Immunological biomarkers for the development and progression of type 1 diabetes

Genetics of type 1 diabetes

(2018) Catherine C .Robertson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Are We There Yet? Finding Ways to Work Together on T1D

(2018) Chantal Mathieu   DIABETES CARE

Allele-specific methylation of type 1 diabetes susceptibility genes

(2018) Alida S.D. Kindt et al.   JOURNAL OF AUTOIMMUNITY

Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression

(2018) Chih-Wei Liu et al.   Journal of Proteomics

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

(2018) Niina Lietzén et al.   Scientific Reports

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children

(2018) Ezio Bonifacio et al.   PLOS MEDICINE

Understanding type 1 diabetes through proteomics

(2017) Inne Crèvecoeur et al.   Expert Review of Proteomics

Temporal profiles of plasma proteome during childhood development

(2017) Chih-Wei Liu et al.   Journal of Proteomics

Quantitative Age-specific Variability of Plasma Proteins in Healthy Neonates, Children and Adults

(2017) Stefan Bjelosevic et al.   MOLECULAR & CELLULAR PROTEOMICS

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity

(2017) Jorma Ilonen et al.   PEDIATRIC DIABETES

A divergent population of autoantigen-responsive CD4 + T cells in infants prior to β cell autoimmunity

(2017) Anne-Kristin Heninger et al.   Science Translational Medicine

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

(2017) Mohammad Alhadj Ali et al.   Science Translational Medicine

Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?

(2017) G. Sebastiani et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Islet Autoantibodies

(2016) Vito Lampasona et al.   Current Diabetes Reports

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

(2016) Anne M. Pesenacker et al.   DIABETES

Circulating CXCR5 + PD-1 + ICOS + Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies

(2016) Tyyne Viisanen et al.   DIABETES

Peptide serum markers in islet autoantibody-positive children

(2016) Christine von Toerne et al.   DIABETOLOGIA

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review

(2016) Iria Gomez-Tourino et al.   JOURNAL OF AUTOIMMUNITY

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

(2016) Christian Hundhausen et al.   Science Translational Medicine

The case for an autoimmune aetiology of type 1 diabetes

(2015) S. I. Mannering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

(2015) Jennie H.M. Yang et al.   DIABETES

Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility

(2015) Robert Moulder et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Predicting Type 1 Diabetes Using Biomarkers

(2015) Ezio Bonifacio   DIABETES CARE

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

(2014) T. Orban et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

(2014) H. Kallionpaa et al.   DIABETES

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children

(2013) P. Achenbach et al.   DIABETOLOGIA

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes

(2013) Xinyu Xu et al.   PLoS One

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

(2012) G. Garg et al.   JOURNAL OF IMMUNOLOGY

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES