Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Tyler L. Coye, Mehmet A. Suludere, Gu Eon Kang, P. Andrew Crisologo, Matthew Malone, Lee C. Rogers, Lawrence A. Lavery
Summary: The objective of this study was to evaluate the effectiveness of various biomarkers, including C-reactive protein, erythrocyte sedimentation rate, and albumin, and their ratios in differentiating bone and soft tissue infection in individuals with diabetes. The results showed that the ESR/albumin and CRP/albumin ratios provided comparable diagnostic accuracy to using ESR and CRP alone.
WOUND REPAIR AND REGENERATION
(2023)
Review
Endocrinology & Metabolism
Brian M. Schmidt, John Erb-Downward, Piyush Ranjan, Robert Dickson
Summary: Research indicates that diabetic foot ulcers are a growing problem with current healing rates below 50%. Metagenomic sequencing technology offers a comprehensive understanding of the polymicrobial constituency of DFU, but standardized research methods based on real-world clinical practices are needed to bridge the knowledge gap.
CURRENT DIABETES REPORTS
(2021)
Article
Immunology
Shiwei Zhou, Brian M. Schmidt, Oryan Henig, Keith S. Kaye
Summary: Patients with diabetic foot osteomyelitis who deferred amputation and opted for medical therapy had a higher risk of mortality during the follow-up period compared to those who underwent amputation.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Laura Soldevila-Boixader, Alberto Perez Fernandez, Javier Munoz Laguna, Ilker Uckay
Summary: With the increasing global burden of diabetes, diabetic foot infections (DFI) and diabetic foot osteomyelitis (DFO) present major challenges. There is uncertainty regarding the optimal medical treatment for these conditions, specifically whether local antibiotics should be used alone or in combination with systemic antibiotics. A narrative review was performed to summarize relevant studies on non-prophylactic local antibiotics for DFI and DFO treatment. The findings suggest limited evidence for the use of local antibiotic delivery systems in standard DFO treatment, and highlight the potential benefits of adding local agents to conventional systemic antibiotics for infected diabetic foot ulcers.
Article
Infectious Diseases
Parichehr Hadi, Sanjiv Rampal, Vasantha Kumari Neela, Manraj Singh Cheema, Sandeep Singh Sarawan Singh, Eng Kee Tan, Ajantha Sinniah
Summary: Diabetes mellitus is a global pandemic, particularly in Southeast Asia, and diabetic foot infection is a common and serious complication of this disease. However, there is a lack of locally published data on the types of microorganisms and antibiotics prescribed. This study aims to address this gap by examining the local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. The findings of this study could greatly contribute to the development of empirical therapy guidelines for treating diabetic foot infections in the future.
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Ka-Huen Yip, Yuk-Chiu Yip, Wai-King Tsui
Summary: This study explored the thoughts and experiences of patients with diabetic foot ulcers in Hong Kong regarding lower-limb amputation. It found that lower-limb amputation is considered a forbidden topic, making it culturally difficult for Chinese patients to discuss the matter with healthcare authorities and family members. Healthcare workers should be aware of how they communicate regarding lower-limb amputation.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Endocrinology & Metabolism
Hakan Dogruel, Mustafa Aydemir, Mustafa Kemal Balci
Summary: Diabetic foot ulcers are one of the most challenging complications of diabetes, with about one-third of diabetes patients affected. The disease has a high recurrence rate, highlighting the importance of prevention strategies. A multidisciplinary approach is necessary for treatment, including preventive measures based on patient risk and appropriate treatment interventions.
WORLD JOURNAL OF DIABETES
(2022)
Review
Orthopedics
Kaissar Yammine, Anthony El Alam, Bilal Alqaysi, Chahine Assi
Summary: This systematic review examines the effectiveness of internal pedal amputation (IPA) in treating selected cases of diabetic foot osteomyelitis. The results show that IPA is a viable surgical option with high success rate and few serious complications.
