Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Xin-Yi Yu, Zhao-Qiang Zhang, Jia-Chang Huang, Jia-Yu Lin, Xue-Pei Cai, Chu-Feng Liu
Summary: This study investigated the combined effect of human periodontal ligament cells (hPDLCs) and interleukin (IL)-7 on CD4(+)T cells, as well as the effect of IL-7 on the immunomodulatory properties of hPDLCs. The results showed that IL-7 promoted proliferation and inhibited apoptosis in hPDLCs, leading to the polarization of CD4(+)T cells into Treg cells but had no significant effect on Th17 cell differentiation.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chengyi Huang, Fucheng Zhang, Peng Li, Cai Song
Summary: Microglia activation, increased IL-6 and decreased TGF-beta are observed in depressed patients or animal models of depression. This study found imbalances between IL-6 and TGF-beta and between Th17 and Treg in a mouse model of depression, and IL-2 treatment restored these imbalances and improved depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
Summary: Intraperitoneally delivered mesenchymal stem cells (MSCs) secrete THBS1 to boost IL-10(+)Bregs and control the progression and recurrence of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Junying Wang, Xingqi Zhao, Yisong Y. Wan
Summary: Balanced immunity is crucial for maintaining health and homeostasis. CD4(+) helper T (Th) cells play a central role in regulating immune tolerance and immune rejection. Regulatory T (Treg) and Th17 cells are important cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. Understanding the regulation of Treg and Th17 cell function by the TGF-beta superfamily and its signaling pathways is of great importance for both health and disease.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Editorial Material
Immunology
Jane H. Buckner, Oliver J. Harrison
Summary: Th17 cells play crucial roles in host-microbe interactions and can also contribute to chronic inflammation and tissue pathology. This study reveals that intestinal Th17 cells serve as a reservoir for pathogenic Th17 cells during severe tissue inflammation.
TRENDS IN IMMUNOLOGY
(2022)
Article
Biology
Ruixue Li, Renyong Wang, Shijie Zhong, Farhan Asghar, Tiehan Li, Lei Zhu, Hong Zhu
Summary: The study demonstrated the strong immunosuppressive effect of TGF-beta 1/MSCs in vitro, showing that they can lower the proportion of CD4(+) CD8(+) T cells and increase the proportion of CD4(+) CD25(+) T cells, while regulating the expression of IL-10, IL-17A, IL-21, and IL-22. The immunosuppressive effect of TGF-beta 1/MSCs is mediated by interferon-gamma (IFN-gamma).
OPEN LIFE SCIENCES
(2021)
Article
Immunology
Stephanie Musiol, Francesca Alessandrini, Constanze A. Jakwerth, Adam M. Chaker, Evelyn Schneider, Ferdinand Guerth, Benjamin Schnautz, Johanna Grosch, Ileana Ghiordanescu, Julia T. Ullmann, Josephine Kau, Mirjam Plaschke, Stefan Haak, Thorsten Buch, Carsten B. Schmidt-Weber, Ulrich M. Zissler
Summary: TGF-beta plays a critical role in allergic airway inflammation by driving effector T cells and influencing the disease outcome. Inhibiting TGF-beta can reduce the disease phenotype, decrease pro-inflammatory T cell frequencies, and increase anti-inflammatory T cell frequencies. Additionally, in patients with allergic rhinitis and asthma, allergen-specific immunotherapy can suppress Th2 and Th9 cell frequencies and decrease the secretion of TGF-beta and IL-9.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lekha Rani, Anil Kumar, Juilee Karhade, Garima Pandey, Adrita Guha, Gyan C. Mishra, Mohan R. Wani
Summary: IL-3 inhibits the differentiation of Th17 cells and promotes the development of Treg cells, regulating the pathogenesis of rheumatoid arthritis. IL-3 treatment significantly decreases the pathogenic Th17 cell responses and arthritic scores.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Asad, Abdus Sabur, Mohd Kamran, Md Shadab, Sonali Das, Nahid Ali
Summary: The study reveals the important role of IL-17 in the progression of Leishmania donovani infection in a murine model of VL, and highlights the regulatory functions of CD4(+)CD25(+) T cells and their secretion of TGF-beta and IL-35 in modulating IL-17 levels during chronic VL.
Article
Immunology
Qi Zhang, Yiping Lu, Fangwei Liu
Summary: IL-10-producing B cells were found to modulate the inflammatory response induced by 1,3-beta-glucan, and their modulation pattern might be influenced by Treg cells.
