Article
Endocrinology & Metabolism
Karina Rodrigues-dos-Santos, Gitanjali Roy, Derk D. Binns, Magdalena G. Grzemska, Luiz F. Barella, Fiona Armoo, Melissa K. McCoy, Andy Huynh, Jonathan Z. Yang, Bruce A. Posner, Melanie H. Cobb, Michael A. Kalwat
Summary: The small molecule SW016789 has time-dependent effects on endoplasmic reticulum (ER) stress and function in pancreatic islet beta cells. Acute treatment enhances insulin secretion, while chronic exposure transiently induces ER stress and inhibits secretory function in a reversible manner. SW016789 acts upstream of voltage-dependent calcium channels and potentiates nutrient-induced calcium influx.
Article
Pharmacology & Pharmacy
Carine Marmentini, Dimitrius Santiago P. S. F. Guimaraes, Tanes de Lima, Francisco Breno S. Teofilo, Natalia S. da Silva, Gabriela M. Soares, Antonio C. Boschero, Mirian A. Kurauti
Summary: The study demonstrates that rosiglitazone can improve the viability of INS-1E cells exposed to hIAPP, independent of insulin-degrading enzyme (IDE) modulation. Rosiglitazone inhibited hIAPP fibrillation and reduced hIAPP-induced expression of CHOP, ATF4, and p-eIF2a, suggesting that TZDs treatment may be a promising approach to preserve β-cell mass and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sara de Pablo, Julia Rodriguez-Comas, Daniela Diaz-Catalan, Gema Alcarraz-Vizan, Carlos Castano, Juan Moreno-Vedia, Joel Montane, Marcelina Parrizas, Joan-Marc Servitja, Anna Novials
Summary: The study shows that the chemical chaperone PBA significantly reduces hyperglycemia and amyloid deposits in obese and diabetic mice, highlighting the potential for T2D treatment.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yan-Nan Chi, Rui-Juan Ye, Jia-Mei Yang, Dong-Mei Hai, Ning Liu, Jia-Wei Ren, Juan Du, Xiao-Bing Lan, Jian-Qiang Yu, Lin Ma
Summary: The study found that geniposide can improve spermatogenic dysfunction induced by cyclophosphamide in mice, increase sperm quantity and activity, alleviate sperm DNA damage and endoplasmic reticulum stress, inhibit cell apoptosis, and protect the testis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xue Li, Mingming Zhen, Chen Zhou, Meilan Yu, Lei Liu, Chunying Shu, Chunru Wang
Summary: This study investigates the use of hydroxylated [70] fullerene nanoparticles (HFNPs) as antioxidants to reverse insulin resistance in diabetes. The study shows that HFNPs can alleviate insulin resistance by regulating oxidative stress and endoplasmic reticulum stress, resulting in improved glucose uptake and reduced blood glucose levels. Furthermore, HFNPs inhibit the activation of phosphorylated c-Jun N-terminal kinase (JNK), reactivating the insulin receptor substrate (IRS) signaling pathway and inhibiting gluconeogenesis. Importantly, HFNPs exhibit no severe toxicity to main tissues. This research contributes to the understanding of the role of antioxidants in regulating insulin resistance and provides new perspectives for the treatment of insulin resistance-related diseases.
Article
Biochemistry & Molecular Biology
Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang
Summary: JAT has vasoprotective effects in diabetes and obesity by enhancing the Akt/eNOS pathway and NO bioavailability, as well as suppressing ER stress and oxidative stress to improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Matshediso Zachariah, Hatem Maamoun, Larissa Milano, Margaret P. Rayman, Lisiane B. Meira, Abdelali Agouni
Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Nasrin Abolhasanpour, Samin Alihosseini, Sevda Golipourkhalili, Reza Badalzadeh, Javad Mahmoudi, Leila Hosseini
Summary: Ischemic stroke leads to a cascade of cellular mechanisms in the brain, with melatonin showing beneficial effects in reducing oxidative stress, inflammation, and apoptosis. Studies suggest that melatonin therapy after stroke can improve mitochondrial dysfunction and alleviate ER stress and inflammation. The impact of melatonin on mitochondrial and ER function, as well as the crosstalk between the two organelles, is discussed as a therapeutic target for stroke.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Matthew W. Pitts, Lucia A. Seale, Jessica L. Nicholson, Pamela Toh, Jun Kyoung Kim, Marla J. Berry, Daniel J. Torres
Summary: The use of glucocorticoid medications can cause metabolic side effects such as overeating, weight gain, and insulin resistance. The hypothalamus, a regulator of feeding behavior and energy expenditure, is responsive to glucocorticoids and may play a role in metabolic defects. Selenium has been found to counter the effects of glucocorticoids and is important for hypothalamic function. This study aimed to investigate if selenium could protect hypothalamic cells from dysfunction caused by glucocorticoid exposure.
