Article
Microbiology
Silke Huber, Miriam A. Knoll, Michael Berktold, Reinhard Wuerzner, Anita Brindlmayer, Viktoria Weber, Andreas E. Posch, Katharina Mrazek, Sarah Lepuschitz, Michael Ante, Stephan Beisken, Dorothea Orth-Hoeller, Johannes Weinberger
Summary: Whole genome sequencing is a useful tool for monitoring resistance mechanisms in bacteria. This retrospective study found that the major resistance mechanisms in linezolid-resistant Staphylococcus epidermidis (LRSE) were mutations in 23S rRNA and the presence of the cfr gene, with most LRSE isolates showing high resistance levels to linezolid. Linezolid usage was identified as the main factor contributing to the development of resistance, and monitoring of the cfr gene in LRSE and restriction of linezolid usage are potential key steps to reduce resistance and transmission.
Editorial Material
Medicine, General & Internal
Guy Thwaites, Nhung Nguyen
Summary: The development of a highly effective oral 6-month regimen for the treatment of multidrug-resistant tuberculosis is a significant achievement in tuberculosis research. The Nix-TB study demonstrated that a combination of bedaquiline, pretomanid, and linezolid resulted in a favorable outcome in 90% of patients after 6 months.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
Grace Kaul, Abdul Akhir, Manjulika Shukla, Kundan S. Rawat, Chandra P. Sharma, Komal G. Sangu, Haridas B. Rode, Atul Goel, Sidharth Chopra
Summary: Nitazoxanide exhibits potent activity against clinical drug-resistant S. aureus and Enterococcus spp., concentration-dependent killing, ability to eradicate S. aureus biofilm, and lack of generation of resistance in S. aureus. Nitazoxanide synergizes strongly with linezolid against linezolid-susceptible and -resistant S. aureus, showing superior activity compared to untreated control and drug-alone treatment groups, both in vitro and in vivo.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
S. Luque, W. Hope, L. Sorli, R. Munoz-Bermudez, N. Campillo, J. Barcelo-Vidal, F. Alvarez-Lerma, J. P. Horcajada, J. R. Masclans-Enviz, M. Neely, S. Grau
Summary: This study aimed to develop a population pharmacokinetic model of linezolid for individualized dosing. Results showed that the recommended dose of linezolid might need to be four times higher than the maximum licensed dose to achieve a PTA >= 90% for all susceptible isolates. The final PK model was used to develop software for dosage individualization, which accurately tracked patients and may be a useful tool for real-time adjustment of linezolid dosages.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Physics, Applied
P. Walch, B. Mahieu, L. Arantchouk, Y. -B. Andre, A. Mysyrowicz, A. Houard
Summary: The study shows that at high repetition rates, femtosecond lasers can create a permanent low-density channel in air, affecting the breakdown voltage between two electrodes, with the accumulation of O-2 ions being a contributing factor to the voltage reduction.
APPLIED PHYSICS LETTERS
(2021)
Article
Automation & Control Systems
Gunasekaran Raja, Selvam Essaky, Aishwarya Ganapathisubramaniyan, Yashvandh Baskar
Summary: The Industrial Internet of Things (IIoT) is a new industrial 4.0 paradigm that combines IoT, robotics, cyber-physical systems, and other future industrial advancements. Unmanned aerial vehicles (UAVs), part of the IIoT infrastructure, have a significant potential for civil and military purposes. Through the artificial intelligence of things (AIoT), a well-organized group of UAVs outperforms a single large UAV in terms of device scalability, maintenance, and expense.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2023)
Article
Microbiology
Jian Du, Jingtao Gao, Yanhong Yu, Qingfeng Li, Guanghong Bai, Wei Shu, Mengqiu Gao, Yuhong Liu, Lu Wang, Yufeng Wang, Zhongtan Xue, Fengmin Huo, Liang Li, Yu Pang
Summary: In this retrospective study in China, researchers aimed to determine the prevalence of linezolid resistance among MDR-TB patients, monitor changes in linezolid susceptibility during treatment, and explore molecular mechanisms of resistance. They found that 6.9% of patients had linezolid resistance, with a higher rate in those previously exposed to the drug. The most common genetic mutation conferring resistance was a Cys154Arg substitution in the ribosomal protein L3.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Francesca Conradie, Tatevik R. R. Bagdasaryan, Sergey Borisov, Pauline Howell, Lali Mikiashvili, Nosipho Ngubane, Anastasia Samoilova, Sergey Skornykova, Elena Tudor, Ebrahim Variava, Petr Yablonskiy, Daniel Everitt, Genevieve H. H. Wills, Eugene Sun, Morounfolu Olugbosi, Erica Egizi, Mengchun Li, Alda Holsta, Juliano Timm, Anna Bateson, Angela M. M. Crook, Stella M. M. Fabiane, Robert Hunt, Timothy D. D. McHugh, Conor D. D. Tweed, Salah Foraida, Carl M. M. Mendel, Melvin Spigelman
Summary: The study enrolled 181 participants with 84% to 93% achieving favorable outcomes across all four bedaquiline-pretomanid-linezolid treatment groups, with the group receiving 600 mg of linezolid daily for 26 weeks reporting fewer adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Anouk Decuypere, Robin Bauwens, Mieke Audenaert
Summary: This study examines the impact of leader psychological need satisfaction on employees, highlighting the importance of leader competence for employee satisfaction, while also noting a possible negative effect of leader autonomy need satisfaction on employee competence need satisfaction.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Ning Yang, Hui Chen, Xue Li, Ming-Yue Yu, Xiao-Hua Frank Wang
Summary: Drawing on social influence theory, this study examines the relationship between leader status and team performance, and finds that leader popularity plays a mediating role in this relationship, which is moderated by leader narcissism.
