期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 60, 期 1, 页码 105-107出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2007.07.015
关键词
plasmid-mediated quinolone resistance; qnrA1; AcrAB efflux pump
The qnrA1 gene was cloned into a plasmid vector and transformed into Escherichia coli strains carrying chromosomal mutations in the acrAB drug efflux system. In acrAB-deleted strains, and in strains overexpressing acrAB, viable qnrA conferred higher MIC levels (at least a 32-fold increase) for fluoroquinolones than were observed in the parent strains. (c) 2008 Elsevier Inc. All rights reserved.
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