Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

Long-Term Performance and Stability of Molecular Shotgun Lipidomic Analysis of Human Plasma Samples

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Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages

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Metabolism of inflammation limited by AMPK and pseudo-starvation

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Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

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Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress–Mediated Apoptosis

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(2012) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms for Insulin Resistance: Common Threads and Missing Links

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Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

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Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

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Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase

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Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

(2011) Olivier Bezy et al.   JOURNAL OF CLINICAL INVESTIGATION

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Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

(2011) Julia Monsénégo et al.   JOURNAL OF HEPATOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

(2010) Josep M. Orellana-Gavaldà et al.   HEPATOLOGY

Analysis of diacylglycerol molecular species in cellular lipid extracts by normal-phase LC-electrospray mass spectrometry

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Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis

(2010) Carole Henique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Long-Chain Acyl Coenzyme A Synthetases During Fatty Acid Loading Induces Lipotoxicity in Macrophages

(2009) Viswanathan Saraswathi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

(2008) Liliana Håversen et al.   ATHEROSCLEROSIS

The PKC  -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis

(2008) X. Qi et al.   JOURNAL OF CELL SCIENCE

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

(2008) Susanne Schiffmann et al.   JOURNAL OF LIPID RESEARCH