CURRENT PSYCHOLOGY
(2023)
Review
Chemistry, Medicinal
Wei Chong Gan, Hien Fuh Ng, Yun Fong Ngeow
Summary: Mycobacteria, including Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria, are intrinsically resistant to many antibiotics and can develop multidrug resistance. Linezolid, an oxazolidinone, was added to the treatment options for drug-resistant mycobacteria, but the emergence of linezolid resistance is a growing concern. Most linezolid-resistant strains show mutations in ribosomal or related genes, with non-ribosomal mechanisms being rare. This review provides an overview of the genetic determinants of linezolid resistance in mycobacteria, aiming to facilitate the discovery of new therapeutic approaches to combat drug resistance.
Article
Infectious Diseases
Michael Timmermans, Bert Bogaerts, Kevin Vanneste, Sigrid C. J. De Keersmaecker, Nancy H. C. Roosens, Carole Kowalewicz, Guillaume Simon, Maria A. Argudin, Ariane Deplano, Marie Hallin, Pierre Wattiau, David Fretin, Olivier Denis, Cecile Boland
Summary: Linezolid-resistant (LR) isolates were widely found in food-producing animals in Belgium, with higher rates in pigs and veal calves. Whole genome sequencing (WGS) revealed LR determinants in a diverse range of isolates, some of which posed a risk to human health due to their close relatedness to human isolates.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Business
Cristian A. Vasquez, Hector P. Madrid, Karen Niven
Summary: This study suggests that leader interpersonal emotion regulation motives have a significant impact on the relationship quality between group members and leaders. Egocentric motives may lead to negative effects, while prosocial motives can mitigate these negative impacts.
JOURNAL OF ORGANIZATIONAL BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Lulu Zhang, Weifeng Yang, Yajun Chu, Bo Wen, Yungchi Cheng, Tariq Mahmood, Mei Bao, Feng Ge, Li Li, Jianfeng Yi, Chengqiang Du, Cheng Lu, Yong Tan
Summary: The combination of linezolid and reyanning mixture shows synergistic inhibitory effect on MRSA and its biofilm, reducing antibiotic concentration and improving biofilm structure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Business
Guanglei Zhang, Huaying Wang, Mingze Li
Summary: The effects of leader narcissism on employee outcomes have inconsistent results, as it may depend on situational cues to activate leader narcissistic traits. This study proposes that perceived goal congruence between leaders and followers can activate leader narcissistic tendencies, negatively affecting leader effectiveness, employee performance, and employee creativity. The findings provide a response to contradictory research and have implications for theory and practice.