IMMUNOLOGY LETTERS
(2021)
Article
Plant Sciences
Xiao-Lu Jie, Zi-Rui Luo, Jin Yu, Zhe-Ren Tong, Qiao-Qiao Li, Jia-Hui Wu, Yi Tao, Pei-Shi Feng, Ji-Ping Lan, Ping Wang
Summary: The study found that PPRFT can protect the lungs by reducing oxidative stress, airway inflammation, and lung tissue damage in asthma. PPRFT also regulates the imbalance of Th17/Treg cell ratios, suppresses RORγt expression, and increases the expression of IL-10 and Foxp3 in the lung. Furthermore, PPRFT treatment inhibits IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Zhenhua Deng, Jinren Zhou, Xiaoxin Mu, Jian Gu, Xiangyu Li, Qing Shao, Jinyang Li, Chao Yang, Guoyong Han, Jie Zhao, Yongxiang Xia
Summary: The co-infusion of hAMSC and Treg was found to prevent liver fibrosis, with Treg improving the function of hAMSC by regulating the TGF-β-IDO signaling. This provides a promising approach for treating liver cirrhosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Farhad Seif, Zahra Torki, Hamidreza Zalpoor, Mehran Habibi, Majid Pornour
Summary: T cells play a crucial role in tumor development and anti-tumor responses in breast cancer patients. The cytokines in the tumor microenvironment can influence the differentiation and function of T cells, thereby affecting breast cancer treatment. This review discusses the factors that affect T cell differentiation in breast cancer, as well as the related clinical trials.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Gastroenterology & Hepatology
Ling-Ling Huang, Xue-Ping Yu, Ju-Lan Li, Hui-Ming Lin, Na-Ling Kang, Jia-Ji Jiang, Yue-Yong Zhu, Yu-Rui Liu, Da-Wu Zeng
Summary: The study evaluated the diagnostic value of the FibroScan device in assessing liver fibrosis stage in chronic HBV-infected patients and found that liver inflammation affects the accuracy of FibroScan. A non-invasive model was established to predict the risk of misdiagnosis of fibrosis stage using FibroScan.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Yue Li, Xiao-Hong Dai, Xue-Ping Yu, Wei Zou, Wei Teng, Peng Liu, Xin-Yang Yu, Qi An, Xin Wen
Summary: The study investigated the prophylactic impact of scalp acupuncture therapy on autologous blood injection murine models of intracerebral hemorrhage (ICH) and found that it could mitigate secondary damage following ICH by moderating ferroptosis, reducing iron sequestration, improving mitochondrial health in nerve cell bodies, and suppressing neuronal ferroptosis. The effects were associated with amplified expression of p62, Nrf2, GPX4 and FTH1, decreased expression of Keap1, and upregulation of FTH1 and GPX4, ultimately leading to enhanced recovery after ICH through the antioxidant pathway and mitigation of lipid peroxidation insults arising from ferroptosis.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Jian Sun, Xueping Yu, Zhangyan Weng, Lei Jin, Jian Yang, Huatang Zhang, Jun Gu, Ni Wang, Jianghua Yang
Summary: Hepatotoxic drugs are closely associated with the development of organ failure and ACLF among patients with acute deterioration of HBV-CLD, leading to reduced 90-day survival rates.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Na-Ling Kang, Qing-Fa Ruan, De-Sheng Zhang, Xue-Ping Yu, Zhen-Ting Hu, Zhi-Min Lin, Lu-Ying Wu, Meng-Xin Lin, Zu-Xiong Huang, Jia-Ji Jiang, Yu-Rui Liu, Ri-Cheng Mao, Da-Wu Zeng
Summary: The study aimed to examine the diagnostic value of APRI and FIB-4 in chronic HBV carriers with different ULNs for ALT. The GPSA model showed a higher diagnostic value for liver fibrosis in different carrier groups.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Microbiology
Xueping Yu, Yang Yu, Jialiang Ouyang, Haixia Wen, Hongting Wang, Xin Ma
Summary: This report presents the whole-genome sequence of Lactobacillus acidophilus LA-10A, which was isolated from fermented mare's milk. This strain has gained popularity due to its remarkable effectiveness in treating and preventing Helicobacter pylori infection. The genome sequence of LA-10A provides valuable molecular insights into its characteristics.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Virology
Xueping Yu, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Jian Sun, Milong Su, Huatang Zhang, Minhui Zheng, Zhipeng Huang, Wenwu Lin, Richeng Mao, Jiming Zhang, Chunfu Zheng, Zhijun Su
Summary: CD3(+)CD4(-)CD7(+)CD57(-) T cells are decreased in patients with end-stage liver disease, especially those with acute to chronic liver failure, and this decrease is associated with disease severity, prognosis, and complications. IL-22 stimulation promotes apoptosis and reduces the number of CD3(+)CD4(-)CD7(+)CD57(-) T cells. These cells exhibit an immunosuppressive phenotype and low expression levels of cytokines.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Nutrition & Dietetics