Article
Endocrinology & Metabolism
George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Sos Skovso, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout
Summary: This study aims to investigate the crucial role of pancreatic beta cells in maintaining glucose homeostasis and the impact of sex differences on this process. By comparing the gene expression and function of beta cells in males and females, we found that female patients have more reliable insulin secretion and higher resilience to endoplasmic reticulum stress.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Yan Zhou, Chunxiu Zhou, Xutao Zhang, Chi Teng Vong, Yitao Wang, Wai San Cheang
Summary: The study showed that coptisine can improve vascular function in diabetic patients by suppressing ER stress and oxidative stress, enhancing endothelium-dependent relaxation, indicating the therapeutic potential of coptisine for treating diabetic vasculopathy.
Article
Multidisciplinary Sciences
Ruiying Hu, Xiaodong Zhu, Mingyang Yuan, Kung-Hsien Ho, Irina Kaverina, Guoqiang Gu
Summary: For sustainable function, each pancreatic islet beta cell maintains thousands of insulin secretory granules (SGs). Glucose stimulation induces the secretion of a small portion of these SGs and simultaneously boosts SG biosynthesis to sustain this stock. Young insulin SGs are more likely secreted during glucose-stimulated insulin secretion (GSIS), while older SGs tend to lose releasability and be degraded. The roles of microtubule (MT) and G alpha o-signaling in regulating the preferential secretion of young versus old SGs are examined in this study.
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Endocrinology & Metabolism
B. Hayward, J. C. Molero, K. Windmill, A. Sanigorski, J. Weir, N. L. McRae, K. Aston-Mourney, B. Osborne, B. Liao, K. R. Walder, P. J. Meikle, N. Konstantopoulos, C. Schmitz-Peiffer
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2016)
Review
Endocrinology & Metabolism
Smithamol Sithara, Tamsyn M. Crowley, Ken Walder, Kathryn Aston-Mourney
JOURNAL OF ENDOCRINOLOGY
(2017)
Meeting Abstract
Endocrinology & Metabolism
Smithamol Sithara, Bhavisha Patel, Megan K. Ellis, Tamsyn Crowley, Ken Walder, Kathryn Aston-Mourney
Article
Endocrinology & Metabolism
Juliane K. Czeczor, Amanda J. Genders, Kathryn Aston-Mourney, Timothy Connor, Liam G. Hall, Kyoko Hasebe, Megan Ellis, Kirstie A. De Jong, Darren C. Henstridge, Peter J. Meikle, Mark A. Febbraio, Ken Walder, Sean L. McGee
JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Kathryn Aston-Mourney, Shoba L. Subramanian, Sakeneh Zraika, Thanya Samarasekera, Daniel T. Meier, Lynn C. Goldstein, Rebecca L. Hull
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2013)
Article
Public, Environmental & Occupational Health
Mark M. Smits, Pier Woudstra, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Mirjam Faulenbach, Darcy B. Carr, Kathryn Aston-Mourney, Alan Chait, Robert H. Knopp, James B. Meigs, Edward J. Boyko, Steven E. Kahn
ANNALS OF EPIDEMIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Kathryn Aston-Mourney, Sakeneh Zraika, Jayalakshmi Udayasankar, Shoba L. Subramanian, Pattie S. Green, Steven E. Kahn, Rebecca L. Hull
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Immunology
J. Udayasankar, S. Zraika, K. Aston-Mourney, S. L. Subramanian, B. M. Brooks-Worrell, G. J. Taborsky, R. L. Hull
TRANSPLANTATION PROCEEDINGS
(2013)
Article
Endocrinology & Metabolism
Jacob McCann, Megan Ellis, Sean L. McGee, Kathryn Aston-Mourney
Review
Endocrinology & Metabolism
Ramasamy Aarthy, Kathryn Aston-Mourney, Antonina Mikocka-Walus, Venkatesan Radha, Anandakumar Amutha, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Viswanathan Mohan
Summary: MODY has 14 subtypes, with the common ones well understood and the rare ones lacking in knowledge. The advent of NGS technology has led to more progress in the study of rare subtypes.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Peter M. Meggyesy, Shashank Masaldan, Sharnel A. S. Clatworthy, Irene Volitakis, Daniel J. Eyckens, Kathryn Aston-Mourney, Michael A. Cater
Article
Endocrinology & Metabolism
Georgia Wyett, Yann Gibert, Megan Ellis, Hozana A. Castillo, Jan Kaslin, Kathryn Aston-Mourney
Article
Endocrinology & Metabolism
Vidhi Gaur, Timothy Connor, Kylie Venardos, Darren C. Henstridge, Sheree D. Martin, Courtney Swinton, Shona Morrison, Kathryn Aston-Mourney, Stefan M. Gehrig, Roelof van Ewijk, Gordon S. Lynch, Mark A. Febbraio, Gregory R. Steinberg, Mark Hargreaves, Ken R. Walder, Sean L. McGee
DIABETES OBESITY & METABOLISM
(2017)
Meeting Abstract
Endocrinology & Metabolism
Mark M. Smits, Pier Woudstra, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Mirjam Faulenbach, Darcy B. Carr, Kathryn Aston-Mourney, Alan Chait, Robert H. Knopp, James B. Meigs, Edward J. Boyko, Steven E. Kahn
Meeting Abstract
Endocrinology & Metabolism
Kathryn Aston-Mourney, Sakeneh Zraika, Tanya Samarasekera, Daniel T. Meier, Rebecca L. Hull