Article
Biochemistry & Molecular Biology
Mark Marsland, Amiee Dowdell, Chen Chen Jiang, James S. Wilmott, Richard A. Scolyer, Xu Dong Zhang, Hubert Hondermarck, Sam Faulkner
Summary: There is increasing evidence suggesting the involvement of nerve growth factor (NGF) and its receptors in cancer growth. In this study, the expression of NGF, proNGF, TrkA, p75(NTR) and sortilin in melanoma was investigated. The results showed downregulation of NGF/ProNGF and TrkA in melanoma, indicating a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bolanle Fatimat Olabiyi, Catherine Fleitas, Bahira Zammou, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espinet
Summary: Recent research has shown that adult neurogenesis is crucial for cognitive functions, particularly in memory enhancement. However, disruptions in adult neurogenesis, as seen in Alzheimer's disease, can impair spatial memory. By targeting pro-NGF signaling, memory deficits in an AD mouse model were restored, indicating a potential therapeutic target for AD involving adult neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Yusuke Takeda, Hiroshi Takahashi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Summary: ROCK plays a critical role in diabetic nephropathy, with its substrate MYPT1 showing increased phosphorylation in affected patients. Analysis of patients with diabetes treated with fasudil revealed a reduction in proteinuria and potential renal protective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ting-Yang Hsieh, Yi Chang, Su-Jane Wang
Summary: This study found that piperine can protect hippocampal neurons against excitotoxicity induced by kainic acid by modulating the nerve growth factor signaling pathway.
Review
Cardiac & Cardiovascular Systems
Ewa Pius-Sadowska, Boguslaw Machalinski
Summary: Cardiac innervation density reflects the levels of nerve growth factor (NGF) produced by the heart, with changes in NGF expression affecting neuronal remodelling in the heart and vasculature. NGF synthesis and release are altered under different pathological conditions, and its effects extend beyond neuronal survival to beneficial actions on cardiomyocytes and modulation of the nervous and cardiovascular systems. Understanding the diverse functions of NGF may be crucial for developing novel therapeutic strategies.
Review
Clinical Neurology
Jie-Dan Mu, Liang-Xiao Ma, Zhou Zhang, Xu Qian, Qin-Yong Zhang, Ling-Hui Ma, Tian-Yi Sun
Summary: Stroke induces neuroplasticity in the central nervous system, which affects stroke outcomes through neurogenesis such as axonal growth and synapse formation. Acupuncture is a feasible and effective neural regulation strategy to improve functional recovery after stroke by modulating neuroplasticity. This study summarizes the research progress on key factors and signaling pathways related to neurogenesis and reviews the role of acupuncture in promoting neurogenesis for functional recovery after stroke. It aims to provide new therapeutic perspectives and strategies for motor function recovery based on neurogenesis after stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Mengwei Li, Limei Zhang, Xinyan Liu, Guoqiang Wang, Jian Lu, Jifeng Guo, Hongjie Wang, Jinpeng Xu, Yi Zhang, Na Li, You Zhou
Summary: This study found that low-intensity exercise training can improve the heart function and structure of spontaneously hypertensive rats by inhibiting the RhoA/ROCK signaling pathway, providing further evidence for this protective effect.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Sonia Covaceuszach, Doriano Lamba
Summary: The aim of this study is to elucidate the impact of a point mutation in the Nerve Growth Factor gene on its interactions with the precursor and mature form, and to unveil the molecular determinants that trigger their different physiological and pathological outcomes.
Review
Genetics & Heredity
Guangzhao Guan, Richard D. D. Cannon, Dawn E. E. Coates, Li Mei
Summary: The mechanical properties of cells play an important role in tissue homeostasis and various cellular processes. These properties are determined by the cytoskeleton, which is a complex and dynamic network of microfilaments, intermediate filaments, and microtubules. The Rho-kinase/ROCK signaling pathway regulates the architecture of this cytoskeletal network, influencing cell behavior.
