Article
Endocrinology & Metabolism
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Moller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
Summary: The study found that hypoxemia is associated with increased prevalence of albuminuria, retinopathy, and neuropathy in type 1 diabetes, but not with cardiovascular disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Wai Kin Chan, Sung-Sheng Tsai, Yan-Rong Li, Wei-Yu Chou, Hsiao-Lien Chen, Szu-Tah Chen
Summary: The study investigated the association between serum bilirubin levels and albuminuria progression in type 2 diabetic Taiwanese, finding that higher levels of serum BIL were associated with a lower risk of albuminuria progression.
BIOMEDICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Yui Yamamoto, Ko Hanai, Tomomi Mori, Yoichi Yokoyama, Naoshi Yoshida, Hidekazu Murata, Tomohiro Shinozaki, Tetsuya Babazono
Summary: This study found that individuals with type 2 diabetes exhibiting non-albuminuric kidney insufficiency had a higher risk of kidney function decline, albuminuria, and all-cause mortality compared to those exhibiting preserved kidney function without albuminuria.
Article
Medicine, General & Internal
F. Jansson Sigfrids, E. H. Dahlstrom, C. Forsblom, N. Sandholm, V. Harjutsalo, M. -R. Taskinen, P. -H. Groop
Summary: Remnant cholesterol concentration, but not variability, predicts the progression of diabetic nephropathy and development of severe diabetic retinopathy in patients with type 1 diabetes. However, the causal relationship between remnant cholesterol and these outcomes remains to be elucidated.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Supabhorn Yimthiang, David A. Vesey, Phisit Pouyfung, Tanaporn Khamphaya, Glenda C. Gobe, Soisungwan Satarug
Summary: Chronic cadmium exposure can cause kidney damage, leading to a decline in glomerular filtration rate (GFR) and tubular proteinuria. Diabetic kidney disease (DKD) is characterized by albuminuria and declining GFR, and exposure to cadmium can worsen the progression of kidney disease in diabetics. A study involving 88 diabetics and 88 controls found that even low levels of cadmium exposure were associated with tubular dysfunction and increased risk of albuminuria, especially in individuals with a higher body burden of cadmium, hypertension, and reduced eGFR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Rosa Rodriguez-Rodriguez, Radovan Hojs, Francesco Trevisani, Enrique Morales, Gema Fernandez, Sebastjan Bevc, Clara Maria Cases Corona, Josep Maria Cruzado, Maria Quero, Maruja Navarro Diaz, Arianna Bettiga, Federico Di Marco, Marina Lopez Martinez, Francisco Moreso, Clara Garcia Garro, Khaled Khazim, Fedaa Ghanem, Manuel Praga, Meritxell Ibernon, Ivo Laranjinha, Luis Mendonca, Miguel Bigotte Vieira, Mads Hornum, Bo Feldt-Rasmussen, Beatriz Fernandez-Fernandez, Patricia Fox Concepcion, Natalia Negrin Mena, Alberto Ortiz, Esteban Porrini
Summary: The clinical-histologic correlation in diabetic nephropathy is not fully understood. Analysis of nephrectomy specimens showed weak correspondence between analytical parameters and kidney histology, suggesting disease progression may go undetected in early stages. Vascular damage was a common finding, emphasizing the role of ischemic intrarenal disease in diabetes.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Ana Huerta, Eva Merida, Laura Medina, Maria Fernandez, Eduardo Gutierrez, Eduardo Hernandez, Paula Lopez-Sanchez, Angel Sevillano, Jose Portoles, Hernan Trimarchi, Manuel Praga
Summary: Treatment with corticosteroids and mycophenolic acid analogues is effective in IgA nephropathy patients with progressive decline in kidney function accompanied by persistent proteinuria and hematuria.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Endocrinology & Metabolism
Seyed Alireza Zomorodian, Maryam Shafiee, Zeinab Karimi, Fatemeh Masjedi, Amirhossein Roshanshad
Summary: This study evaluated the relationship between vitamin D deficiency and albuminuria in patients with type 2 diabetes. The results showed a significant negative correlation between 25OHD and albuminuria, with a 25OHD level <= 21 ng/ml considered as the optimal cut-off point for macroalbuminuria in diabetic patients.
