Article
Multidisciplinary Sciences
Prabha H. Andraweera, Michelle D. Plummer, Amy Garrett, Shalem Leemaqz, Melanie R. Wittwer, Emily Aldridge, Maleesa M. Pathirana, Gus A. Dekker, Claire T. Roberts, Margaret A. Arstall
Summary: This study aimed to compare the risk factors for cardiovascular disease (CVD) 10 years after childbirth between women with >= 1 cardio metabolic risk factor in early first pregnancy and those with no risk factors. The results showed that women with >= 1 risk factor during the first pregnancy were 5.5 times more likely to have metabolic syndrome 10 years postpartum and had higher risks of obesity, elevated total cholesterol levels, and increased insulin resistance. Therefore, identifying cardio metabolic risk factors in early pregnancy may help identify young women at risk of future CVD.
Article
Nutrition & Dietetics
Katarzyna Bergmann, Anna Stefanska, Magdalena Krintus, Lukasz Szternel, Wojciech J. Bilinski, Przemyslaw T. Paradowski, Grazyna Sypniewska
Summary: This study aimed to assess the diagnostic accuracy of biomarker-based scores for predicting MAFLD in apparently healthy children. The results showed that P1NP/ALPxCRP was significantly elevated in MAFLD patients and had better predictive capability in boys. Therefore, we suggest that P1NP/ALPxCRP can be used as a reliable tool for MAFLD prediction in routine pediatric practice.
Article
Endocrinology & Metabolism
Nathalie Bourcigaux, Emma Dubost, Jean-Claude Buzzi, Bruno Donadille, Christophe Corpechot, Armelle Poujol-Robert, Sophie Christin-Maitre
Summary: A high prevalence of liver function abnormalities (LFAs) was found in adult patients with Turner syndrome (TS), with 42.8% of patients affected. About 10% of these patients were at high risk of developing fibrosis. The FIB-4 score is a useful tool for assessing liver impairment and should be included in routine screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Min Jeong Park, Kyung Mook Choi
Summary: Despite efforts to improve cardiovascular disease (CVD) risk factors, there is still residual risk even in patients reaching treatment targets. Recent research has focused on the variability of metabolic variables as a way to reduce this residual risk. This literature review explores the relationship between metabolic factor variability and CVD risk, and discusses potential mechanisms and treatment perspectives for reducing cardiometabolic risk factor variability.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Li Qin, Junru Wu, Xuejing Sun, Xuewei Huang, Wei Huang, Chunyan Weng, Jingjing Cai
Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by excessive fat accumulation in the liver, affecting about a quarter of the global population. Recent studies have found a high prevalence of cardiovascular disease (CVD) in NAFLD patients, but the underlying mechanisms are still unclear. This review summarizes the relationship between metabolic organ-secreted factors and NAFLD and CVD, aiming to enhance clinicians' understanding of these diseases and improve cardiovascular outcomes in NAFLD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Ilya Querter, Nele S. Pauwels, Ruth De Bruyne, Ellen Dupont, Xavier Verhelst, Lindsey Devisscher, Hans Van Vlierberghe, Anja Geerts, Sander Lefere
Summary: Maternal prepregnancy overweight and obesity are associated with an increased risk of pediatric NAFLD. Breastfeeding might be protective against the development of NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Jasmin de Groot, Susana Santos, Madelon L. Geurtsen, Janine F. Felix, Vincent W. V. Jaddoe
Summary: In this study conducted in the Netherlands, it was found that over half of children had liver fat percentage exceeding 2%, and 25.2% met the criteria for MAFLD. Only non-European descent was associated with childhood MAFLD. Children with MAFLD had increased likelihood of cardiometabolic-risk-factor clustering compared to those with liver fat percentage <2%.