FOOT AND ANKLE SURGERY
(2022)
Article
Biology
Florin Bobirca, Catalin Gabriel Smarandache, Anca Bobirca, Cristina Alexandru, Dan Dumitrescu, Anca Pantea Stoian, Cristina Bica, Lacramioara Aurelia Brinduse, Anca Musetescu, Daniela-Elena Gheoca-Mutu, Sebastian Isac, Ioan Ancuta
Summary: This study describes the appropriate surgical intervention for complicated neuropathic diabetic foot and identifies risk factors associated with amputation and surgical outcomes.
Article
Infectious Diseases
Meryl Cinzia Tila Tamara Gramberg, Jarne Marijn Van Hattem, Jacob Albert Dijkstra, Emma Dros, Max Nieuwdorp, Louise Willy Elizabeth Sabelis, Edgar Josephus Gerardus Peters
Summary: Prior antibiotic use does not affect culture yield or antibiotic resistance in people with diabetes and osteomyelitis of the foot, regardless of biopsy type.
Article
Immunology
David H. Truong, Roger Bedimo, Matthew Malone, Dane K. Wukich, Orhan K. Oz, Amanda L. Killeen, Lawrence A. Lavery
Summary: The clinical outcomes of medical and surgical management for diabetic foot osteomyelitis (DFO) were evaluated. The average success rate was 68.2% for medical treatment and 85.7% for surgical and medical treatment. Further prospective studies are required to determine whether medical management can be successful without surgical intervention.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Endocrinology & Metabolism
Gerry Rayman, Prashanth Vas, Ketan Dhatariya, Vickie Driver, Agnes Hartemann, Magnus Londahl, Alberto Piaggesi, Jan Apelqvist, Chris Attinger, Fran Game
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Review
Endocrinology & Metabolism
M. Westby, G. Norman, K. Vedhara, F. Game, N. Cullum
Article
Dermatology
Fran Game, Katie Gray, Daniel Davis, Rachelle Sherman, Kamal Chokkalingam, Zak Connan, Apostolos Fakis, Michael Jones
Summary: Recent reviews indicate that amniotic membrane products could potentially aid in the accelerated healing of diabetic foot ulcers. A pilot trial testing the addition of dried human amniotic membrane (dHAM) to standard care for diabetic foot ulcers showed promising results, with a higher healing rate and percentage wound area reduction in the dHAM group compared to standard care group. This suggests that dHAM preparation may be a safe and effective treatment option for diabetic foot ulcers.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Endocrinology & Metabolism
William Jeffcoate, Frances Game, Stephan Morbach, Maria Narres, Kristien Van Acker, Andrea Icks
Article
Medicine, General & Internal
Victoria Jane Hall, Sarah Foulkes, Andre Charlett, Ana Atti, Edward J. M. Monk, Ruth Simmons, Edgar Wellington, Michelle J. Cole, Ayoub Saei, Blanche Oguti, Katie Munro, Sarah Wallace, Peter D. Kirwan, Madhumita Shrotri, Amoolya Vusirikala, Sakib Rokadiya, Meaghan Kall, Maria Zambon, Mary Ramsay, Tim Brooks, Colin S. Brown, Meera A. Chand, Susan Hopkins
Summary: This study investigated whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. It found that individuals with a previous history of SARS-CoV-2 infection had an 84% lower risk of reinfection, with a median protective effect lasting for 7 months following primary infection.
Article
Medicine, General & Internal
Victoria Jane Hall, Sarah Foulkes, Ayoub Saei, Nick Andrews, Blanche Oguti, Andre Charlett, Edgar Wellington, Julia Stowe, Natalie Gillson, Ana Atti, Jasmin Islam, Ioannis Karagiannis, Katie Munro, Jameel Khawam, Meera A. Chand, Colin S. Brown, Mary Ramsay, Jamie Lopez-Bernal, Susan Hopkins
Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.
Letter
Endocrinology & Metabolism
Jonathan Valabhji, Emma Barron, Eszter P. Vamos, Ketan Dhatariya, Frances Game, Partha Kar, Andy Weaver, Sophia Verma, Bob Young, Kamlesh Khunti
Article
Endocrinology & Metabolism
Catherine Gooday, Wendy Hardeman, Frances Game, Jim Woodburn, Fiona Poland
Summary: This qualitative study aimed to understand the experiences of individuals with Charcot neuroarthropathy (CN). The study found that CN has substantial physical, social, and emotional impacts on patients and their families, including confinement at home, disruption of roles and responsibilities, pain, and self-blame. The results of this study highlight the importance of raising clinical awareness of CN.