Xu Zhou, Yafang Chen, Xin Ma, Yang Yu, Xueping Yu, Xiaoyong Chen, Huayi Suo
Summary: In this study, the laxative effect of Bacillus coagulans BC01 was investigated in a functional constipation mouse model. The results showed that BC01 significantly increased intestinal propulsion rate and fecal water content in mice, and it alleviated constipation by regulating gastrointestinal motility, gene expression, intestinal inflammation, and the intestinal microbiota composition. The high-dose BC01 treatment had the best preventive effect on constipation.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Huatang Zhang, Wenhuang Chen, Xiaoyi Ye, Yongjun Zhou, Yijuan Zheng, Zhangyan Weng, Jianfeng Xie, Kuicheng Zheng, Zhijun Su, Xibin Zhuang, Xueping Yu
Summary: This study aimed to investigate the clinical features of patients infected with novel coronavirus wild strains, Delta variant strains, and Omicron variant strains. The predominant clinical types were the novel coronavirus wild strain and Delta strain. Patients infected with the Omicron strain were mainly asymptomatic. Significant differences were found in various blood parameters among the three groups. Patients infected with the Omicron strain in Quanzhou presented with mild symptoms and had few comorbidities and a good prognosis, but the negative conversion time of the new coronavirus nucleic acid was still considerably long.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Xueping Yu, Jian Sun, Feifei Yang, Richeng Mao, Zhiqing Shen, Lan Ren, Songhua Yuan, Qian He, Linxia Zhang, Yu Yang, Xiangqing Ding, Yongquan He, Haoxiang Zhu, Zhongliang Shen, Mengqi Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Summary: This study found that the proportion of granulocytic myeloid-derived suppressor cells (gMDSC) increased significantly in patients with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and this increase was associated with disease severity, prognosis, and infection. Further experiments revealed that TNF-alpha induced gMDSC expansion and inhibited T cell proliferation and interferon-gamma production through the IDO signaling pathway. These findings have important implications for understanding the pathogenesis of HBV-ACLF and developing potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ling-Ling Huang, Xue-Ping Yu, Qing-Fa Ruan, Yan-Xue Lin, Huan Li, Wen Jin, Rui-Feng Liu, Yan-Lan Liang, Yu-Rui Liu, Yue-Yong Zhu, Jia-Ji Jiang, Ri-Cheng Mao, Da-Wu Zeng
Summary: This study aimed to investigate the relationship between liver stiffness measurement (LSM) and liver inflammation in chronic hepatitis B (CHB) patients with different upper limits of normal (ULNs) for alanine aminotransferase (ALT). The results showed that LSM values increased with increasing inflammation, and LSM had a high diagnostic accuracy for significant and severe inflammation. Furthermore, LSM could predict liver inflammation and guide antiviral therapy for CHB patients with normal ALT.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Qiao Ke, Xueping Yu, Xuan Wang, Jinfa Huang, Biding Lin, Jian He, Zhiyong Wang, Xinhui Huang, Xiadi Weng, Yubin Jiao, Yixing Xie, Weimin Wu, Linbin Qiu, Ling Li, Zhengju Xu, Zhijun Su, Yuzhen Zhuge, Jingfeng Liu, Wuhua Guo
Summary: Spontaneous portosystemic shunt (SPSS) is common in patients with hepatitis B-related cirrhosis and is associated with severe liver damage and a higher prevalence of decompensated events such as esophageal and gastric variceal bleeding, portal vein thrombosis, and hepatic encephalopathy.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medicine, General & Internal
Zhipeng Huang, Donghong Wei, Xueping Yu, Zicheng Huang, Yijie Lin, Wenji Lin, Zhijun Su, Jianjia Jiang
Summary: This study provides an integrated description of clinical, metabolic, and influencing factors for non-obese nonalcoholic fatty liver disease (NAFLD) patients. It found that NAFLD patients with a BMI < 28 kg/m(2) and visceral adipose tissue < 100 cm(2) have higher insulin resistance, higher fasting plasma glucose, and a higher metabolic abnormality rate. BMI is the main influencing factor of NAFLD.
Proceedings Paper
Geosciences, Multidisciplinary
Xiayang Xiao, Xueping Yu, Haipeng Wang
Summary: This paper proposes a centroid network detection method for aircraft detection in synthetic aperture radar (SAR) image. By combining geographic coordinate information and subscene classification, the method can accurately and efficiently detect aircrafts located in airports.
2022 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS 2022)
(2022)
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
