Article
Microbiology
Binayak Rimal, Hunter R. Batchelder, Elizabeth Story-Roller, Chandra M. Panthi, Chavis Tabor, Eric L. Nuermberger, Craig A. Townsend, Gyanu Lamichhane
Summary: T405, a beta-lactam antibiotic of the penem subclass, exhibited bactericidal activity against Mycobacteroides abscessus (Mob) infection in a mouse model, comparable to imipenem. It also showed synergism when combined with imipenem, cefditoren, or avibactam against Mob in vitro. Furthermore, a scheme for industrial-scale synthesis and purification of T405 was described. These findings make T405 a promising candidate for further preclinical assessment to treat Mob disease.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Mo Kwok, Katie L. Heard, Anthony May, Rachel Pilgrim, Jonathan Sandoe, Sarah Tansley, Jennifer Scott
Summary: The study aims to identify and summarize the health outcomes of penicillin allergy testing (PAT) in children. The results show that PAT can effectively delabel allergies and improve tolerance to penicillin use in children. However, there is a lack of research on outcomes related to disease burden, which requires further investigation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Timothy N. Luxton, Natalie King, Christoph Walti, Lars J. C. Jeuken, Jonathan A. T. Sandoe
Summary: Adjusting dosing regimens based on carbapenem levels may improve patient exposure to carbapenems. However, there is limited research on the impact of carbapenem therapeutic drug monitoring (TDM) on health outcomes and antimicrobial resistance (AMR). Further optimization and standardization of TDM practices are needed.
Review
Infectious Diseases
Sang -Ho Choi, Antoni Cesar, Timothy Arthur Chandos Snow, Naveed Saleem, Nishkantha Arulkumaran, Mervyn Singer
Summary: For hospitalized adults with mild-to-moderate community-acquired pneumonia (CAP), respiratory fluoroquinolone monotherapy or β-lactam plus macrolide combination therapy are suggested as first-line options according to guidelines. However, the efficacy of these regimens has not been adequately evaluated.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Lara Munoz-Munoz, Jose A. Ainsa, Santiago Ramon-Garcia
Summary: This study evaluated the in vitro activity of various beta-lactam antibiotics against Mycobacterium kansasii (Mkn), a tuberculosis-like lung infection. Penicillins plus clavulanate and first- and third-generation cephalosporins were found to be the most active beta-lactams against Mkn. Combinatorial time-kill assays also showed favorable interactions of amoxicillin-clavulanate and cefadroxil with the standard Mkn treatment, making them potential alternative options for Mkn therapy.
Article
Microbiology
Victor H. Ruiz, Andrew Fratoni, David P. Nicolau, Joseph L. Kuti
Summary: Pseudomonas aeruginosa is a common multidrug-resistant pathogen in patients with cystic fibrosis (CF). Imipenem/relebactam retains susceptibility against most isolates, possibly due to the potentiation effect of relebactam on imipenem.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Joao Goncalves Pereira, Joana Fernandes, Ana Rita Duarte, Susana Mendes Fernandes
Summary: Prescribing antimicrobial drugs in critically ill patients is a complex challenge due to the need to balance infection treatment and toxicity prevention. Real-time dose adjustments are crucial, especially in individual and interindividual contexts. Continuous infusion and therapeutic monitoring could enhance efficacy, but more evidence is needed. Special populations present additional challenges in selecting the right dose, with intermittent use further complicating dosing. Recent research links overexposure to toxicity, mitochondrial and microbiome changes.
Article
Infectious Diseases
Pimsumon Jiamboonsri, Chatchakorn Eurtivong, Sompit Wanwong
Summary: This study found that methyl gallate (MG) can synergize with beta-lactam antibiotics to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Additionally, gallic acid (GA) and MG were found to induce morphological changes in MRSA.
Article
Infectious Diseases
Tawanda Gumbo, Carleton M. Sherman, Devyani Deshpande, Jan-Willem Alffenaar, Shashikant Srivastava
Summary: The study found that adding faropenem to a linezolid plus pyrazinamide backbone regimen has a slow sterilizing effect on Mycobacterium tuberculosis and is unlikely to shorten therapy duration. Furthermore, the efficacy of these combination regimens against drug-resistant tuberculosis needs further investigation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Yuki Igarashi, Wataru Takemura, Xiaoxi Liu, Nana Kojima, Takumi Morita, Victor Tuan Giam Chuang, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto
Summary: This study aimed to determine the target pharmacokinetics (PK) and pharmacodynamics (PD) values of CFPM/NAC in mice infected with beta-lactamase-producing Enterobacterales. The results indicate that fT > MICi is a suitable PK/PD parameter for monitoring the CFPM/NAC combination, with a minimum target value of 30% for achieving a static effect against beta-lactamase-producing Enterobacterales.
PHARMACEUTICAL RESEARCH
(2023)
Article
Microbiology
Dongxu Sun, Ruslan Tsivkovski, Joe Pogliano, Hannah Tsunemoto, Kirk Nelson, Debora Rubio-Aparicio, Olga Lomovskaya
Summary: Xeruborbactam is a cyclic boronate inhibitor with direct antibacterial activity against some Gram-negative bacteria, and enhances the potency of beta-lactam antibiotics. It exhibits unique effects on different pathogens such as Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae, effectively inhibiting the growth of resistant strains.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Bjorn Asheim Hansen, Nils Grude, Morten Lindbaek, Tore Stenstad
Summary: This study clarifies the efficacy and safety of pivmecillinam (PIV) used as step-down therapy for bacteremic urinary tract infection (UTI).
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G. Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair MacGowan, Sally Grier, Julie Gibbs, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L. Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesus Rodriguez-Bano, Isabel Morales, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez Martinez, Eva M. Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstein, Leonard Leibovici, Dafna Yahav
Summary: A multicentre retrospective study found no mortality advantage with combination therapy over monotherapy for Pseudomonas aeruginosa bacteraemia. There were no differences in clinical failure, microbiological failure, adverse events, and resistance development between the two treatment regimens. Further randomized controlled trials are needed to confirm these findings.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Chemistry, Inorganic & Nuclear
Micha Zabiszak, Justyna Frymark, Kazuma Ogawa, Monika Skrobanska, Martyna Nowak, Renata Jastrzab, Malgorzata T. Kaczmarek
Summary: Beta-lactam antibiotics are widely used in medicine due to their strong antibacterial activity. They are produced by fungi and bacteria, and their advantages lie in their potent bactericidal activity and wide spectrum of activity. The common mode of action of beta-lactam antibiotics involves inhibiting the synthesis of the bacterial cell wall, leading to the demise of the bacterial cell.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Infectious Diseases
Dagmar Hildebrand, Jana Boehringer, Eva Koerner, Ute Chiriac, Sandra Foermer, Aline Saehr, Torsten Hoppe-Tichy, Klaus Heeg, Dennis Nurjadi
Summary: This study investigates the potential effect of cefiderocol on the barrier function of vascular endothelial cells. The results suggest that cefiderocol can reduce the permeability of intercellular gaps and decrease the release of inflammatory cytokines.
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)