Article
Cardiac & Cardiovascular Systems
Vivek Jani, Filip Konecny, Aaron Shelby, Aparna Kulkarni, James Hammel, Andreas Schuster, John Lof, David Danford, Shelby Kutty
Summary: This study investigated the effects of pulmonary stenosis and pulmonary insufficiency on ventricular interactions using a porcine model. The results showed that pulmonary stenosis was associated with preserved LV systolic function and evidence of some LV diastolic dysfunction, while pulmonary insufficiency was associated with LV systolic dysfunction and noncompliance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Endocrinology & Metabolism
Marijana Tadic, Jelena Suzic-Lazic, Vladan Vukomanovic, Cesare Cuspidi, Sanja Ilic, Vera Celic
Summary: This study evaluated cardiorespiratory fitness in type 2 diabetic patients with different levels of left ventricular diastolic dysfunction (LVDD). The findings showed that LVDD significantly impacted functional capacity in diabetic patients, with parameters such as left ventricular hypertrophy and diastolic function being affected.
ACTA DIABETOLOGICA
(2021)
Article
Multidisciplinary Sciences
Zheina Cherneva, Dinko Valev, Vania Youroukova, Radostina Cherneva
Summary: This study aimed to evaluate the predictive value of inflammatory, oxidative stress, cardio-pulmonary, and echocardiographic parameters at rest for the diagnosis of stress LVDD in non-severe COPD patients. Results showed a high prevalence of masked HFpEF in COPD patients, with parameters like RV E/A >0.75 being the best independent predictors for stress LVDD.
Article
Cardiac & Cardiovascular Systems
Lisa Van Ryckeghem, Charly Keytsman, Kenneth Verboven, Elvire Verbaanderd, Ines Frederix, Elise Bakelants, Thibault Petit, Siddharth Jogani, Sarah Stroobants, Paul Dendale, Virginie Bito, Jan Verwerft, Dominique Hansen
Summary: In Type 2 diabetes mellitus patients, impaired exercise capacity is associated with impaired response in oxygen extraction and myocardial deformation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Franziska Sciuk, Theresa Vilsmaier, Marie Kramer, Magdalena Langer, Brenda Kolbinger, Pengzhu Li, Andre Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
Summary: Children conceived through assisted reproductive technologies (ART) may have impaired left ventricular (LV) diastolic function. This study found that young ART subjects had lower LV diastolic function compared to their spontaneously conceived peers. However, when adjusted for age, birth weight percentile, and gestational age, there were no significant differences between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Jarkko S. Heiskanen, Saku Ruohonen, Suvi P. Rovio, Katja Pahkala, Ville Kyto, Mika Kahonen, Terho Lehtimaki, Jorma S. A. Viikari, Markus Juonala, Tomi Laitinen, Paivi Tossavainen, Eero Jokinen, Nina Hutri-Kahonen, Olli T. Raitakari
Summary: The study found that elevated systolic blood pressure and increased adiposity in childhood were associated with worse adulthood left ventricular diastolic function, while higher physical activity level in childhood was associated with better adulthood left ventricular diastolic function. However, the associations of childhood adiposity and physical activity with adulthood left ventricular diastolic function were weakened when adjusting for adulthood systolic blood pressure, adiposity, and physical activity. The association between childhood systolic blood pressure and adult left ventricular diastolic function became nonsignificant when adjusting for other factors in adulthood.
