Review
Pharmacology & Pharmacy
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Jae-Woo Park
Summary: This study assessed the methodology and quality of evidence of systematic reviews (SRs) on the use of herbal medicines (HMs) for irritable bowel syndrome (IBS). The findings suggest that HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence were generally low. Well-designed randomized controlled trials are needed to better evaluate the safety and efficacy of HM in IBS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Hwan-Su Jung, Jae-Woo Park
Summary: This overview aims to provide data on the safety and efficacy of herbal medicines for treating irritable bowel syndrome (IBS) based on qualitative and quantitative syntheses of systematic review data. The study will compare the effects of herbal medicines with a placebo, no treatment, usual care, or conventional treatment to evaluate their efficacy and safety for IBS treatment.
Review
Pharmacology & Pharmacy
Hui Zheng, Song Jin, Yin-Li Shen, Wen-Yan Peng, Kun Ye, Tai-Chun Tang, Jun Zhao, Min Chen, Zhi-Gang Li
Summary: This study found that Chinese herbal medicine is effective in relieving IBS symptoms but may cause a higher rate of adverse events compared to placebo. The findings were confirmed through trial sequential analysis with sufficient information size.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Zulun Zhang, Qianqian Li, Sheng Zhang, Yujie Liu, Gaochen Lu, Quan Wen, Bota Cui, Fuquan Zhang, Faming Zhang
Summary: This study aimed to evaluate the efficacy of washed microbiota transplantation (WMT) on sleep disturbances, and psychological and gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). The results showed significant improvements in sleep quality, anxiety, depression, gastrointestinal symptoms, and IBS severity after WMT. Baseline sleep duration scores were identified as an independent predictive factor for sleep improvement.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Article
Plant Sciences
Nian Liu, Jilei Li, Yichong Wang, Shengsheng Zhang
Summary: This study compared the efficacy and safety of different Chinese herbal medicine (CHM) therapies for diarrhea-predominant irritable bowel syndrome (IBS-D). The results showed that Jianpiwenshen Therapy (JPWS) and Shuganjianpiwenshen Therapy (SGJP) were the most effective CHM therapies for IBS-D, improving clinical symptoms and reducing adverse events.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Lukasz Wiklendt, Reizal Mohd Rosli, Raghu Kumar, Niranchan Paskaranandavadivel, Peter A. Bampton, Lyn Maslen, Marcello Costa, Simon J. Brookes, Greg O'Grady, Phil G. Dinning
Summary: Patients with IBS-D have altered colonic motility and reduced prevalence of the retrograde cyclic motor pattern compared with healthy adults. The reduction in retrograde propagation may lead to premature rectal filling and result in postprandial urgency and diarrhea.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Review
Integrative & Complementary Medicine
Guan-ru Chen, Xiao-fang Xie, Cheng Peng
Summary: Irritable bowel syndrome (IBS) is a common and difficult-to-treat disease, and Chinese medicine has shown remarkable efficacy and advantages in its treatment. This review summarizes the literature on the treatment of IBS with Chinese medicine, highlighting the latest treatment methods and underlying mechanisms. The primary methods of Chinese medicine treatment for IBS are herbal prescriptions, acupuncture, and moxibustion, with potential mechanisms involving the regulation of the enteric nervous system, alleviation of visceral hypersensitivity, stability of intestinal flora, and regulation of the immune system.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Review
Nutrition & Dietetics
Daniela Pop, Radu Samuel Pop, Dorin Farcau
Summary: This paper discusses the benefits of peppermint oil, STW5, psyllium fiber, Curcuma, ginger, and other herbal medicines in pediatric patients with irritable bowel syndrome, based on findings in the current literature.
Article
Multidisciplinary Sciences
Agata Furgala, Katarzyna Ciesielczyk, Magdalena Przybylska-Felus, Konrad Jablonski, Krzysztof Gil, Malgorzata Zwolinska-Wcislo
Summary: This study aimed to assess the postprandial response, including gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant irritable bowel syndrome (IBS-C). The results showed that IBS-C patients had significantly elevated preprandial levels of gastrin and insulin, while VIP and ghrelin levels were decreased. Moreover, the gastric motility was impaired in IBS-C patients. These findings suggest that disturbances in the postprandial concentration of gut peptides may contribute to abnormal gastric function and intestinal motility, leading to exacerbation of clinical symptoms in IBS patients.
SCIENTIFIC REPORTS
(2023)
Review
Gastroenterology & Hepatology
Zarina Mamieva, Elena Poluektova, Valery Svistushkin, Vasily Sobolev, Oleg Shifrin, Francisco Guarner, Vladimir Ivashkin
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with incompletely understood etiology. Dysbiosis of the gut microbiota and antibiotic use are closely associated with the development of IBS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Uday C. Ghoshal
Summary: Postinfection IBS (PI-IBS) is a subset of patients developing new onset IBS following acute gastroenteritis, with a prevalence rate of 11.5%. Various factors are associated with the development of PI-IBS, suggesting a potential organic basis. More studies are needed to explore the treatment of PI-IBS, as randomized controlled trials are rare.
Article
Integrative & Complementary Medicine
Shehanshah Wali Moazzam, Abdul Mobeen, Mansoor Ahmad Siddiqui
Summary: This study demonstrates that Jawarish Shahi (JS) has a safe and effective effect on the symptoms of irritable bowel syndrome (IBS), making it a viable alternative or complementary treatment for IBS.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)