Review
Biology
Zhongjie Fu, Anders K. Nilsson, Ann Hellstrom, Lois E. H. Smith
Summary: Retinopathy of prematurity (ROP) is caused by the suppression of physiological retinal vascular development, leading to compensatory but pathological neovascularization. Promoting normal vessel growth can prevent ROP. Early perinatal metabolic dysregulation is a risk factor for ROP and other long-term sequelae. Controlling postnatal hyperglycemia, dyslipidemia, and hyperoxia can promote normal retinal development.
Review
Biochemistry & Molecular Biology
Gina Papadopoulou, Georgina Xanthou
Summary: Th17 cells, characterized by plasticity and both pathogenic and tissue-protective functions, rely heavily on metabolic reprogramming which can influence autoimmune, inflammatory, and antitumor responses. Understanding these molecular mechanisms may lead to novel therapeutic interventions for managing tissue inflammation, autoimmune disorders, and cancer.
Article
Gastroenterology & Hepatology
Min Kyu Kang, Yu Rim Lee, Se Young Jang, Won Young Tak, Young Oh Kweon, Jeong Eun Song, Rohit Loomba, Soo Young Park, Jung Gil Park
Summary: The study aims to evaluate the association of cardiovascular risk in two terminologies (NAFLD and MAFLD) and subgroups of MAFLD. The results showed that both NAFLD and MAFLD were significantly associated with coronary artery calcification (CAC), but only MAFLD remained associated with CAC after adjusting for sex and age. Diabetic MAFLD predicted high-risk CVD phenotypes the best, while metabolic risk abnormalities in nondiabetic MAFLD patients were also independently associated with the risk of CVD.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Meilin Ma, Changhui Zhang, Rong Cao, Dongmei Tang, Xiongbo Sang, Sailan Zou, Xiuxuan Wang, Haixia Xu, Geng Liu, Lunzhi Dai, Yan Tian, Xiang Gao, Xianghui Fu
Summary: This study reveals the importance of UBE2O in the development of hepatocellular carcinoma (HCC). UBE2O is found to be highly expressed in HCC tumors and is associated with poor survival prognosis. It regulates lipid metabolic reprogramming by modulating the ubiquitination and degradation of HADHA, a mitochondrial enzyme. Furthermore, UBE2O deletion in mice inhibits hepatocarcinogenesis and reduces hepatic lipid accumulation.
Review
Multidisciplinary Sciences
George Agyapong, Farzaneh Dashti, Bubu A. A. Banini
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. This manuscript provides an overview of NAFLD risk factors, natural history, diagnosis, and current management strategies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Juan Carlos Rodriguez-Duque, Jose Luis Calleja, Paula Iruzubieta, Marta Hernandez-Conde, Coral Rivas-Rivas, Maria Isabel Vera, Maria Jose Garcia, Marta Pascual, Beatriz Castro, Agustin Garcia-Blanco, Enrique Garcia-Nieto, Soraya Curiel-del Olmo, Maria Luisa Cagigal, Lorena Lopez-Montejo, Tatiana Fernandez-Lamas, Laura Rasines, Jose Ignacio Fortea, Jose Pedro Vaque, Yza Frias, Montserrat Rivero, Maria Teresa Arias-Loste, Javier Crespo
Summary: This study investigated the prevalence and risk factors of metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). The results showed that the prevalence of MAFLD and liver fibrosis was significantly higher in IBD patients compared to the general population, independent of traditional metabolic risk factors. This study is important for understanding the liver health of IBD patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Lucas Fornari Laurindo, Sandra Maria Barbalho, Alexis R. Marquess, Annik Ianara de Souza Grecco, Ricardo de Alvares Goulart, Ricardo Jose Tofano, Anupam Bishayee
Summary: This review evaluates the potential of pomegranate in reducing metabolic syndrome risk factors. The studies suggest that pomegranate can reduce body weight, blood pressure, glycemia, lipid levels, and improve insulin resistance.
