Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: has it promised too much?

Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis

(2013) J. J. Winnick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

(2013) Erika Harno et al.   ENDOCRINOLOGY

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

(2013) Tiina Kipari et al.   FASEB JOURNAL

The Postprandial Rise in Plasma Cortisol in Men Is Mediated by Macronutrient-Specific Stimulation of Adrenal and Extra-Adrenal Cortisol Production

(2013) Roland H. Stimson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

(2013) Ana Tiganescu et al.   JOURNAL OF CLINICAL INVESTIGATION

11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE−/− Mice

(2013) Ricardo A. García et al.   PLoS One

Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing

(2013) Jong-Kyung Youm et al.   WOUND REPAIR AND REGENERATION

Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice

(2012) Yue-jing Wang et al.   ACTA PHARMACOLOGICA SINICA

Salicylate Downregulates 11 -HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization

(2012) M. Nixon et al.   DIABETES

Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo

(2012) K. A. Hughes et al.   DIABETES

Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1

(2012) Gareth G. Lavery et al.   ENDOCRINOLOGY

Association of 11β-hydroxysteroid dehydrogenase type I expression and activity with estrogen receptor β in adipose tissue from postmenopausal women

(2012) Kerry J. McInnes et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

(2011) Roland H. Stimson et al.   DIABETES

Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome

(2011) P. U. Feig et al.   DIABETES OBESITY & METABOLISM

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

(2011) Zoi Michailidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension

(2011) Sukrut Shah et al.   Journal of the American Society of Hypertension

Liver Upregulation of Genes Involved in Cortisol Production and Action Is Associated with Metabolic Syndrome in Morbidly Obese Patients

(2011) Esther Torrecilla et al.   OBESITY SURGERY

Effect of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog

(2010) Dale S. Edgerton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11βHSD1-deficient mice post-MI

(2010) Sara J. McSweeney et al.   CARDIOVASCULAR RESEARCH

The 11- -Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

(2010) J. Rosenstock et al.   DIABETES CARE

A Nonlinear Relationship of Generalized and Central Obesity with Diurnal Cortisol Secretion in the Whitehall II Study

(2010) Meena Kumari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Partial Deficiency or Short-Term Inhibition of 11 -Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

(2010) K. Sooy et al.   JOURNAL OF NEUROSCIENCE

Metabolic Syndrome in Cushing’s Syndrome

(2010) Philippe Chanson et al.   NEUROENDOCRINOLOGY

11 -Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

(2009) S. A. Morgan et al.   DIABETES

Lack of regulation of 11β-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism

(2009) Helga A Sigurjonsdottir et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Omental Adipose Tissue Type 1 11β-Hydroxysteroid Dehydrogenase Oxoreductase Activity, Body Fat Distribution, and Metabolic Alterations in Women

(2009) Alain Veilleux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preliminary report: pharmacologic 11β-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet

(2009) Magalie Berthiaume et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Estrogen Reduces 11β-Hydroxysteroid Dehydrogenase Type 1 in Liver and Visceral, but Not Subcutaneous, Adipose Tissue in Rats

(2009) Therése Andersson et al.   Obesity

Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients

(2009) René Baudrand et al.   OBESITY SURGERY

Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Normal Weight Postmenopausal Women

(2009) Therése Andersson et al.   PLoS One

Cortisol Release From Adipose Tissue by 11 -Hydroxysteroid Dehydrogenase Type 1 in Humans

(2008) R. H. Stimson et al.   DIABETES

Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans

(2008) R. Basu et al.   DIABETES

Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11 -Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5 -Reductase Activity

(2008) J. W. Tomlinson et al.   DIABETES

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

(2008) J. Koska et al.   DIABETOLOGIA

Depot-specific Regulation of the Conversion of Cortisone to Cortisol in Human Adipose Tissue

(2008) Mi-Jeong Lee et al.   Obesity