期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 69, 期 3, 页码 326-334出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2010.10.029
关键词
ESBL; AmpC; E. coli
资金
- Natural Sciences and Engineering Research Council
The national prevalence of extended-spectrum beta-lactamase (ESBL)-producing (2007: 3.4%, 2008: 4.9%, 2009: 4.3%) and AmpC beta-lactamase (AmpC)-producing (2007: 0.8%, 2008: 3.2%, 2009: 2.7%) Escherichia coli in Canadian hospitals have fluctuated from 2007 to 2009. Rates of co-resistance to non lactam agents are elevated, and multidrug-resistant (MDR) phenotype were observed among E. coli strains producing ESBLs (83.3% MDR) and AmpCs (31.0%). The majority (>98%) of isolates remained susceptible to colistin, tigecycline, amikacin, and the carbapenems. CMY-2 encoding gene was detected in 52.9% of AmpC-producing strains, while bla(CTX-M-15) (65.2%) was the predominant ESBL genotype. A total of 50.3% of ESBL-producing E. coli and 21.4% of AmpC producers belonged to the ST131 clone. In conclusion, ESBL- and AmpC-producing E. coli are established in Canadian hospitals; and although the prevalence rates of these isolates remain low, they are often MDR and associated with the ST131 clone. (C) 2011 Elsevier Inc. All rights reserved.
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