期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 68, 期 3, 页码 312-314出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2010.06.009
关键词
Extended-spectrum beta-lactamase; Klebsiella pneumoniae; Tigecycline
Optimal antimicrobial therapy for infections due to ertapenem-resistant Enterobacteriaceae remains undetermined. In this study, a diabetic patient with recurrent pyomyositis and osteomyelitis caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae developed ertapenem resistance after imipenem/cilastatin treatment, which was a currently recommended therapy. He was finally treated successfully using tigecycline. Ertapenem resistance was in part explained by the production of SHV-type ESBL and the absence of an outer membrane protein, OmpK36. Our observation suggests that tigecycline may be an alternative for invasive infections caused by ESBL-producing Enterobacteriaceae with decreased susceptibility to carbapenem. (C) 2010 Elsevier Inc. All rights reserved.
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