Article
Cardiac & Cardiovascular Systems
Laura D'Erasmo, Michele Di Martino, Thomas Neufeld, Tyler J. Fraum, Chul Joo Kang, Kendall H. Burks, Alessia Di Costanzo, Ilenia Minicocci, Simone Bini, Marianna Maranghi, Giovanni Pigna, Giancarlo Labbadia, Jie Zheng, Davide Fierro, Anna Montali, Fabrizio Ceci, Carlo Catalano, Nicholas O. Davidson, Giuseppe Lucisano, Antonio Nicolucci, Marcello Arca, Nathan O. Stitziel
Summary: The study recruited participants with ANGPTL3 deficiency related to gene mutations as well as those with genetically determined reduction in plasma ANGPTL3 levels, showing that these conditions are not associated with increased risk of hepatic steatosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sai Man Cheung, Ehab Husain, Vasiliki Mallikourti, Yazan Masannat, Steven Heys, Jiabao He
Summary: Lipid composition may serve as a biomarker for studying lymphovascular invasion in breast cancer.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo De Robertis, Flavio Spoto, Daniele Autelitano, Daniela Guagenti, Antonia Olivieri, Piero Zanutto, Greta Incarbone, Mirko D'Onofrio
Summary: This study compared the efficacy of ultrasound (US) and US-derived fat fraction (UDFF) with magnetic resonance proton density fat fraction (MRI-PDFF) in detecting hepatic steatosis and quantifying liver fat content. The results showed that UDFF can reliably quantify liver fat content and improve the diagnostic value of US for detecting hepatic steatosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel A. P. Gutmann, Susanne Rospleszcz, Wolfgang Rathmann, Christopher L. Schlett, Annette Peters, Christian Wachinger, Sergios Gatidis, Fabian Bamberg
Summary: By investigating the radiomics features of hepatic fat, potential imaging biomarkers for T2DM and MetS can be identified, showing good predictive performance and outperforming RF models trained on benchmark parameters PDFF and BMI.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Owen T. T. Carmichael, Maninder Singh, Adil Bashir, Anne M. M. Russell, Mark Bolding, David T. T. Redden, Judd Storrs, William R. R. Willoughby, Candace Howard-Claudio, Daniel S. S. Hsia, Robert P. P. Kimberly, Meagan E. E. Gray, Eric Ravussin, Thomas S. S. Denney
Summary: The goal of this study was to harmonize 3T magnetic resonance imaging measurements in obese individuals across different academic sites and MRI vendors. The results showed high repeatability of the measurements of liver fat and stiffness in both humans and phantoms. This study demonstrates that multisite MRI harmonization could improve the assessment of interventions and therapy for NAFLD in multisite clinical trials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Seung Soo Lee, Na Young Kim, Hyo Jung Park, Yu Sub Sung, Yedaun Lee, Jee Seok Yoon, Heung-Il Suk
Summary: This study aimed to evaluate the impact of hepatic steatosis (HS) on liver volume and develop a formula to estimate lean liver volume after correcting for the effect of HS. The results showed that HS was positively associated with liver volume and a formula was proposed to estimate PDFF-adjusted lean liver volume, which can be used to account for the effect of HS on liver volume.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ayhan Gursan, Jeanine J. Prompers
Summary: The liver is crucial for glucose homeostasis and MRI and MRS techniques provide unique insights into liver glucose metabolism in both healthy individuals and those with metabolic diseases such as diabetes.
Article
Medicine, General & Internal
Li-Shan Shen, Quan-Xi Li, Xiao-Wen Luo, Hui-Jun Tang, You-Jie Tang, Wen-Jie Tang, Ruo-Mi Guo
Summary: Using magnetic resonance imaging-determined proton density fat fraction (PDFF), there is a high correlation between liver fat content and hepatic perfusion disorders (HPD) after radiofrequency ablation (RFA) for liver cancer. Higher liver fat content increases the risk of hyperperfusion abnormalities, but has little impact on hypoperfusion abnormalities.
Review
Medicine, General & Internal
Duanghathai Pasanta, Khin Thandar Htun, Jie Pan, Montree Tungjai, Siriprapa Kaewjaeng, Hongjoo Kim, Jakrapong Kaewkhao, Suchart Kothan
Summary: Magnetic resonance spectroscopy (MRS) is a powerful tool for noninvasively assessing liver fat, demonstrating excellent performance with high sensitivity and specificity. It is generally accepted as the reference standard for noninvasive measurement of liver steatosis, showing high potential as a diagnostic tool in the clinical setting.
Article
Microbiology
Henry H. Le, Min-Ting Lee, Kevin R. Besler, Elizabeth L. Johnson
Summary: Microbially-derived gut metabolites play an important role in host phenotypes. This study traces bacterial sphingolipids from gut symbiont Bacteroides thetaiotaomicron to mouse colons and livers, and finds that bacterial sphingolipid synthesis can rescue excess lipid accumulation in a mouse model of hepatic steatosis. The transfer of this sphingolipid to the liver potentially contributes to microbiota-mediated liver function.
CELL HOST & MICROBE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianfeng Bao, Zongye Li, Yue Zhang, Yuchuan Zhuang, Ying Li, Xiao Wang, Yanan Ren, Peipei Wang, Yong Zhang, Jingliang Cheng
Summary: Through the analysis of bone marrow in postmenopausal osteoporosis patients and healthy controls, we found that the levels of unsaturated fatty acids were lower in the bone marrow of postmenopausal osteoporosis patients, while saturated fatty acids were higher. In addition, the reduced unsaturated fatty acids were negatively correlated with bone density, while increased saturated fatty acids were positively correlated with bone density.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Gastroenterology & Hepatology
Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Hila Zelicha, Alon Kaplan, Philip Rosen, Ilan Shelef, Ilan Youngster, Aryeh Shalev, Matthias Bluher, Uta Ceglarek, Michael Stumvoll, Kieran Tuohy, Camilla Diotallevi, Urska Vrhovsek, Frank Hu, Meir Stampfer, Iris Shai
Summary: The study found that a green-Mediterranean diet (MED) is more effective in reducing non-alcoholic fatty liver disease (NAFLD), with a greater decrease in intrahepatic fat (IHF) content, by further restricting red/processed meat and increasing intake of green plants and polyphenols. This healthy dietary strategy shows promising results in reducing IHF and decreasing NAFLD prevalence.
Article
Medicine, General & Internal
Claudia Fellner, Marcel Dominik Nickel, Stephan Kannengiesser, Niklas Verloh, Christian Stroszczynski, Michael Haimerl, Lukas Luerken
Summary: This study evaluated the potential of water-fat separated T1 mapping in liver MRI and found that T1_W can effectively minimize the influence of fat on liver T1 values. Additionally, there was a significant correlation between retrospectively calculated T1_W (T1_W_calc) based on T1_in and PDFF.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Woo Kim, Chang Hee Lee, Zepa Yang, Baek-Hui Kim, Young-Sun Lee, Kyeong Ah Kim
Summary: This study compared the correlation between hepatic fat fraction measured by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) with two different histopathologic methods. The results demonstrated a strong correlation between MRI-PDFF and MRS, as well as with the histopathologic measurements. The diagnostic performance of MRI-PDFF and MRS for grading hepatic steatosis was also evaluated, showing promising results.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Hupfeld, Dennis Pischel, Doerthe Jechorek, Andrea Janicova, Maciej Pech, Frank Fischbach
Summary: The purpose of the study was to assess the clinical applicability of commercially available solutions for MR-based quantification of hepatic fat fraction and to compare their results with clinically established imaging methods. The findings showed that IP/OP imaging had a strong correlation with fAH, while multi-gradient echo imaging and multi-echo spectroscopy quantifications were insensitive to increased LIC. Both postprocessing solutions need improvement in segmentation quality and workflow, but all solutions are capable of bringing MRI-based hepatic fat quantification into clinical application.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Francesca Zerbini, Gianluca Perseghin
Summary: This study investigated the distribution of sNfL levels and its association with diabetes in the general US population. The results showed that patients with diabetes had higher sNfL levels, and higher sNfL levels were associated with worse cognitive function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Acoustics
Anna Palmisano, Davide Vignale, Elisa Bruno, Giovanni Peretto, Giacomo De Luca, Corrado Campochiaro, Alessandro Tomelleri, Eustachio Agricola, Matteo Montorfano, Antonio Esposito
Summary: In this study, CMR findings in patients with myocarditis-like syndrome during the acute and post-acute phase of COVID-19 were reported. The majority of cases were confirmed as myocarditis by CMR, with mild extent of lesions. Additionally, some patients had myocardial infarction and cardiomyopathies. CMR can improve diagnostic accuracy and evaluate subclinical cardiomyopathies.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Gastroenterology & Hepatology
Stefano Ciardullo, Gianluca Perseghin
Summary: Using data from the National Health and Nutrition Examination Survey, the authors applied the Fibrotic NASH Index (FNI) to estimate the prevalence of fibrotic non-alcoholic steatohepatitis (NASH) in the US population. They found that the prevalence of probable fibrotic NASH was 8.4%, with higher rates in males and Hispanic participants. The study also revealed an increasing trend in NASH prevalence, which is associated with rising rates of obesity and type 2 diabetes.
