期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 63, 期 3, 页码 302-308出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2008.11.012
关键词
Community-acquired respiratory tract infections; Antibacterial surveillance; Telithromycin; Streptococcus pneumoniae; Haemophilus influenzae
资金
- Sanofi-aventis (Paris, France)
- Pfizer
- Altana
- GlaxoSmithKline
The activity of telithromycin and comparator antibacterials was examined in isolates of Streptococcus pneumoniae and Haemophilus influenzae isolated from patients with community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), or sinusitis during year 5 (2003-2004) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin global resistance surveillance study. Among S. pneumoniae, penicillin nonsusceptibility and erythromycin resistance were 35.7% and 36.0%, respectively. beta-Lactamase was produced by 12.3% of H. influenzae isolates. beta-Lactamase-negative ampicillin-resistant strains, mainly from Japan, comprised 5.2% of global H. influenzae isolates. Telithromycin and levofloxacin were the most active agents tested against S. pneumoniae and H. influenzae (> 99% of isolates susceptible) isolated from patients with CAP, AECB, or bacterial sinusitis. Amoxicillin-clavulanate, levofloxacin, and telithromycin were the most active agents against multidrug-resistant S. pneumoniae. (c) 2009 Elsevier Inc. All rights reserved.
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