期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 69, 期 1, 页码 114-116出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2010.08.014
关键词
Bis-indole; Multidrug-resistant; MBX; Susceptibility; In vitro
资金
- Veterans Affairs Merit Review Program
- National Institutes of Health
- Geriatric Research Education and Clinical Center VISN 10
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072219] Funding Source: NIH RePORTER
The in vitro activity of 5 novel Microbiotix bis-indole agents (MBXs) (Microbiotix, Worcester, MA) against 30 multidrug-resistant (MDR) Acinetobacter baumannii (including 18 resistant to carbapenems) was evaluated. Overall, MIC(90)'s ranged from 1 to 8 mu g/mL, whereas those for imipenem were >64 mu g/mL. MBX 1196 was the most potent (MIC(90), 1 mu g/mL). MBXs are compounds that are highly effective against MDR A. baumannii. (C) 2011 Elsevier Inc. All rights reserved.
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