Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children in the ESBL group were more likely to have a history of recent antibiotic use or prophylactic antibiotic use and experience recurrent UTIs. Most children with fUTI experience clinical improvement regardless of the choice of antibiotic.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children with a history of recent antibiotic use or prophylactic antibiotic use and recurrent UTIs were more likely to have fUTI caused by ESBL-producing bacteria. Regardless of the choice of antibiotic, most children with fUTI experienced clinical improvement.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Kelly C. Gamble, Dusten T. Rose, Julia Sapozhnikov
Summary: The study aimed to evaluate the clinical outcomes of oral step-down antibiotics compared with continued intravenous therapy in non-bacteremic urinary tract infections. The results showed no significant difference between the two treatment groups in terms of clinical failure, readmission rate, and other outcomes. However, the switch group was associated with reduced hospital length of stay and antibiotic costs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Immunology
Hiroki Namikawa, Waki Imoto, Koichi Yamada, Yoshihiro Tochino, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis identified predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) bacteremia. Previous antimicrobial therapy, neutropenia, nosocomial infection, rapidly fatal underlying disease, respiratory tract infection, Pitt bacteremia score, severe sepsis, and urinary tract infection were found to be predictors of mortality. Appropriate empirical therapy was identified as a protective factor against mortality.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Public, Environmental & Occupational Health
Karyom Djim-Adjim-Ngana, Brunel W. Mbiakop, Leila A. Oumar, Hermann Munshili L. Njifon, Cedric Tchinda Fossi, Elisee L. Embolo Enyegue, Mohamed Mouiche M. Mouliom, Simeon P. Fodouop Chegaing, Louis Deweerdt, Nicolas Njintang Yanou, Julien A. Nguinkal
Summary: This study retrospectively determined the prevalence of multi-drug resistant ESBL strains isolated from UTIs in Northern Cameroon and evaluated the effectiveness of the ATB UR Gallery of BioMerieux in diagnosing ESBL-E. The study found high levels of drug resistance and diverse patterns of antibiotic resistance in ESBL-E strains. These findings emphasize the importance of implementing appropriate treatment guidelines and antimicrobial stewardship measures to prevent the spread and impact of multi-drug resistant strains on public health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Parasitology
Omar Mohammad Khalifeh, Mohammad M. Obaidat
Summary: This study investigates the virulence potential of ESBL-producing E. coli isolates from various sources and finds that these isolates carry multiple virulence genes, posing a potential threat to human health.
Review
Emergency Medicine
Ralphe Bou Chebl, Mohamad Assaf, Nadim Kattouf, Samer Abou Arbid, Saadeddine Haidar, Mirabelle Geha, Maha Makki, Hani Tamim, Gilbert Abou Dagher
Summary: The prevalence of ESBL organisms in urinary tract infections was found to be 24.9%. Predictors of an ESBL UTI infection included antibiotic use in the last 90 days and a history of ESBL producing isolate at any site in the previous year. Based on these findings, modifying initial empiric antibiotic treatment for UTI patients with these risk factors could be considered.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Chen Shang, Run Yang, Ya Yang, Haomin Zhang, Jianjun Zhang, Qiang Xia, Yuan Gao, Yuxiao Deng
Summary: This study investigated the colonization rate, subsequent infections, and clinical outcomes of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in liver transplantation (LT) recipients. The results showed that ESBL-E colonization was not associated with ESBL-E infection or increased risk of ESBL-GNB infection. Furthermore, ESBL-E colonization did not lead to worse prognoses when compared with non-colonized patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Guojing Wang, Yu Zhu, Shana Feng, Baojun Wei, Yujuan Zhang, Jingzhi Wang, Shengkai Huang, Shengling Qin, Xuan Liu, Bing Chen, Wei Cui
Summary: The study aimed to investigate the prevalence and risk factors of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae related urinary tract infections (UTI) in adult cancer patients. The results showed that tumor metastasis, urological cancer, indwelling catheter, and surgery or invasive manipulation were independent risk factors for ESBL UTI. Therefore, clinicians should be alert to the occurrence of ESBL UTI, especially for patients with urological cancer or metastatic tumors, and take necessary measures to prevent and treat such infections.
BMC INFECTIOUS DISEASES
(2023)
Article
Microbiology
Dagninet Alelign, Aschalew Kidanewold
Summary: The study identified a significant number of multidrug-resistant ES beta L and carbapenemase-producing Enterobacteriaceae in street foods, suggesting they may be a potential source of multidrug-resistant foodborne infections. Regular examinations of street food items and tracking medication resistance trends are essential.
Article
Immunology
Daniel T. Anderson, Benjamin Albrecht, K. Ashley Jones, Jesse T. Jacob, Mary Elizabeth Sexton, Zanthia Wiley, William C. Dube, Benjamin Lee, Sujit Suchindran
Summary: A retrospective cohort study found that noncarbapenem beta-lactam (NCBL) treatment for ESBL urinary tract infections (UTIs) had similar or even better outcomes compared to carbapenem treatment in terms of hospital length of stay, clinical and microbiological response, duration of therapy, and rate of relapsed infections.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Karzan Taha Abubaker, Khanda Abdulateef Anwar
Summary: This study investigated the prevalence of antibiotic resistance patterns and integron classes among bacterial isolates in patients with urinary tract infections in Sulaimani, Iraq. The results showed that most bacterial isolates from patients with UTI produced class I and II integrons genes with favourable ESBL properties.
Article
Obstetrics & Gynecology
Yun-sun Choi, Jin-Ha Kim, Yejin Kim, Hye Jung Cho, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Yae-Jean Kim, Cheong-Rae Roh
Summary: This study investigated the epidemiological changes in extended-spectrum lactamase-producing Enterobacteriaceae (ESBL-E) vaginal colonization in high-risk pregnant women and identified independent risk factors. Additionally, the study analyzed the differences in perinatal outcomes according to maternal ESBL-E vaginal colonization.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Immunology
Isabelle Vock, Lisandra Aguilar-Bultet, Adrian Egli, Pranita D. Tamma, Sarah Tschudin-Sutter
Summary: Majority of infections in hospitalized patients colonized with ESBL-PE are not caused by ESBL-PE. Site of infection and patient-level exposures may serve as useful predictors for nESBI,-PE infections, potentially guiding empiric treatment recommendations.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)