期刊
DIABETOLOGIA
卷 57, 期 9, 页码 1830-1833出版社
SPRINGER
DOI: 10.1007/s00125-014-3308-7
关键词
BMI; Chinese; Genetic risk score; HOMA-B; Type 2 diabetes
资金
- Ministry of Science and Technology of China (973 Program) [2012CB524900]
- National Natural Science Foundation of China [30930081, 81321062, 81170734, 81200581]
- Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences [2013KIP107]
- SA-SIBS Scholarship Program
Aims/hypothesis Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. Methods In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing alleles of these variants were tested for associations with type 2 diabetes and related glycaemic traits in 1,873 cases of type 2 diabetes and 1,839 controls in Han Chinese individuals. Logistic and linear regression analyses were performed to determine the association with type 2 diabetes risk or related glycaemic traits, respectively, under an additive model with or without adjustment for BMI. Results The GRS was significantly associated with increased BMI (beta [SE] 0.070 [0.016]; p = 1.33 x 10(-5)) in the overall population. Each additional BMI-increasing allele in the GRS increased type 2 diabetes risk by 1.029-fold (95% CI 1.008, 1.050; p = 0.0056) without adjustment for BMI, and the association was slightly attenuated after adjustment for BMI (OR 1.022; 95% CI 1.002, 1.043; p = 0.035). In non-diabetic controls, the GRS was also associated with HOMA of beta cell function (HOMA-B) with adjustment for BMI (beta [SE] -0.876 [0.345]; p = 0.011). Notably, the association of GRS with type 2 diabetes was abolished after adjusting for HOMA-B (OR 1.012; 95% CI 0.986, 1.039; p = 0.380). Conclusions/interpretation Our results suggested that genetic predisposition to obesity leads to increased risk of type 2 diabetes, independent of BMI and partly through impaired beta cell function.
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