JOURNAL OF BUSINESS RESEARCH
(2023)
Article
Rheumatology
Ayano Kelly, Kathleen Tymms, Maarten de Wit, Susan J. Bartlett, Marita Cross, Therese Dawson, Mary De Vera, Vicki Evans, Michael Gill, Geraldine Hassett, Irwin Lim, Karine Manera, Gabor Major, Lyn March, Sean O'Neill, Marieke Scholte-Voshaar, Premarani Sinnathurai, Daniel Sumpton, Armando Teixeira-Pinto, Peter Tugwell, Bart van den Bemt, Allison Tong
ARTHRITIS CARE & RESEARCH
(2020)
Article
Infectious Diseases
Leonard R. Duncan, Caitlin J. Smith, Robert K. Flamm, Rodrigo E. Mendes
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Review
Rheumatology
Alyssa Howren, J. Antonio Avina-Zubieta, Joseph H. Puyat, John M. Esdaile, Deborah Da Costa, Mary A. De Vera
ARTHRITIS CARE & RESEARCH
(2020)
Article
Microbiology
Mariana Castanheira, Timothy B. Doyle, Valerie Kantro, Rodrigo E. Mendes, Dee Shortridge
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
E. Wenzler, K. M. Meyer, S. C. Bleasdale, M. Sikka, R. E. Mendes, K. L. Bunnell, M. Finnemeyer, S. L. Rosenkranz, L. H. Danziger, K. A. Rodvold
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Rheumatology
Alyssa Howren, Nicole W. Tsao, Hyon K. Choi, Kam Shojania, Alison Kydd, Russell Friesen, J. Antonio Avina-Zubieta, Mary A. De Vera
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Nevena Rebic, Eric C. Sayre, Enav Z. Zusman, Neda Amiri, Corisande Baldwin, Mary A. De Vera
Review
Rheumatology
Ayano Kelly, Luke Crimston-Smith, Allison Tong, Susan J. Bartlett, Charlotte L. Bekker, Robin Christensen, Mary A. De Vera, Maarten de Wit, Vicki Evans, Michael Gill, Lyn March, Karine Manera, Robby Nieuwlaat, Shahrzad Salmasi, Marieke Scholte-Voshaar, Jasvinder A. Singh, Daniel Sumpton, Karine Toupin-April, Peter Tugwell, Bart van den Bemt, Suzanne Verstappen, Kathleen Tymms
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Oncology
Ameer Farooq, Carl J. Brown, Eric C. Sayre, Manoj J. Raval, Jonathan M. Loree, Ria Garg, Mary A. De Vera
Summary: The study found that young colorectal cancer patients did not have higher healthcare utilization than individuals without the disease in the years leading up to their diagnosis, except for the year before diagnosis, indicating a potential window for earlier diagnosis.
Review
Oncology
Niki Oveisi, Vicki Cheng, Ursula Ellis, Stuart Peacock, Helen McTaggart-Cowan, Lori A. Brotto, Jonathan Loree, Gillian E. Hanley, Sharlene Gill, Meera Rayar, Amirrtha Srikanthan, Mary A. De Vera
Summary: This systematic review and meta-analysis examined the impacts of cancer on reproductive health outcomes in adolescents and young adults (AYAs) aged 15-39 years. The analysis included 21 studies and assessed 62 reproductive outcomes. The results showed that AYA cancer patients have a higher risk of preterm birth, gestational diabetes, and use of fertility treatment compared to controls, especially among those who received radiation.
Review
Oncology
Vicki Cheng, Niki Oveisi, Helen McTaggart-Cowan, Jonathan M. M. Loree, Rachel A. A. Murphy, Mary A. A. De Vera
Summary: Research suggests that there is an association between colorectal cancer (CRC) and mental health disorders, particularly anxiety and depression. This systematic review and meta-analysis aimed to evaluate the incidence of anxiety and depression among patients with CRC. The results showed a significant association between CRC and depression, indicating an increased risk of depression after CRC diagnosis. Predictors of anxiety and depression among CRC patients included clinical characteristics, cancer treatment, and sociodemographic characteristics. The impacts of anxiety and depression in CRC patients included increased mortality and decreased quality of life.
Review
Oncology
Anastasia Kalyta, Mary A. De Vera, Stuart Peacock, Jennifer J. Telford, Carl J. Brown, Fergal Donnellan, Sharlene Gill, Jonathan M. Loree
Summary: Colorectal cancer is the third most commonly diagnosed cancer in Canada, with recent data showing rising incidence rates in people under 50. Similar trends in the United States have led to recommendations for screening to begin at age 45 instead of 50. Epidemiologic changes in Canada suggest earlier screening initiation may be necessary for average-risk individuals, but the cost-benefit balance remains uncertain.
Article
Education, Scientific Disciplines
Tony Seet, Mary A. De Vera, Alyssa Howren, Derek Chan, Simon Albon
CURRENTS IN PHARMACY TEACHING AND LEARNING
(2020)
Article
Oncology
Mary A. De Vera, Sharlene Gill, Shady Ashamalla, Dan Schiller, Darren R. Brenner, Clarence Wong, Petra Wildgoose, Mary Jane Esplen, Christopher Lieu, Roslyn Fitzpatrick, Dylan E. O'Sullivan, Filomena Servidio-Italiano
Summary: The symposium discussed the rising rates of early-age-onset colorectal cancer in Canadians under 50, emphasizing the need for specific approaches to risk factor identification, early detection, and treatment compared to older patients.
Article
Oncology
Alyssa Howren, Eric C. Sayre, Vicki Cheng, Niki Oveisi, Helen McTaggart-Cowan, Stuart Peacock, Mary A. De Vera
Summary: Individuals with young-onset colorectal cancer have a higher risk of depression compared to average-age-onset cancer patients, particularly among males.
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)