Article
Neurosciences
Lucia Lisi, Silvia Marinelli, Gabriella Maria Pia Ciotti, Michela Pizzoferrato, Federica Palmerio, Marta Chiavari, Antonino Cattaneo, Pierluigi Navarra
Summary: Previous studies have indicated that microglial cells in the brain could be a potential target for nerve growth factors. The recombinant mutated form of human nerve growth factor (hNGFp) shows similar neurotrophic properties to wild-type NGF but with lower algogenic activity. The study evaluated the expression of NGF receptors in human microglia cell lines and the effects of hNGFp and NGF on L-arginine metabolism, showing that both types of NGF inhibit iNOS expression and NO production, but only NGF stimulates urea production.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Junya Sugimoto, Hiroshi Satoyoshi, Kazue Takahata, Shizuko Muraoka
Summary: Fabry disease is an X-linked metabolic storage disorder caused by lysosomal alpha-galactosidase A deficiency. Research suggests that the nerve growth factor signaling pathway may be a potential cause of Fabry disease-associated pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Graziana Esposito, Bijorn Omar Balzamino, Maria Luisa Rocco, Luigi Aloe, Alessandra Micera
Summary: This study shows that a single UV exposure can lead to the release of pro-inflammatory/fibrogenic factors by conjunctival fibroblasts, and these effects can be countered by adding NGF, which is related to the cell phenotype. Further research will help to better understand the pleiotropic effects of NGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Moyim Mallick, T. R. Yoithap Prabhunath, Sonia Kumari, M. Elizabeth Sobhia
Summary: Ameloblastoma is a benign odontogenic jawbone tumor where the binding of NGF to TrkA promotes cell survival, proliferation, and differentiation. By utilizing in silico analysis and mutation on interacting residues, a hybrid peptide candidate was designed to disrupt the interaction between NGF and TrkA for potential therapeutic strategies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Yukiko Enomoto, Takashi Onuma, Takamitsu Hori, Kumiko Tanabe, Kyohei Ueda, Daisuke Mizutani, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinji Ogura, Hiroki Iida, Toru Iwama, Osamu Kozawa, Haruhiko Tokuda
Summary: In this study, it was found that the combination of ristocetin and CXCL12 at low doses synergistically activates human platelets via Rac and inhibits Rho/Rho-kinase activation. This provides insights into the interplay between Rac and Rho/Rho-kinase in platelet activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ashwin K. Chetty, Byung Hak Ha, Titus J. Boggon
Summary: This review focuses on the signaling pathways mediated by Rho family small GTPases and the specific roles of type II PAKs. The selectivity of Rho GTPases for PAK family members and the molecular basis for substrate recognition and regulation of signaling are discussed. The cross talk between Rho family small GTPases and the involvement of PAKs in diseases are also addressed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Ghadeer A. Albalawi, Maha Z. Albalawi, Kunuz T. Alsubaie, Athari Z. Albalawi, Mohammed A. F. Elewa, Khalid S. Hashem, Mohammed M. H. Al-Gayyar
Summary: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation of the rectal and colon mucosal cells leading to lesions in the mucosa and submucosa. Crocin, a carotenoid compound found in saffron, has various pharmacological effects including antioxidant, anti-inflammatory, and anticancer activities. This study aimed to investigate the therapeutic effects of crocin on UC by affecting the inflammatory and apoptotic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. F. Elewa, Wagdy M. Eldehna, Ahmed M. E. Hamdan, Samraa H. Abd El-kawi, Asmaa M. El-Kalaawy, Taghreed A. Majrashi, Reham F. Barghash, Hatem A. Abdel-Aziz, Khalid S. Hashem, Mohammed M. H. Al-Gayyar
Summary: This study evaluated the antitumor activity of WRH-2412 in rats with hepatocellular carcinoma (HCC) by affecting the TGF-beta/beta-catenin/alpha-SMA pathway. The results showed that WRH-2412 significantly increased the rats' survival rate and decreased serum alpha-fetoprotein levels. It also reduced the expression of TGF-beta, beta-catenin, SMAD4, fascin, and alpha-SMA in the liver, while increasing the expression of E-cadherin.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Talal S. S. Alharbi, Ziyad S. S. Alshammari, Ziyad N. N. Alanzi, Fahad Althobaiti, Mohammed A. F. Elewa, Khalid S. S. Hashem, Mohammed M. H. Al-Gayyar
Summary: This study investigated the therapeutic effects of genistein on ulcerative colitis (UC) in rats. The results showed that genistein improved inflammation and ulceration in UC rats, while also enhancing antioxidant activity and mitochondrial biogenesis, thus reducing cell apoptosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hanan M. M. Hassan, Nouf M. M. Alatawi, Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. T. Bakhsh, Hussam I. I. Kutbi, Noha Ashy, Mohammed M. H. Al-Gayyar
Summary: Genistein has been found to improve experimentally induced gastric ulcer in rats by reducing gastric tissue fibrosis through the Wnt/beta-catenin/TGF-beta/SMAD4 pathway. In addition, it also decreases the expression of Wnt, beta-catenin, TGF-beta, SMAD4, and PKB, thereby promoting the healing of gastric ulcers.
