期刊
DIABETOLOGIA
卷 53, 期 12, 页码 2538-2545出版社
SPRINGER
DOI: 10.1007/s00125-010-1888-4
关键词
Prediction and prevention of type 2 diabetes; Exercise; Socioeconomic aspects; Mediation
资金
- European Association for the Study of Diabetes
- British Council
- NHMRC [586623, 233200]
- Australian Government Department of Health and Ageing
- Abbott Australasia Pty
- Alphapharm Pty
- AstraZeneca
- Bristol-Myers Squibb
- City Health Centre-Diabetes Service-Canberra
- Department of Health and Community Services, NT
- Department of Health and Human Services, TAS
- Department of Health, NSW
- Department of Health, WA
- Department of Health, SA
- Department of Human Services, VIC
- Diabetes Australia
- Diabetes Australia NT
- Eli Lilly Australia
- estate of the late E. Wilson
- GlaxoSmithKline
- Jack Brockhoff Foundation
- Janssen-Cilag
- Kidney Health Australia
- Marian FH Flack Trust
- Menzies Research Institute
- Merck Sharp Dohme
- Novartis Pharmaceuticals
- Novo Nordisk Pharmaceuticals
- Pfizer Pty
- Pratt Foundation
- Queensland Health
- Roche Diagnostics Australia
- Royal Prince Alfred Hospital, Sydney
- sanofi-aventis
- sanofi-synthelabo
Aims/hypothesis To identify the impact of socioeconomic status on incident impaired glucose metabolism and type 2 diabetes and to investigate the mediating role of health behaviours on this relationship using national, population-based data. Methods The Australian Diabetes Obesity and Lifestyle (AusDiab) Study is a national, population-based, longitudinal study of adults aged 25 years and above. A total sample of 4,405 people provided complete baseline (1999-2000) and 5 year follow-up (2004-2005) data relevant for these analyses. Fasting plasma glucose and 2 h plasma glucose were obtained from an OGTT, and demographic, socioeconomic and behavioural data were collected by interview and questionnaire. Multinomial logistic regression examined the role of socioeconomic position in the development of diabetes and mediation analyses tested the contribution of health behaviours in this relationship. Results Highest level of education was a stronger predictor of incident impaired glucose tolerance and type 2 diabetes (p=0.002), compared with household income (p=0.103), and occupational grade (p=0.202). Education remained a significant independent predictor of diabetes in fully adjusted models. However, the relationship was attenuated by the health behaviours (smoking and physical activity). Mediation analyses indicated that these behaviours were partial mediators (explaining 27%) of the socioeconomic status-diabetes relationship. Conclusion/interpretation Smoking and physical activity partly mediate the relationship between low education and type 2 diabetes. Identification of these modifiable behavioural mediators should facilitate the development of effective health promotion campaigns to target those at high risk of developing type 2 diabetes.
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