Review
Biochemistry & Molecular Biology
Rolf Teschke, Gaby Danan
Summary: Progress has been made in understanding the mechanisms of idiosyncratic drug-induced liver injury (iDILI) worldwide, with the identification of metabolic risk factors. However, uncertainty remains regarding the prediction of iDILI, with controversies surrounding certain risks factors such as drug doses and hepatic drug metabolism. Further research is needed to address these methodological flaws and establish stronger evidence for risk factors of iDILI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Obstetrics & Gynecology
A. Mandelli, E. Tacconi, I Levinger, G. Duque, A. Hayes
Summary: Osteoporosis and sarcopenia are two aging-related conditions characterized by a decline in bone and muscle mass, respectively. They share common risk factors and biological pathways, which form a syndrome known as osteosarcopenia. Estrogens play a critical role in the development and maintenance of bone and muscle, with hormonal therapy showing positive effects on osteoporosis but still disputable effects on sarcopenia.
Review
Endocrinology & Metabolism
Melpomeni Malamouli, Itamar Levinger, Andrew J. McAinch, Adam J. Trewin, Raymond J. Rodgers, Alba Moreno-Asso
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in pre-menopausal women with metabolic dysregulation. While exercise, especially high-intensity interval training (HIIT), is recommended as the first-line therapy for PCOS, the understanding of mitochondrial characteristics and their role in PCOS pathogenesis is limited. Further comprehensive studies are needed to investigate the association between metabolic dysfunction and aberrant mitochondrial profile, and to understand the molecular mechanisms underlying exercise-induced metabolic adaptations in women with PCOS.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Summary: This study revealed a causal link between increased NPY-Y1 receptor gene expression in human T2D and beta-cell dysfunction and failure, indicating that the inhibition of the Y1 receptor may improve beta-cell function and protect beta-cell mass in T2D patients for better glycemic control.
MOLECULAR METABOLISM
(2022)
Article
Obstetrics & Gynecology
Rhiannon K. Patten, Luke C. McIlvenna, Itamar Levinger, Andrew P. Garnham, Soulmaz Shorakae, Alexandra G. Parker, Andrew J. McAinch, Raymond J. Rodgers, Danielle Hiam, Alba Moreno-Asso, Nigel K. Stepto
Summary: This study compares the effects of high-intensity interval training (HIIT) and standard moderate-intensity continuous training (MICT) on cardio-metabolic and reproductive outcomes in women with polycystic ovary syndrome (PCOS). The results show that HIIT leads to greater improvements in aerobic capacity, insulin sensitivity, menstrual cyclicity, and reductions in hyperandrogenism compared to MICT. The findings suggest that HIIT may be a more beneficial strategy for promoting health and reducing cardio-metabolic risk in overweight women with PCOS.
HUMAN REPRODUCTION
(2022)
Review
Physiology
C. David Hughes, P. Justin Hardee, S. David Waddell, A. Craig Goodman
Summary: Gene delivery strategy has been used to study muscular disorders and muscle physiology. This review provides a detailed protocol on how to efficiently electroporate plasmid DNA into rodent skeletal muscles, discussing key parameters and tissue processing methods.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Simon Sostaric, Aaron C. Petersen, Craig A. Goodman, Xiaofei Gong, Tai-Juan Aw, Malcolm J. Brown, Andrew Garnham, Collene H. Steward, Kate T. Murphy, Kate A. Carey, James Leppik, Steve F. Fraser, David Cameron-Smith, Henry Krum, Rodney J. Snow, Michael J. McKenna
Summary: This study investigated the effects of digoxin on muscle Na+,K+-ATPase (NKA), and found that it led to decreased muscle strength without affecting muscle NKA content and fatiguability.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Environmental Sciences
Shraddha Shah, Grace Dibben, Aditi Ketkar, David L. Hare, Jonathan Myers, Barry Franklin, Abraham Samuel Babu, Rod S. Taylor