Editorial Material
Pharmacology & Pharmacy
Nehal M. Ramadan, Priscila O. Barbosa, Nada Abo F. El-Magd, Salma M. Eraky, Mohammed M. H. Al-Gayyar
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yousef F. Alatawi, Marwan A. Alhablani, Fahad A. Al-Rashidi, Waleed S. Khubrani, Salman A. Alqaisi, Hanan M. Hassan, Mohammed M. Al-Gayyar
Summary: This study aimed to assess the protective effects of garcinol, a component of Garcinia fruit, against gastric ulcer in rats. The findings showed that garcinol reduced the expression of DNA polymerization markers, cell proliferation markers, and inflammatory markers, indicating its therapeutic benefits in the treatment of gastric ulcer.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Mohammad A. Alghamdi, Talal A. Khalifah, Hisham S. Alhawati, Mazen Ruzayq, Abdullah Alrakaf, Ahmed Khodier, Mohammed M. Al-Gayyar
Summary: This study found that ferulic acid has antitumor activity, reducing the size and weight of Ehrlich solid carcinoma and improving the structure of muscle cells. Additionally, ferulic acid increases the expression of antioxidant proteins Nrf2 and HO-1 by downregulating HIF-1a, and decreases the expression of proliferation markers cMyc and cyclin D1, as well as cellular regulators mTOR and STAT3.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Afnan F. Alshehri, Ahmed E. Khodier, Mohammed M. Al-Gayyar
Summary: This study aimed to explore the potential chemotherapeutic activity of ligustilide against Ehrlich solid carcinoma (ESC). The results showed that ligustilide effectively reduced tumor size and weight, indicating its antineoplastic activity against ESC. Further research revealed that ligustilide inhibits cell proliferation by suppressing Ki67 and mTOR, activates autophagy through beclin 1 activation, and inhibits apoptosis by upregulating BCL2. Additionally, ligustilide reduced the expression of AMPK, preventing its ability to promote tumor cell growth.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Heba Aljohani, Ahmed E. Khodier, Mohammed M. Al-Gayyar
Summary: This study found that luteolin, a flavonoid compound found in dietary sources such as carrots and celery, has antineoplastic activity against Ehrlich solid carcinoma (ESC) by reducing tumor size and weight while improving muscle cell structure. It works by suppressing Wnt, beta-catenin, and SMAD4, resulting in decreased tumor cell proliferation and differentiation. Additionally, luteolin overexpresses E-cadherin, leading to reduced tumor cell invasion and metastasis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Correction
Biochemistry & Molecular Biology
Mohammed A. F. Elewa, Wagdy M. Eldehna, Ahmed M. E. Hamdan, Samraa H. Abd El-kawi, Asmaa M. El-Kalaawy, Taghreed Majrashi, Reham F. Barghash, Hatem A. Abdel-Azizb, Khalid S. Hashem, Mohammed M. Al-Gayyar
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Saad Alshammari, Abdulrazaq S. AlMasoudi, Aeshah H. AlBuhayri, Hind M. AlAtwi, Shemah S. AlHwiti, Hind M. Alaidi, Abdullah M. Alshehri, Nouf A. Alanazi, Ahmed Aljabri, Mohammed M. Al-Gayyar
Summary: This study investigated the impact of COVID-19 on glycemic control, insulin resistance, and pH in elderly patients with type 2 diabetes. The results showed that COVID-19 led to increased blood glucose and HbA1c levels, elevated insulin resistance, and decreased pH in patients. However, after complete remission, the patients' results returned to their pre-COVID-19 levels.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Faith N. Burnett, Maha Coucha, Deanna R. Bolduc, Veronica C. Hermanns, Stan P. Heath, Maryam Abdelghani, Lilia Z. Macias-Moriarity, Mohammed Abdelsaid
Summary: This study found that SARS-CoV-2 exacerbates cerebrovascular oxidative stress and inflammation in diabetes, leading to decreased cerebral blood flow and cognitive dysfunction. The spike protein of SARS-CoV-2 enhances the destructive arm of the RAAS pathway and aggravates TLR signaling, exacerbating inflammation and cellular apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Afnan Alshehri, Aeshah Albuhayri, May Alanazi, Manal A. Althubaiti, Raghad F. Aljehani, Fai I. Alsharif, Taghreed M. Alatawi, Shouq S. Albalawi, Ahmed E. Khodir, Mohammed M. Al-Gayyar
Summary: This study found that echinacoside has antitumor properties, resulting in a significant decrease in tumor size and weight, an increase in the average survival time of rats, and an improvement in muscle structure. Furthermore, echinacoside was shown to ameliorate hypoxia by suppressing HIF-1 alpha, reduce inflammation by decreasing NFKB and TNF-alpha, decrease proliferation by reducing PI3K, and block cyclin D1 and CDK2 to inhibit differentiation.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Alaa Bagalagel, Reem Diri, Ahmed Noor, Deina Almasri, Hussain Bakhsh, Hussam I. Kutbi, Mohammed M. Al-Gayyar
Summary: This study investigates the therapeutic effects of CAY10500, a TNF-alpha inhibitor, on hepatocellular carcinoma (HCC) induced in rats. The results show that CAY10500 can increase survival rate, reduce serum AFP level, decrease liver nodules, and improve hepatocyte structure in HCC. Furthermore, CAY10500 can enhance the expression of Nrf2 and HO-1.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi, Mohammed M. H. Al-Gayyar
Summary: Fucoidan demonstrated curative effects in rats with experimentally induced UC by improving intestinal morphology, enhancing antioxidant activity, reducing PDE4 expression, and increasing AhR, IL-22 and cAMP expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)