification for patients with intermediate risk for cardiovascular disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Obstetrics & Gynecology
Zayne Milena Roa-Diaz, Faina Wehrli, Irene Lambrinoudaki, Catherine Gebhard, Iris Baumgartner, Pedro Marques-Vidal, Arjola Bano, Peter Francis Raguindin, Taulant Muka
Summary: The aim of this study was to evaluate the association between early natural menopause and changes in cardiovascular risk factors (CVRFs). Postmenopausal women from the Swiss CoLaus study were included in the analysis. The study found that early menopause may be associated with changes in glucose metabolism, but has little impact on other CVRFs.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Nutrition & Dietetics
Filipa Vicente, Marcela Holanda, Renata Ramalho, Joa Mendes, Pedro Marques-Vidal, Paula Pereira
Summary: The aim of this study was to determine whether young gymnasts were consuming adequate amounts of nutrients, particularly calcium and iron. The results showed that Portuguese gymnasts consume a high amount of ultra-processed items and a low amount of calcium and iron, despite having a sufficient macronutrient distribution.
Article
Psychiatry
Geoffroy Solelhac, Mathieu Berger, Marie-Pierre F. Strippoli, Nicola Andrea Marchi, Aurelie Stephan, Jean-Marie Petit, Virginie Bayon, Theo Imler, Jose Haba-Rubio, Tifenn Raffray, Peter Vollenweider, Pedro Marques-Vidal, Gerard Waeber, Damien Legar, Francesca Siclari, Pierre A. Geoffroy, Martin Preisig, Raphael Heinzer
Summary: This study aimed to investigate the sleep differences between different subtypes of major depressive disorder (MDD). The study found that current melancholic MDD was associated with decreased sleep quality and increased wake after sleep onset, while remitted unspecified MDD was associated with increased rapid eye movements density.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Valeriya Chekanova, Nazanin Abolhassani, Julien Vaucher, Pedro Marques-Vidal
Summary: This study assessed the importance of clinical and genetic factors in the management of dyslipidaemia in the general population. It found that the management of dyslipidaemia in Switzerland is suboptimal, and the use of high potency statins is hindered by low posology. The use of genetic risk scores in the management of dyslipidaemia is not recommended.
Article
Cardiac & Cardiovascular Systems
Vassilios S. Vassiliou, Vasiliki Tsampasian, Ana Abreu, Donata Kurpas, Elena Cavarretta, Martin O'Flaherty, Zoe Colombet, Monika Siegrist, Delphine De Smedt, Pedro Marques-Vidal
Summary: This paper discusses practical approaches to improving nutrition in various cardiovascular settings, including primary care, cardiac rehabilitation, sports medicine, paediatric cardiology, and public health. It emphasizes the importance of nutrition assessment, individualized nutritional plans, and the use of technology in promoting healthier dietary habits. The paper also highlights the significance of nutritional counseling in managing familial hypercholesterolaemia and congenital heart disease, and suggests the implementation of policies to promote healthy eating.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Abdullah Alkandari, Julien Vaucher, Pedro Marques-Vidal
Summary: This study assessed the trends in glycemic, blood pressure, and cholesterol control in adults with diabetes in Switzerland over a 15-year period. The findings showed improvements in these control measures, but there is still room for further improvement.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biology
Olga Trofimova, Adeliya Latypova, Giulia DiDomenicantonio, Antoine Lutti, Ann-Marie G. de Lange, Matthias Kliegel, Silvia Stringhini, Pedro Marques-Vidal, Julien Vaucher, Peter Vollenweider, Marie-Pierre F. Strippoli, Martin Preisig, Ferath Kherif, Bogdan Draganski
Summary: MRI data from over 1000 participants between the ages of 46 and 87 reveals that cardiovascular risk factors are associated with myelin loss and neuroinflammation in the brain. Associations between CVRFs and white matter microstructure were observed predominantly in limbic and prefrontal tracts. Moderate-to-vigorous physical activity was linked to higher myelin content independently of CVRFs.
COMMUNICATIONS BIOLOGY
(2023)
Article
Health Care Sciences & Services
Alexandre Gouveia, Charlene Mauron, Pedro Marques-Vidal
Summary: The study shows that potentially avoidable hospitalizations (PAH) for asthma and COPD in Switzerland have increased from 1998 to 2018, resulting in a significant burden and economic costs for the country.
Article
Cardiac & Cardiovascular Systems
Ko Ko Maung, Pedro Marques-Vidal
Summary: This study assessed the impact of the COVID-19 pandemic on cardiovascular disease hospitalizations, interventions, and mortality in Switzerland. The results showed a reduction in cardiovascular disease admissions and interventions, an increase in total cardiovascular disease deaths, and a change in seasonal patterns.
Article
Nutrition & Dietetics
Pedro Marques-Vidal, Piotr Jankowski, Zeljko Reiner, Dirk De Bacquer, Kornelia Kotseva
Summary: This study assessed the dietary changes made by individuals at high risk of cardiovascular disease in different European countries and found that less than 60% of participants reported being on a specific diet, with significant variations between countries.
CLINICAL NUTRITION ESPEN
(2023)
Article
Cardiac & Cardiovascular Systems
Magda Gamba, Zayne M. Roa-Diaz, Peter Francis Raguindin, Marija Glisic, Arjola Bano, Taulant Muka, Oscar H. Franco, Pedro Marques-Vidal
Summary: A diet high in phytochemical-rich foods, assessed through the dietary phytochemical index (DPI), is associated with lower waist circumference, body mass index, insulin, leptin, and hs-CRP values, as well as reduced odds of central obesity. This highlights the potential protective effect of phytochemical intake on cardiometabolic risk factors and emphasizes the importance of consuming high levels of phytochemical-rich foods for promoting overall metabolic health.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Sureka Nagarajah, Abdullah Alkandari, Pedro Marques-Vidal
Summary: This study confirmed the association between most published GRS and diabetes, but no consistent association between GRS and diabetes control was found. Using GRS to manage patients with T2DM in clinical practice is not justified.
DIABETOLOGY & METABOLIC SYNDROME
(2023)