BMC ENDOCRINE DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Rajiv Agarwal, Bertram Pitt, Peter Rossing, Stefan D. Anker, Gerasimos Filippatos, Luis M. Ruilope, Csaba P. Kovesdy, Katherine Tuttle, Muthiah Vaduganathan, Christoph Wanner, Sameer Bansilal, Martin Gebel, Amer Joseph, Robert Lawatscheck, George L. Bakris
Summary: This study explored whether cardiovascular risk in patients with type 2 diabetes and chronic kidney disease can be modified with finerenone treatment. The results showed that finerenone was associated with a reduction in composite cardiovascular risk, especially in patients with eGFR of 60 or higher and UACR of 30 mg/g or greater.
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Shuoning Fan, Xueke Yang, Yingrui Yang, Zhijie Li
Summary: This study aims to explore the relationship between abnormal renal and liver function and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The study found that higher urine albumin and urine albumin/creatinine ratio were closely related to the occurrence of DR, and low total protein was associated with an increased risk of DR. The risk factor score was positively correlated with the risk of developing DR.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nobuko Kitagawa, Noriyuki Kitagawa, Emi Ushigome, Hidetaka Ushigome, Isao Yokota, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: The study found that IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports, suggesting that IH-HSBP might be a useful marker in disease prognostication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Raija Lithovius, Stefan Mutter, Erika B. Parente, Ville-Petteri Makinen, Erkka Valo, Valma Harjutsalo, Per-Henrik Groop
Summary: Effective treatment can prevent kidney complications in women with type 1 diabetes, but there may be underprescription in some cases. Data analysis of prescriptions and their relationship with kidney health can provide insights to optimize treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Article
Endocrinology & Metabolism
Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou
Summary: This study investigated the association of soluble Tumour Necrosis Factor Receptor 1 (sTNF-R1), sTNF-R2, and endostatin with new onset microalbuminuria in patients with type 2 diabetes. The results showed that endostatin and sTNF-R1 were increased at baseline, but sTNF-R2 did not increase. However, these factors were not effective in predicting the occurrence of microalbuminuria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, Research & Experimental
Isabel Cristina Mallostro Emerich de Abreu, Raquel Cristina Melo Ferreira de Albuquerque, Ana Beatriz Pereira Brandao, Leticia Barssotti, Livia Bruni de Souza, Fabiana Gomes Ferreira, Lilian Caroline Goncalves de Oliveira, Rodrigo Yokota, Luiz Gustavo Sparvoli, Danielle da Silva Dias, Miguel Angel Castillo Salgado, Carla Taddei, Katia De Angelis, Dulce Elena Casarini, Tatiana Sousa Cunha
Summary: Probiotic administration with Saccharomyces boulardii improved kidney structure and function in streptozotocin-induced diabetic mice, which is associated with modulation of intestinal microbiota.
Article
Endocrinology & Metabolism
Feng-Chih Shen, Shao-Wen Weng, Meng-Han Tsai, Yu-Jih Su, Sung-Chou Li, Shun-Jen Chang, Jung-Fu Chen, Yen-Hsiang Chang, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Ching-Yi Lin, Pei-Wen Wang
Summary: Mitochondrial haplogroups have a significant impact on the clinical characteristics of type 2 diabetes, with patients carrying the D4 haplogroup being less likely to require insulin treatment compared to those with non-D4 haplotypes. However, there is no significant association between insulin requirement and genetic variants in nuclear DNA. This highlights the role of mitochondria in the management of common metabolic diseases.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Editorial Material
Surgery
Chong-Chi Chiu, Po-Huang Lee, Chen-Fuh Lam, Li-Ren Yeh, Cheuk-Kwan Sun
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Health Care Sciences & Services
Nai-Ching Chen, Chien-Liang Chen, Feng-Chih Shen
Summary: This study found that the drug regimen affects hypoglycemic episodes in older patients with dementia and T2DM. However, HbA1c levels are not correlated with hypoglycemic events. Patients with more comorbidities have an increased risk of hypoglycemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Shao-Wen Weng, Wen-Chieh Chen, Feng-Chih Shen, Pei-Wen Wang, Jung-Fu Chen, Chia-Wei Liou
Summary: The study found a significant association between serum GDF15 levels and diabetic metabolism characteristics and diabetic neuropathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Anesthesiology
Kuo-Chuan Hung, Ching-Chung Ko, Chih-Wei Hsu, Yu-Li Pang, Jen-Yin Chen, Cheuk-Kwan Sun
Summary: This systematic review and meta-analysis investigated the impact of peripheral nerve blocks (PNBs) on patient-reported quality of recovery (QoR) following breast cancer surgery. The results showed that patients who received PNBs had higher QoR scores at 24 hours after surgery, as well as higher scores on all subscales of the QoR-40 scale except for psychological support. Sensitivity analysis confirmed the stability of the results. The use of PNBs was associated with lower opioid consumption and a lower risk of postoperative nausea and vomiting.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang
Summary: In this study, the lupus murine model focused on the TLR7 pathway was activated through the MDA5 signaling pathway in splenic B cells, which plays a crucial role in the detection of viral infections and autoimmunity. Further investigation on MDA5 agonist/antagonist RNAs and detailed molecular interactions within B cells is warranted for lupus therapy.