Article
Medicine, General & Internal
Wei-Ming Huang, Hao-Chih Chang, Ching-Wei Lee, Chi-Jung Huang, Wen-Chung Yu, Hao-Min Cheng, Chao-Yu Guo, Chern-En Chiang, Chen-Huan Chen, Shih-Hsien Sung
Summary: This study aimed to investigate the association between spirometric indices, cardiac functions, and clinical outcomes. The results showed that patients with a restrictive or mixed spirometry pattern had worse cardiac function and prognosis. Additionally, there was an inverse nonlinear relationship between FVC and DDi, suggesting that the declined FVC may mediate 43% of the prognostic hazard of left ventricular diastolic dysfunction.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Mei-Zhen Wu, Yan Chen, Yu-Juan Yu, Zhe Zhen, Ying-Xian Liu, Yuan Zou, Lai-Ming Ho, Qing-Shan Lin, Ming-Yen Ng, Karen Siu-Ling Lam, Hung-Fat Tse, Kai-Hang Yiu
Summary: This study found that in patients with type 2 diabetes, women were more likely to have left ventricular hypertrophy and diastolic dysfunction compared to men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with type 2 diabetes, while this association was neutral in men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Dimitrios Rovithis, Maria Anifanti, Nikolaos Koutlianos, Andriana Teloudi, Evangelia Kouidi, Asterios Deligiannis
Summary: This study suggests that healthy middle-aged men with high levels of physical activity may have improved diastolic left ventricular (LV) function compared to men with low levels of physical activity, as observed by their different responses to isometric handgrip exercise.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Angel Lopez-Candales, Talal Asif, Khalid Sawalha, Nicholas B. Norgard
Summary: In the past two decades, the understanding of heart failure with preserved ejection fraction (HFpEF) has evolved, recognizing it as a complex clinical entity with various abnormalities beyond left ventricular diastolic dysfunction. HFpEF is associated with multiorgan dysfunction, with hypertension and obesity playing a major role. Although progress has been made in understanding the causes and effects of HFpEF, there is still much to learn. This review aims to synthesize the recent attributes, mechanisms, diagnostic tools, and therapeutic alternatives for evaluating and treating patients with HFpEF.
CARDIOVASCULAR THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Reiter, Ursula Reiter, Corina Kraeuter, Ewald Kolesnik, Daniel Scherr, Albrecht Schmidt, Michael Fuchsjaeger, Gert Reiter
Summary: The study aimed to investigate the association between the magnetic resonance 4D flow imaging-derived left atrial acceleration factor alpha and the severity of left ventricular diastolic dysfunction. It was found that alpha could accurately differentiate advanced diastolic dysfunction from non-advanced dysfunction, as well as distinguish between different grades of diastolic dysfunction. Additionally, as a single continuous parameter, alpha has the potential to simplify the diagnosis of advanced diastolic dysfunction.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Michele Arcopinto, Roberta D'Assante, Renata Simona Auriemma, Rosa Pirchio, Rosario Pivonello, Eduardo Bossone, Annamaria Colao, Antonio Cittadini
Summary: This study examines the effects of chronic hyperprolactinemia on cardiac structure and function in humans. It finds that hyperprolactinemic patients show a slight impairment of diastolic filling and a worse exercise capacity, particularly in a subgroup of females. However, there are no significant abnormalities in left ventricular structure and systolic function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
X. Chen, X. Shui, H. Xu, J. Peng, H. Deng, J. Zhong, C. Wang, J. Wu, J. Yan, B. Yao, Z. Xiong, W. Xu, X. Yang
Summary: Deteriorating sudomotor function is associated with reduced diastolic function indicators, and ESC can be used as a biomarker for detecting LV diastolic impairment.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Melanie Bezard, Fabien Le Bras, Jean-Francois Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Summary: All LVDF patterns can be observed in CA, and one quarter of CA patients have a better prognosis with grade I LVDF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Paolo Formenti, Silvia Coppola, Laura Massironi, Giacomo Annibali, Francesco Mazza, Lisa Gilardi, Tommaso Pozzi, Davide Chiumello
Summary: This study aimed to evaluate the presence of diastolic dysfunction in mechanically ventilated ARDS patients and found those with diastolic dysfunction had higher lung edema and worse outcomes, but the impact on oxygenation and respiratory mechanics was not significant.
JOURNAL OF CLINICAL MEDICINE
(2022)