期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 80, 期 2, 页码 154-158出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2014.06.010
关键词
Klebsiella pneumoniae carbapenemease; Enterobacter cloacae; Enterobacter aerogenes
资金
- National Institutes of Health [R21AI107302, R01AI104895]
Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A bla(KPC)-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of bla(KPC) in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes. (C) 2014 Elsevier Inc. All rights reserved.
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