Review
Endocrinology & Metabolism
William Jeffcoate, Fran Game
Summary: This article emphasizes the importance of the inflammation process in the development and resolution of neuropathic osteoarthropathy, pointing out that the interaction between neuropathy and inflammation is essential for the occurrence of Charcot foot.
Article
Endocrinology & Metabolism
Sicco Bus, Matilde Monteiro-Soares, Fran J. Game, Jaap van Netten, Jan Apelqvist, Robert Fitridge, Eric C. Senneville, Nicolaas Schaper
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published updated guidelines in 2023 on the prevention and management of diabetes-related foot disease. These guidelines cover various aspects such as prevention, classification, offloading, peripheral artery disease, infection, wound healing interventions, and Charcot neuro-osteoarthropathy. Implementing these guidelines by healthcare providers, public health agencies, and policymakers is expected to improve the management of diabetes-related foot disease and reduce the burden caused by this condition worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Jaap J. A. van Netten, Sicco A. Bus, Jan Apelqvist, Pam Chen, Vivienne Chuter, Robert Fitridge, Frances J. Game, Robert J. A. Hinchliffe, Peter A. Lazzarini, Joseph Mills, Matilde Monteiro-Soares, Edgar J. G. M. Peters, Katherine M. Raspovic, Eric K. Senneville, Dane K. C. Wukich, Nicolaas C. Schaper
Summary: In order to facilitate clear communication between individuals with diabetes-related foot disease and professionals worldwide, the International Working Group on the Diabetic Foot (IWGDF) has developed a set of definitions and criteria for diabetes-related foot disease based on systematic reviews of the literature. This document describes the 2023 update of these definitions and criteria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Matilde Monteiro-Soares, Emma J. J. Hamilton, David A. A. Russell, Gulapar Srisawasdi, Edward J. J. Boyko, Joseph L. L. Mills, William Jeffcoate, Fran Game
Summary: This study aimed to assess published systems used to characterise ulcers in people with diabetes in order to determine recommended systems for aiding communication between health professionals, predicting clinical outcomes, characterising patients with infection or peripheral arterial disease, and comparing outcomes in different populations. The systematic review found 28 systems, with low certainty of evidence for each classification, but provided enough evidence to support recommendations on the use of six systems in specific clinical scenarios.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Matilde Monteiro-Soares, Emma J. Hamilton, David A. Russell, Gulapar Srisawasdi, Edward J. Boyko, Joseph L. Mills, William Jeffcoate, Frances Game
Summary: This publication updates the 2019 guidelines of the International Working Group of the Diabetic Foot (IWGDF) on the use of classification systems for foot ulcers in people with diabetes in routine clinical practice. Based on a systematic review and expert consensus, specific classification systems are recommended for communicating, predicting outcomes, characterizing infected ulcers and peripheral artery disease, as well as auditing outcomes of populations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Nicolaas J. Schaper, Jaap van Netten, Jan A. Apelqvist, Sicco Bus, Robert Fitridge, Fran Game, Matilde Monteiro-Soares, Eric Senneville, IWGDF Editorial Board
Summary: The International Working Group on the Diabetic Foot (IWGDF) has updated their practical guidelines on the prevention and management of diabetes-related foot disease. These guidelines aim to reduce the frequency of lower-extremity amputations caused by diabetes-related foot disease and provide better care for patients worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Dermatology
Jennie E. Hancox, Charlotte Hilton, Katie Gray, Fran Game, Kavita Vedhara
Summary: Patients with diabetic foot ulcers often do not adhere to the advice of limiting weight-bearing activity, which is necessary for ulcers to heal. Communication of the advice, including rapport, empathy, and rationale, as well as individual factors such as daily demands, exercise enjoyment, and health benefits, influence patients' adherence. Healthcare professionals should employ a more person-centred approach tailored to patients' specific needs and consider patient priorities and constraints.
INTERNATIONAL WOUND JOURNAL
(2023)