期刊
DIABETOLOGIA
卷 58, 期 1, 页码 158-164出版社
SPRINGER
DOI: 10.1007/s00125-014-3402-x
关键词
[U-C-13]-palmitate; [F-18]-Fluoro-6-thia-heptadecanoic acid; Indirect calorimetry; NEFA; Obesity; Positron emission tomography; Subcutaneous adipose tissue; Very low calorie diet; Visceral adipose tissue; Weight loss
资金
- Academy of Finland
- University of Turku
- Turku University Hospital and Abo Acadamy.
- HEPADIP EU FP6 program
- Novo Nordisk foundation
- Finnish Cultural Foundation
- South Western Finland Cultural Foundation
- Juho Vainio Foundation
- Turku University Foundation
- Finnish Sports Institute Foundation
- Finnish Sports Research Foundation
Aims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [F-18]-fluoro-6-thia-heptadecanoic acid (F-18-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6 week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U-C-13]palmitate. Sixteen non-obese participants were controls. Results Obese participants had > 100% higher (p < 0.0001) NEFA uptake in the visceral and subcutaneous abdominal AT depots than controls. VLCD decreased AT mass in all regions (12% to 21%), but NEFA uptake was decreased significantly (18%; p < 0.006) only in the femoral AT. Whole body carbohydrate oxidation decreased, while fat oxidation increased. Conclusions/interpretation The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. We found that visceral fat takes up more NEFAs than subcutaneous AT depots, even after weight loss.
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