Summary: Coronary artery disease (CAD) is a leading cause of mortality and morbidity. Exercise-based cardiac rehabilitation (EBCR) has been shown to improve clinical outcomes in these patients. This systematic review and network meta-analysis aim to determine the optimal dose of exercise training interventions to improve exercise capacity and quality of life in CAD patients. The findings of this study will help clinicians and cardiac rehabilitation specialists in making informed decisions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Qiang Tu, Karice Hyun, Nashid Hafiz, Andrew Knight, Charlotte Hespe, Clara K. Chow, Tom Briffa, Robyn Gallagher, Christopher M. Reid, David L. Hare, Nicholas Zwar, Mark Woodward, Stephen Jan, Emily R. Atkins, Tracey-Lea Laba, Elizabeth Halcomb, Tim Usherwood, Laurent Billot, Julie Redfern
Summary: The study investigated age-related variations in provision of primary care services and pharmacological therapy for patients with CVD, revealing differences in management plans, mental health care, cardiovascular medications, and influenza vaccination across different age groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Garry W. Hamilton, Jaishankar Raman, Simon Moten, George Matalanis, Alexander Rosalion, Arnaldo Dimagli, Siven Seevanayagam, Mario F. Gaudino, David L. Hare, RAPCO Investigators
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
David L. Hare
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Tabitha Cree, Tania Ruz Gomez, Cara A. Timpani, Emma Rybalka, John T. Price, Craig A. Goodman
Summary: FKBP25 is a dual-domain PPIase protein that binds to microtubules and may have an impact on microtubule polymerization and cell cycle progression. A recent study showed that FKBP25 is highly expressed in mouse skeletal muscle. This study aimed to investigate the role of FKBP25 in myoblast viability, migration, differentiation, and muscle adaptation. The findings suggest that FKBP25 regulates myoblast viability and migration and may play a role in muscle regeneration and adaptation.
Article
Neurosciences
Xuzhu Lin, Cassandra Smith, Alba Moreno-Asso, Navabeh Zarekookandeh, Tara C. Brennan-Speranza, Gustavo Duque, Alan Hayes, Itamar Levinger
Summary: This study investigates the protective effects of the combination of undercarboxylated osteocalcin (ucOC) and ibandronate (IBN) against immobilization-induced muscle wasting and insulin resistance. The results show that the combined treatment significantly increases muscle weight and improves glucose tolerance compared to individual treatments.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Endocrinology & Metabolism
Cassandra Smith, Marc Sim, Jack Dalla Via, Itamar Levinger, Gustavo Duque
Summary: Loss of muscle and bone mass, strength, and quality, which commonly occur with aging, can lead to reduced physical function and increased risk of falls and fractures. The interaction between bone and muscle, driven by bone-muscle crosstalk, plays a crucial role in this process. Exercise is the primary strategy for improving both muscle and bone health. However, holistic treatment plans that incorporate exercise and other allied health services are underutilized in preventing or treating musculoskeletal diseases.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Cell Biology
Hannah Lalunio, Lewan Parker, Erik D. Hanson, Paul Gregorevic, Itamar Levinger, Alan Hayes, Craig A. Goodman
Summary: Vitamin D and its receptor (VDR) play important roles in muscle development and function. This study investigated the differences in VDR protein abundance in muscle between different mouse strains and between mice and humans, using different sample preparation methods and antibodies. The findings showed differences in VDR protein levels among mouse strains and between mice and humans, and the detection of potential VDR isoforms in human muscle.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Alexandra Parker, Sarah Dash, Matthew Bourke, Rhiannon Patten, Melinda Craike, Peter Baldwin, Warwick Hosking, Itamar Levinger, Vasso Apostolopoulos, Maximilian de Courten, Jenny Sharples, Monika Naslund, Vasileios Stavropoulos, Mary Woessner, Christopher Sonn, Caroline Stansen, Michaela Pascoe
Summary: The aim of this study was to determine the acceptability and preliminary outcomes of a daily online mental health promotion program for tertiary education staff during the COVID-19 pandemic. The program provided microinterventions comprising lifestyle and well-being strategies to promote mental health via an online meeting platform. Results showed that participants reported high levels of satisfaction with sessions and perceived benefits for mental health.
JMIR FORMATIVE RESEARCH
(2022)