Article
Endocrinology & Metabolism
Yuta Tanizaki, Yuki Shibata, Hongen Zhang, Yun-Bo Shi
Summary: The study demonstrates a close relationship between TR alpha-regulated T3 activation of the cell cycle program and larval epithelial cell death and adult epithelial stem cell development during intestinal remodeling in Xenopus tropicalis metamorphosis.
Article
Oncology
Yurong Lu, Yuqing Zhao, Penggang Liu, Xiulong Xu
Summary: B-Raf kinase inhibitors such as vemurafenib induce stemness-related gene expression and promote self-renewal of thyroid cancer stem cells by activating the sonic hedgehog pathway transcription factor Gli1. Inhibitors of the hedgehog pathway significantly reduce the expression of stemness-related genes in thyroid cancer cells, enhancing the anti-tumor activity of B-Raf kinase inhibitors when used in combination. Targeting both B-Raf and the hedgehog pathway may help overcome drug resistance in thyroid cancer.
ENDOCRINE-RELATED CANCER
(2023)
Article
Endocrinology & Metabolism
Yuta Tanizaki, Lingyu Bao, Bingyin Shi, Yun-Bo Shi
Summary: The thyroid hormone T3 plays a crucial role in vertebrate development, cellular processes, and metabolism through the T3 receptor (TR) pathway. In this study, researchers used Xenopus tropicalis animals lacking a functional SRC3 gene to demonstrate the important role of SRC3 in intestinal remodeling during postembryonic development. The findings show that SRC3 is a critical component of the TR-signaling pathway in vivo during intestinal remodeling, particularly affecting adult intestinal stem cell proliferation and larval epithelial cell apoptosis.
Review
Endocrinology & Metabolism
Yuta Tanizaki, Yuki Shibata, Wonho Na, Yun-Bo Shi
Summary: Amphibian metamorphosis, especially in anurans like Xenopus laevis and Xenopus tropicalis, is a valuable model to study how T3 regulates adult organ development due to its similarity to mammalian postembryonic development and its independence from maternal influence. Studies on intestinal remodeling have provided important insights into the molecular mechanisms of T3 regulation of cell fate during development, suggesting that T3-induced activation of the cell cycle program is crucial for larval epithelial cell death and the formation of adult intestinal stem cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Ayumu Tsubosaka, Daisuke Komura, Miwako Kakiuchi, Hiroto Katoh, Takumi Onoyama, Asami Yamamoto, Hiroyuki Abe, Yasuyuki Seto, Tetsuo Ushiku, Shumpei Ishikawa
Summary: The stomach is an important digestive organ with various functions, and its cellular biology is not yet fully understood. In this study, the researchers used single-cell RNA sequencing and subcellular-level transcriptomics analysis to construct the largest dataset of the human stomach to date. They discovered a new stem cell marker, LEFTY1, and identified various cell-cell interactions between epithelial and stromal cells.
Article
Biochemical Research Methods
Ha Young Lee, Celine DG. Abueva, Andrew Padalhin, So Young Park, Hyun Seok Ryu, Phil-Sang Chung, Hee Jung Kim, Jeongyun Kim, Seung Hoon Woo
Summary: This study explored the effects of photobiomodulation (PBM) on Sonic hedgehog (Shh) signaling as a potential method for preserving and regenerating taste. Primary taste cells were treated with a Shh antagonist and irradiated with a 630 nm light-emitting diode. The study found that PBM treatment successfully upregulated Shh protein expression, regenerated taste buds, and restored taste function.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Neurosciences
Isidora Paredes, Jose Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin, Carmen Ruiz de Almodovar
Summary: Bidirectional crosstalk between neural and vascular compartments plays a critical role in oligodendrocyte precursor cell specification, with neural progenitor cells expressing angiopoietin-1 and endothelial cells producing transforming growth factor beta 1 in response. This collaboration demonstrates the complex relationship between NPCs and the vasculature in regulating oligodendrogenesis.
NATURE NEUROSCIENCE
(2021)
Article
Oncology
Yurong Lu, Yiwen Zhu, Shihan Deng, Yuhuang Chen, Wei Li, Jing Sun, Xiulong Xu
Summary: The Sonic Hedgehog (Shh) pathway plays a crucial role in regulating thyroid cancer stem cell self-renewal, with inhibition of this pathway showing potential in preventing tumor initiation driven by thyroid cancer stem cells.
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Kazuo Kishi
Summary: The expression of sonic hedgehog (Shh) is involved in the regeneration of texture during wound healing, especially in epidermal keratinocyte migration and division.
Article
Endocrinology & Metabolism
Risheng Ma, Syed A. Morshed, Rauf Latif, Terry F. Davies
Summary: The study introduced a new mouse thyroid injury model by inducing the expression of Diphtheria Toxin Receptor in TPO-expressing thyroid cells, leading to severe thyroid damage in mice. However, after discontinuing the toxin administration, the thyroid quickly recovered through the activation of stem cell markers and the involvement of both stem and progenitor cells in regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Neurosciences
Daniel Treisman, Yinghua Li, Yuan Zhu
Summary: While most SHH-MBs respond well to therapeutic intervention, radiation therapy can cause long-term neurocognitive defects, particularly in infants and young children. Attempts to reduce therapy or de-escalate treatment have shown poor outcomes in infant SHH-MBs, potentially due to the existence of therapy-resistant cancer-stem-cell populations driving tumor recurrence.