Review
Environmental Sciences
Hsiu-Man Lin, Yu-Tzu Chang, Meng-Hsiang Chen, Shu-Tsen Liu, Bo-Shen Chen, Lin Li, Chiao-Yu Lee, Yu-Ru Sue, Tsai-Mei Sung, Cheuk-Kwan Sun, Pin-Yang Yeh
Summary: This study found a potential association between excessive smartphone use and reduced brain volume and altered activations, especially in subcortical regions. Adolescents were more susceptible to these effects. Additionally, there was a positive correlation between impulsivity and volume reduction.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Psychology, Developmental
Kuo-Chuan Hung, Jen-Yin Chen, Chung-Hsi Hsing, Chih-Wei Hsu, Ping-Hsin Liu, Ying-Jen Chang, Jui-Yi Chen, Sheng-Fu Chiu, Cheuk-Kwan Sun
Summary: This meta-analysis investigated the association between labor epidural analgesia exposure and the risk of autism spectrum disorder in offspring. The results showed a slightly increased risk of autism spectrum disorder in children with exposure to labor epidural analgesia compared to those without. This finding was consistent in subgroup analysis focusing on sibling data and children delivered vaginally. However, no increased risk of autism spectrum disorder was observed in children exposed to labor epidural analgesia for less than 4 hours or more than 8 hours.
Review
Medicine, General & Internal
Kuo-Chuan Hung, Yu-Yu Li, Yen-Ta Huang, Ping-Hsin Liu, Chih-Wei Hsu, Chun-Ning Ho, I-Yin Hung, Fu-Sheng Chang, Cheuk-Kwan Sun
Summary: A meta-analysis found a positive correlation between blood urea nitrogen (BUN)/albumin ratio and poor outcome in patients with COVID-19. High BUN/Albumin ratio is associated with increased risk of poor prognosis.
Letter
Endocrinology & Metabolism
Yu-Hsuan Pai, Renin Chang, Cheuk-Kwan Sun, Wen-Bin Yeh
DIABETES & METABOLISM
(2023)
Review
Psychiatry
Hsien-Jane Chiu, Cheuk-Kwan Sun, Yu-Shian Cheng, Ming Yu Wang, Ruu-Fen Tzang, Feng-Li Lin, Ying-Chih Cheng, Weilun Chung
Summary: A meta-analysis of nine randomized controlled trials demonstrated that psychostimulants may be effective in treating symptoms of ADHD in preschool children, especially hyperactivity/impulsivity as observed by teachers. However, the quality of the evidence was low, and further research is needed to confirm the true magnitude of the effect.
EUROPEAN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Kuo-Chuan Hung, Chun-Ning Ho, Wei-Cheng Liu, Ming Yew, Ying-Jen Chang, Yao-Tsung Lin, I-Yin Hung, Jen-Yin Chen, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: This study aimed to provide updated evidence on the association between intraoperative lidocaine and the risk of postcardiac surgery cognitive deficit. The results suggested a prophylactic effect of intravenous lidocaine against cognitive deficit in the early postoperative period, but insufficient evidence to support this conclusion. In the late postoperative period, intravenous lidocaine did not reduce the risk of cognitive deficit. Intravenous lidocaine may be associated with a shortened length of stay in the intensive care unit/hospital, but the evidence is weak. Further large-scale studies are needed to evaluate the use of lidocaine for the prevention of cognitive deficit and enhancement of recovery.
Review
Medicine, General & Internal
I-Wen Chen, Yu-Yu Li, Kuo-Chuan Hung, Ying-Jen Chang, Jen-Yin Chen, Ming-Chung Lin, Kuei-Fen Wang, Chien-Ming Lin, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: By comparing the outcomes of video-stylets and conventional laryngoscopes in tracheal intubation of patients with cervical immobilization, the study found no significant differences in intubation success rate, time, and risk of tissue damage between the two, but video-stylets had a lower risk of causing sore throat.