Article
Fisheries
Yuting Xie, Danhong Cheng, Linhong Wang, Fan Chen, Haotian Chen, Huan Ma, Yanou Yang, Xiaochen Yuan
Summary: Glucagon-like peptide-1 (GLP-1) is an effective incretin in mammals, and its physiological function has been studied in glucose-intolerant carnivorous fishes. In this study, we synthesized homologous GLP-1 peptide and studied its effects on appetite and glucose regulation in herbivorous grass carp. The results showed that GLP-1 increased plasma glucose by promoting gluconeogenesis and inhibiting glycogen synthesis, while also suppressing appetite. The expression of proglucagon genes, which produce GLP-1, decreased after a meal in grass carp, suggesting a unique way of regulating plasma glucose in herbivorous fish. This study provides new insights into the differences in glucose utilization among fishes with different food habits, based on GLP-1.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jennifer Ngo, Dong Wook Choi, Illana A. Stanley, Linsey Stiles, Anthony J. A. Molina, Pei-Hsuan Chen, Ana Lako, Isabelle Chiao Han Sung, Rishov Goswami, Min-young Kim, Nathanael Miller, Siyouneh Baghdasarian, Doyeon Kim-Vasquez, Anthony E. Jones, Brett Roach, Vincent Gutierrez, Karel Erion, Ajit S. Divakaruni, Marc Liesa, Nika N. Danial, Orian S. Shirihai
Summary: Changes in mitochondrial morphology, specifically fragmentation and elongation, have been found to impact fatty acid oxidation (FAO) rates. Fragmentation increases FAO, while elongation decreases FAO. The induction of fragmentation also mimics specific biological functions related to enhanced FAO in different cell types. The downstream effector of mitochondrial morphology in regulating FAO is identified as carnitine O-palmitoyltransferase 1 (CPT1). Mechanistically, fragmentation reduces malonyl-CoA inhibition of CPT1, while elongation increases CPT1 sensitivity to malonyl-CoA inhibition.
Review
Biochemistry & Molecular Biology
Mariana Fernandez-Caggiano, Philip Eaton
Summary: The mitochondrial pyruvate carrier (MPC) plays a crucial role in determining the fate of pyruvate in cells, with decreased expression contributing to lactate accumulation in the cytosol. Reduced MPC abundance has also been observed in failing hearts, suggesting a potential causal role in heart failure progression.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Haoran Yang, Qingmei Deng, Tun Ni, Yu Liu, Li Lu, Haiming Dai, Hongzhi Wang, Wulin Yang
Summary: The upregulation of the LPL/FABP4/CPT1 molecular axis during NASH phase is specific and inhibiting it can delay tumor growth and significantly reduce the viability of liver cancer stem cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agricultural Engineering
Hui Guo, Jianwei Yu, Bingshuang Lei, Weiwei Ji, Huanhuan Liu, Bo Yin, Junqing Qian
Summary: Flavonoids are natural compounds with various physiological activities and have great application potential in industries. Esterification of naringin with fatty acids improves its performance, making it a potential fat-soluble antioxidant.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Helena Muley, Karmele Valencia, Josefina Casas, Bea Moreno, Luis Botella, Fernando Lecanda, Rut Fado, Nuria Casals
Summary: Breast cancer is the most common malignancy in women worldwide, and chemoresistance is a major obstacle to patient survival. CPT1C expression has been found to be associated with plasma membrane remodelling and drug resistance in breast cancer cells, suggesting its potential as a predictive biomarker for breast cancer chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Katarzyna Marcinkiewicz, Anita Horodnicka-Jozwa, Tomasz Jackowski, Kamila Straczek, Agnieszka Biczysko-Mokosa, Mieczyslaw Walczak, Elzbieta Petriczko
Summary: NAFLD is a common disease in overweight and obese children, with glucose intolerance increasing the risk. ALT and ultrasound can be used to assess the occurrence of NAFLD, and ultrasound is effective in identifying fatty liver features.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bo-Yeong Jin, Hyun-Ju Kim, Mi-Jeong Oh, Na-Hee Ha, Yong Taek Jeong, Sang-Hyun Choi, Jun-Seok Lee, Nam Hoon Kim, Dong-Hoon Kim
Summary: This study investigated the direct effects of metformin on glucose regulation in the brain by intracerebroventricular administration in mice. The results showed that central metformin improves glucose tolerance by delaying gastric emptying, but worsens it by increasing hepatic glucose production. These findings suggest a dual role of metformin in glucose regulation through the brain-gut and brain-liver axes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Li, Wanwei Zheng, Jie Wu, Jun Zhang, Bin Lv, Wenshuai Li, Jie Liu, Xin Zhang, Tiansheng Huang, Zhongguang Luo
Summary: Overexpression of CPT1C in colorectal cancer is associated with metastasis and poor relapse-free survival, and it promotes cell proliferation and migration.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Gastroenterology & Hepatology
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Vincent Wai-Sun Wong, Marlen Castellanos, Rocio Aller-de la Fuente, Mohammed Eslam, Grace Lai-Hung Wong, Jacob George, Manuel Romero-Gomez, Leon A. Adams
Summary: Type 2 diabetes is associated with increased risk of death and liver-related outcomes in patients with NASH-related cirrhosis, while metformin use is significantly correlated with a reduction in these risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Plant Sciences
Hongtu Hu, Weiwei Li, Yiqun Hao, Zhuan Peng, Zhengping Zou, Wei Liang
Summary: This study elucidated the mechanism through which baicalin (BA) moderates the progression of diabetic kidney disease (DKD). The results showed that BA reduced lipid accumulation and renal fibrosis in DKD mice and downregulated CPT1 alpha expression. Furthermore, in vitro assays confirmed the effects of CPT1 alpha overexpression and BA treatment on mitochondrial respiration, fatty acid oxidation, and renal fibrosis. CPT1 alpha emerges as a promising therapeutic target for DKD intervention.