NEUROMOLECULAR MEDICINE
(2022)
Article
Oncology
Li Li, Jing Zhao, Quanbao Zhang, Yifeng Tao, Conghuan Shen, Ruidong Li, Zhengyu Ma, Jianhua Li, Zhengxin Wang
Summary: This study demonstrated that HCC cells secrete Shh via exosomes to promote tumorigenesis through the activated Hedgehog pathway. The expression of Shh via exosomes is associated with later tumor stages and higher recurrence rates in liver cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Wan-shuang Cao, Meng-jiu Zhao, Yue Chen, Jian-yun Zhu, Chun-feng Xie, Xiao-ting Li, Shan-shan Geng, Cai-yun Zhong, Jin-yan Fu, Jie-shu Wu
Summary: This study found that low-dose exposure to phthalates (PAE) can promote the stem cell properties of breast cancer stem cells (BCSCs) through the regulation of ANp63 alpha and the Sonic Hedgehog (SHH) signaling pathway. The importance of this study lies in revealing the mechanism of PAE exposure on BCSCs and providing a theoretical basis for further investigation of the lowest observed effect concentrations of PAE and its relevance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Marion Thauvin, Rodolphe Matias de Sousa, Marine Alves, Michel Volovitch, Sophie Vriz, Christine Rampon
Summary: Reactive oxygen species (ROS), including hydrogen peroxide (H2O2), play a crucial role in cell signaling. In zebrafish fin regeneration, the interaction between H2O2 and Sonic hedgehog (Shh) is studied, with H2O2 controlling Shh expression and Shh regulating the H2O2 level. This interaction changes during different stages of the regenerative program.
JOURNAL OF CELL SCIENCE
(2022)
Article
Cell Biology
Jianmin Liu, Jing Yin, Ping Chen, Daoquan Liu, Weixiang He, Yan Li, Mingzhou Li, Xun Fu, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Summary: The study revealed that the SMO cascade is upregulated in BPH tissues, and inhibiting SMO can induce cell apoptosis, cause cell cycle arrest, and reduce tissue fibrosis markers. The GLI gene family is positively correlated with clinical parameters, suggesting that the SMO cascade may play an important role in the development of BPH.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Luan Wen, Takashi Hasebe, Thomas C. Miller, Atsuko Ishizuya-Oka, Yun-Bo Shi
CELL AND BIOSCIENCE
(2015)
Article
Cell Biology
Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita, Atsuko Ishizuya-Oka
CELL AND TISSUE RESEARCH
(2016)
Article
Cell & Tissue Engineering
Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita, Liezhen Fu, Yun-Bo Shi, Atsuko Ishizuya-Oka
Article
Cell & Tissue Engineering
Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita, Atsuko Ishizuya-Oka
Article
Biology
Yuto Sakane, Midori Iida, Takashi Hasebe, Satoshi Fujii, Daniel R. Buchholz, Atsuko Ishizuya-Oka, Takashi Yamamoto, Ken-ichi T. Suzuki
Article
Anatomy & Morphology
Takashi Hasebe, Mitsuko Kajita, Liezhen Fu, Yun-Bo Shi, Atsuko Ishizuya-Oka
DEVELOPMENTAL DYNAMICS
(2012)
Article
Endocrinology & Metabolism
Guihong Sun, Rachel A. Heimeier, Liezhen Fu, Takashi Hasebe, Biswajit Das, Atsuko Ishizuya-Oka, Yun-Bo Shi
Article
Physiology
Masakazu Fujiwara, Takashi Hasebe, Mitsuko Kajita, Atsuko Ishizuya-Oka, Mohammad Ghazizadeh, Oichi Kawanami
JOURNAL OF VASCULAR RESEARCH
(2011)
Article
Multidisciplinary Sciences
Thomas C. Miller, Guihong Sun, Takashi Hasebe, Liezhen Fu, Rachel A. Heimeier, Biswajit Das, Atsuko Ishizuya-Oka, Yun-Bo Shi
Article
Multidisciplinary Sciences
Jun Fujii, Maho Kodama, Akira Oike, Yasuki Matsuo, Mi-Sook Min, Takashi Hasebe, Atsuko Ishizuya-Oka, Koichi Kawakami, Masahisa Nakamura
Article
Multidisciplinary Sciences
Atsuko Ishizuya-Oka, Mitsuko Kajita, Takashi Hasebe
Article
Biochemistry & Molecular Biology
Takashi Hasebe, Liezhen Fu, Thomas C. Miller, Yu Zhang, Yun-Bo Shi, Atsuko Ishizuya-Oka
CELL AND BIOSCIENCE
(2013)
Article
Endocrinology & Metabolism
Takashi Hasebe, Kenta Fujimoto, Daniel R. Buchholz, Atsuko Ishizuya-Oka
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Takashi Hasebe, Kenta Fujimoto, Atsuko Ishizuya-Oka
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Takashi Hasebe, Kenta Fujimoto, Atsuko Ishizuya-Oka
Summary: Recent research has shown that the Hippo signaling pathway plays an important role in intestinal remodeling during amphibian metamorphosis. This study found that the expression of genes involved in the Hippo pathway is regulated by thyroid hormone (TH) in the metamorphosing intestine of Xenopus laevis. The transcriptional co-activator YAP1, a major effector of the Hippo signaling, is expressed in adult stem cells and surrounding connective tissue cells. The interaction between YAP1 and its binding partner TEAD1 is inhibited by verteporfin (VP), and this inhibition leads to decreased stem cell number and proliferation, resulting in the failure of adult epithelial development.
CELL AND TISSUE RESEARCH
(2022)