Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Alessia Riccio, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study found that deteriorated glucose homeostasis in women is associated with greater fat accumulation and worsening insulin sensitivity compared to men.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Jacob D. Kohlenberg, Marcello C. Laurenti, Aoife M. Egan, Daniel Schembri Wismayer, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
Summary: People with isolated impaired fasting glucose (IFG) have normal beta cell function. It is found that alpha cell dysfunction in IFG contributes to the pathogenesis of the disease independently of defects in insulin secretion.
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Masanobu Hibi, Yuji Matsui, Sachiko Niwa, Sachiko Oishi, Aya Yanagimoto, Takahiro Ono, Tohru Yamaguchi
Summary: Corosolic acid has been found to improve glucose tolerance in both healthy individuals and prediabetic subjects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Xin Zhang, Yankun Yue, Shaobo Liu, Xiangfeng Cong, Wenjuan Wang, Jianhong Li
Summary: This study investigates the relationship between BMI and the risk of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in Chinese adults. The results show that obesity is an important risk factor for IGT and IFG in China, and the risk of IGT increases during the overweight stage.
Article
Endocrinology & Metabolism
Takashi Nakagata, Yoshifumi Tamura, Hideyoshi Kaga, Motonori Sato, Nozomu Yamasaki, Yuki Someya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study found that ingestion of KM can reduce the AUC of glucose during a 75-g OGTT in Japanese individuals with impaired glucose tolerance, and this mechanism may involve elevated levels of circulating early-phase insulin.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Neurosciences
Sini Toppala, Laura L. Ekblad, Matti Viitanen, Juha O. Rinne, Antti Jula
Summary: This study examined whether the early insulin response to oral glucose load predicts cognitive performance after 10 years in men and women aged 45-74 years. The results showed that a lower early insulin response was associated with poorer performance and greater decline in episodic memory test. This suggests that decreased early insulin secretion predicts episodic memory decline in middle-aged to elderly individuals.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Endocrinology & Metabolism
Domenico Trico, Alessandro Mengozzi, Simona Baldi, Roberto Bizzotto, Oladapo Olaniru, Klaudia Toczyska, Guo Cai Huang, Marta Seghieri, Silvia Frascerra, Stephanie A. Amiel, Shanta Persaud, Peter Jones, Andrea Mari, Andrea Natali
Summary: The study found that mild acute hypertriglyceridemia impairs oral glucose tolerance and whole-body insulin sensitivity, resulting in increased post-glucose hyperinsulinemia due to reduced insulin clearance and enhanced hyperglycemia-induced total insulin secretion. Additionally, high-physiologic triglyceride levels can increase insulin secretion.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Camila Pires Mendes, Barbara Graziela Postal, Marisa Jadna Silva Frederico, Rui Goncalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patricia Devantier Neuenfeldt, Ricardo Jose Nunes, Fatima Regina Mena Barreto Silva
Summary: A new library of hybrid compounds was developed to optimize the pharmacological activities of two drugs for the treatment of type 2 diabetes, potentially minimizing adverse effects. Among the screened compounds, PTEBS was identified to effectively regulate glucose and lipid homeostasis.
BIOORGANIC CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Aline Isabel Rodrigues Galvao, Alline Maria R. Beleigoli, Pedro Guatimosim Vidigal, Bruce Bartholow Duncan, Maria Ines Schmidt, Sarah L. Appleton, Sandhi Maria Barreto, Maria de Fatima Haueisen Sander Diniz
Summary: The study found a significant association between higher serum uric acid levels and glycemic status, including impaired fasting glucose, impaired glucose tolerance, and diabetes, as well as insulin resistance, mainly among women, in a large Latin American population.
CADERNOS DE SAUDE PUBLICA
(2021)
Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2015)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2015)
Article
Geriatrics & Gerontology
Sara E. Espinoza, Chen-pin Wang, Devjit Tripathy, Stephen C. Clement, Dawn C. Schwenke, Mary Ann Banerji, George A. Bray, Thomas A. Buchanan, Robert R. Henry, Abbas E. Kitabchi, Sunder Mudaliar, Frankie B. Stentz, Peter D. Reaven, Ralph A. DeFronzo, Nicolas Musi
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2016)
Article
Endocrinology & Metabolism
Devjit Tripathy, Dawn C. Schwenke, MaryAnn Banerji, George A. Bray, Thomas A. Buchanan, Stephen C. Clement, Robert R. Henry, Abbas E. Kitabchi, Sunder Mudaliar, Robert E. Ratner, Frankie B. Stentz, Nicolas Musi, Peter D. Reaven, Ralph A. DeFronzo
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Biochemistry & Molecular Biology
Juraj Koska, Hussein Yassine, Olgica Trenchevska, Shripad Sinari, Dawn C. Schwenke, Frances T. Yen, Dean Billheimer, Randall W. Nelson, Dobrin Nedelkov, Peter D. Reaven
JOURNAL OF LIPID RESEARCH
(2016)
Article
Cardiac & Cardiovascular Systems
Sandesh Dev, Trisha K. Hoffman, Dio Kavalieratos, Paul Heidenreich, Wen-Chih Wu, Dawn C. Schwenke, Sarah J. Tracy
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2018)
Article
Endocrinology & Metabolism
Jin J. Zhou, Dawn C. Schwenke, Gideon Bahn, Peter Reaven
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Dawn C. Schwenke
CURRENT OPINION IN LIPIDOLOGY
(2021)
Article
Health Care Sciences & Services
Sandesh Dev, Janet Fawcett, Shahjehan Ahmad, Wen-Chih Wu, Dawn Schwenke
Summary: A new multidisciplinary approach for early postdischarge hospital follow-up in heart failure patients was successful in increasing referral and completion rates for cardiology appointments within 7 days of discharge and reducing the risk of all-cause emergency department visits, hospitalizations, or death within 30 days.
AMERICAN JOURNAL OF MANAGED CARE
(2021)
Article
Endocrinology & Metabolism
Aramesh Saremi, Scott Howell, Dawn C. Schwenke, Gideon Bahn, Paul J. Beisswenger, Peter D. Reaven