Article
Cell Biology
Yumeng Miao, Changliu Zhang, Ling Yang, Xi Zeng, Yuxiao Hu, Xinru Xue, Yue Dai, Zhifeng Wei
Summary: This study reveals that the activation of PPAR gamma enhances Treg responses by up-regulating CD36/CPT1-mediated fatty acid oxidation and N-glycan branching of T beta RII/IL-2R alpha, which is beneficial for inflammatory and autoimmune diseases.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Geriatrics & Gerontology
Adam Oesterle, Petra Buzkova, Cara N. Pellegrini, Calvin Hirsch, Russell P. Tracy, David S. Siscovick, Luc Djousse, Ken J. Mukamal, Jorge R. Kizer
Summary: Glucose, both fasting and post-load, is associated with incident heart failure, while non-esterified fatty acids (NEFA) are not. The association is particularly strong for post-load glucose, suggesting potential targets for HF prevention.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Marc Tor, Francesca Vilaro, Roger Ros-Freixedes, Javier alvarez-Rodriguez, Lluis Bosch, Sofia Gol, Ramona N. Pena, Josep Reixach, Joan Estany
Summary: Circulating NEFA can serve as biomarkers for intramuscular fat content and fatty acid composition in pigs, but are influenced by factors like age, fasting duration, and genetic variants. NEFA composition reflects an animal's metabolic status yet has limited value as biomarkers for fat content and composition.
Article
Nutrition & Dietetics
Kamilla Pedersen, David Hojland Ipsen, Josephine Skat-Rordam, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Summary: This study investigated the effects of high-fat diets based on coconut oil or cocoa butter on glucose homeostasis and NASH in guinea pigs. The results showed that a diet high in long-chain fatty acids (LCFA) promoted metabolic imbalance and accelerated NASH-associated hepatic fibrosis. The study highlights the importance of evaluating fatty acid composition when investigating NASH-related endpoints.
Article
Multidisciplinary Sciences
Lixia Zhao, Xuefei Gao, Yuxuan Zheng, Zixin Wang, Gaoping Zhao, Jie Ren, Jia Zhang, Jian Wu, Baojiang Wu, Yanglin Chen, Wei Sun, Yunxia Li, Jie Su, Yulin Ding, Yuan Gao, Moning Liu, Xiaochun Bai, Liangzhong Sun, Guifang Cao, Fuchou Tang, Siqin Bao, Pentao Liu, Xihe Li
Summary: The researchers have successfully established stem cells from porcine and human preimplantation embryos using the EPSC approach, enabling cross-species differentiation. Upon studying bovine EPSCs, they found that these stem cells express high levels of pluripotency genes in feeder-free culture and maintain genetic stability in long-term culture.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Yiwei Zhang, Handi Cao, Jie Chen, Yuanxin Li, Aimin Xu, Yu Wang
Summary: This study demonstrates the importance of adiponectin in the selection and development of T lymphocytes within thymic nurse cell complexes. Adiponectin-expressing regulatory T-cells (Treg) have the potential to improve glucose metabolism in obese mice and inhibit mammary tumor growth, suggesting them as a promising therapeutic agent against obesity-related metabolic and cancer diseases.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Ranyao Yang, Aimin Xu, Alexei Kharitonenkov
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Chi Ho Lee, Andy Ka Chun Kan, David Tak Wai Lui, Carol Ho Yi Fong, Darren Shing Hei Chan, Michele Mae Ann Yuen, Wing Sun Chow, Yu Cho Woo, Aimin Xu, Karen Siu Ling Lam
Summary: This study found that circulating Adipocyte fatty acid-binding protein (AFABP) levels were associated with incident heart failure (HF) hospitalization in type 2 diabetes. Additionally, the use of sodium glucose co-transporter 2 inhibitors (SGLT2i) was shown to lower the risk of HF in these patients.
Article
Biology
Stephen Meek, Tom Watson, Lel Eory, Gus McFarlane, Felicity J. Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Shih, Tim Regan, Ryan Taylor, Linda Sutherland, Anton Gossner, Cosmin Chintoan-Uta, Sarah Fletcher, Philippa M. Beard, Musa A. Hassan, Finn Grey, Jayne C. Hope, Mark P. Stevens, Monika Nowak-Imialek, Heiner Niemann, Pablo J. Ross, Christine Tait-Burkard, Sarah M. Brown, Lucas Lefevre, Gerard Thomson, Barry W. McColl, Alistair B. Lawrence, Alan L. Archibald, Falko Steinbach, Helen R. Crooke, Xuefei Gao, Pentao Liu, Tom Burdon
Summary: This study investigates the potential of porcine pluripotent stem cells to provide a limitless source of macrophages, demonstrating their molecular and functional characteristics, as well as their susceptibility to infection by pig pathogens. The study also shows the successful application of CRISPR/Cas9 gene editing in these cells, presenting new opportunities for researching host-pathogen interactions in pigs.
Article
Endocrinology & Metabolism
Wei Sun, Tao Nie, Kuai Li, Wenjie Wu, Qiaoyun Long, Tianshi Feng, Liufeng Mao, Yuan Gao, Qing Liu, Xuefei Gao, Dewei Ye, Kaixuan Yan, Ping Gu, Yong Xu, Xuemei Zhao, Kang Chen, Kerry Martin Loomes, Shaoqiang Lin, Donghai Wu, Xiaoyan Hui
Summary: This study reveals that deficiency of hepatic CPT1A protects against high-fat diet-induced liver damage and enhances adipose browning. Activation of the peroxisome proliferator-activated receptor alpha-fibroblast growth factor 21 (FGF21) axis in the liver contributes to the improved metabolic state.
Article
Multidisciplinary Sciences
Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng
Summary: The study reveals that the early endosomal APPL1-Rab5 axis helps remove damaged mitochondria and restricts inflammasome response in macrophages, mitigating inflammatory diseases.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Howell Leung, Xiaoxue Long, Yueqiong Ni, Lingling Qian, Emmanouil Nychas, Sara Leal Siliceo, Dennis Pohl, Kati Hanhineva, Yan Liu, Aimin Xu, Henrik B. Nielsen, Eugeni Belda, Karine Clement, Rohit Loomba, Huating Li, Weiping Jia, Gianni Panagiotou
Summary: A growing body of evidence suggests that the gut microbiota plays a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study found that machine learning models integrating microbial signatures were able to accurately classify individuals based on their NAFLD status and liver fat accumulation, outperforming other clinical models. These findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Candela Diaz-Canestro, Brandon Pentz, Arshia Sehgal, Ranyao Yang, Aimin Xu, David Montero
Summary: Recent evidence suggests a link between lean body mass (LBM) and cardiovascular capacity in women. This study found that leg and arm LBM were positively associated with cardiac dimensions, ventricular relaxation, and vascular resistance in women, but not in men.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Wenchong Zou, Mingqiang Lai, Yuanjun Jiang, Linlin Mao, Wu Zhou, Sheng Zhang, Pinglin Lai, Bin Guo, Tiantian Wei, Chengtao Nie, Lei Zheng, Jiahuan Zhang, Xuefei Gao, Xiaoyang Zhao, Laixin Xia, Zhipeng Zou, Anling Liu, Shiming Liu, Zhong-Kai Cui, Xiaochun Bai
Summary: The accumulation of obsolete biomolecules can accelerate cell senescence and organism aging. The ubiquitin-proteasome system and the autophagy-lysosome system play important roles in dealing with cellular wastes. However, how multicellular organisms orchestrate the processing of obsolete molecules and delay aging remains unclear.
Article
Medicine, General & Internal
Juanying Zhen, Shuyun Liu, Ryan Yan Lam Kam, Guoru Zhao, Hao Peng, Jianguo Liang, Aimin Xu, Chao Li, Lijie Ren, Jun Wu, Bernard Man Yung Cheung
Summary: We aimed to investigate the relationship of B2M, cystatin C, and LCN-2 with stroke risk in a general Chinese population. Elevated levels of serum B2M, cystatin C, and LCN-2 were significantly associated with stroke risk. These biomarkers may serve as useful tools for clinicians to assess stroke risk.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Yu-Cho Woo, Wing-Sun Chow, Ian Yat-Hin Wong, Aimin Xu, Karen Siu-Ling Lam
Summary: This study evaluated the associations of three diabetes-related biomarkers (AFABP, FGF21, and PEDF) with the development of sight-threatening diabetic retinopathy (STDR). The results showed that serum AFABP level was independently associated with incident STDR and its addition to a clinical model improved the prediction of STDR among participants without baseline retinopathy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Transplantation
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Wing-Sun Chow, Aimin Xu, Karen Siu-Ling Lam
Summary: This study aimed to investigate the association between serum TSP2 level and kidney function decline in patients with type 2 diabetes. The results showed that serum TSP2 level was independently associated with incident eGFR decline and could predict a rapidly declining trajectory. This finding is of great importance for the renal health management of patients with diabetes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)
Article
Primary Health Care
Juanying Zhen, Shuyun Liu, Guoru Zhao, Hao Peng, Aimin Xu, Chao Li, Jun Wu, Bernard Man Yung Cheung
Summary: This study investigates the relationship between lifestyle and hypertension in a Chinese population and finds that a healthy lifestyle score is inversely related to the risk of hypertension. This highlights the importance of addressing lifestyle to reduce the risk of hypertension.