LIVER INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
Summary: This study aims to report the prevalence of fibrotic NASH in the general US population and evaluate the performance of the Fibrotic NASH Index (FNI). The study found that FNI had good accuracy in predicting probable fibrotic NASH in the overall population and in individuals with diabetes. This suggests that FNI is a simple and reliable test for screening NASH.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Rosa Cannistraci, Silvia Perra, Guido Lattuada, Gianluca Perseghin
Summary: This study analyzes data from a national survey and finds an association between 25(OH)D levels and NAFLD and liver fibrosis, suggesting a potential role of vitamin D in the occurrence and progression of NAFLD.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Vignale, Anna Palmisano, Chiara Gnasso, Davide Margonato, Davide Romagnolo, Simone Barbieri, Giacomo Ingallina, Stefano Stella, Marco Bruno Ancona, Matteo Montorfano, Francesco Maisano, Eustachio Agricola, Antonio Esposito
Summary: The prognostic value of the interstitial fibrosis marker ECV measured at planning CT before TAVI was assessed. The study found that ECV higher than 31.3% was associated with an increased risk of heart failure hospitalization or death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Castoldi, Raffaella Carletti, Silvia Ippolito, Massimiliano Colzani, Sara Pelucchi, Gianpaolo Zerbini, Gianluca Perseghin, Giovanni Zatti, Cira R. T. di Gioia
Summary: This study investigates the potential mechanisms underlying the cardioprotective effects of the SGLT2 inhibitor empagliflozin, independent of glycemic control. The results suggest that the protective effects may be associated with a reduction in myocardial sympathetic activity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Gianluca Perseghin
Summary: This systematic review and meta-analysis found an association between liver stiffness measurement (LSM) obtained through vibration-controlled transient elastography (VCTE) and all-cause mortality in patients with nonalcoholic fatty liver disease (NAFLD). The analysis showed that higher LSM, indicating liver fibrosis, is independently associated with a higher mortality risk in NAFLD patients.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Stefano Ciardullo, Francesca Zerbini, Rosa Cannistraci, Emanuele Muraca, Silvia Perra, Alice Oltolini, Gianluca Perseghin
Summary: Sex hormones have different impacts on body composition in men and women. This study aimed to evaluate the association between testosterone, estradiol, and body fat distribution in the general population. The results showed that testosterone was positively associated with lean body mass and negatively associated with fat mass and the android/gynoid ratio in men, while estradiol showed the opposite trend. Among women, testosterone did not have an impact on body composition, but estradiol was positively associated with lean mass and negatively associated with fat mass. These findings highlight the varying effects of sex hormones on specific fat depots between men and women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Stefano Ciardullo, Michela Vergani, Gianluca Perseghin
Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic dysfunction-associated steatotic liver disease (MASLD), is common in patients with type 2 diabetes (T2D) and can lead to advanced liver fibrosis. Patients with T2D have an increased risk of liver-related complications and mortality. Screening for NAFLD/MASLD and advanced liver fibrosis is recommended in T2D patients. While there are no approved drugs for NAFLD/MASLD, certain antidiabetic drugs have shown positive effects on liver health. Diabetologists have the opportunity to actively treat NAFLD/MASLD and potentially change its natural course.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Sabrina Gloria Giulia Testoni, Claudia Minici, Elisa Benetti, Francesca Clemente, Daniela Boselli, Clara Sciorati, Lucia De Monte, Maria Chiara Petrone, Markus Enderle, Walter Linzenbold, Maria Pia Protti, Angelo Manfredi, Francesco De Cobelli, Michele Reni, Massimo Falconi, Gabriele Capurso, Paolo Giorgio Arcidiacono, Emanuel Della-Torre
Summary: Thermal ablation under endoscopic ultrasound (EUS)-guidance has shown potential to enhance immune response in pancreatic ductal adenocarcinoma (PDAC). In a recent trial, EUS-guided ablation with HybridTherm Probe (HTP) in combination with chemotherapy improved disease progression compared to chemotherapy alone. This study explored the effects of EUS-HTP on systemic immune response in PDAC and found that it selectively affected immunological predictors of poor outcome.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Davide Vignale, Anna Palmisano, Caterina Colantoni, Lisa Brunetti, Valeria Nicoletti, Chiara Gnasso, Antonio Esposito
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Palmisano, Corrado Campochiaro, Davide Vignale, Alessandro Tomelleri, Giacomo De Luca, Elisa Bruno, Caterina B. Monti, Giulio Cavalli, Lorenzo Dagna, Antonio Esposito
Summary: AV groove localization in ECD patients is associated with LV wall fibrosis in downstream coronary territories, while atrial pseudomass localization impacts atrial contractility and is associated with atrio-caval junction stenosis.
Review
Radiology, Nuclear Medicine & Medical Imaging
Antonio Esposito, Marco Gatti, Maria Giovanna Trivieri, Eustachio Agricola, Giovanni Peretto, Guglielmo Gallone, Federica Catapano, Silvia Pradella, Ana Devesa, Elisa Bruno, Giorgio Fiore, Marco Francone, Anna Palmisano
Summary: Mitral valve prolapse is the most common valve disease in the western world and has recently been associated with sudden cardiac death. Echocardiography plays a crucial role in diagnosis and assessment of MVP, while cardiac magnetic resonance provides comprehensive risk stratification.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Alessandro Roberto Dodesini, Giuseppe Lepore, Anna Corsi, Cristiana Scaranna, Gianluca Perseghin, Roberto Trevisan
Summary: A model of insulin sensitivity was developed using clinical and laboratory parameters in patients with type 2 diabetes, and it was found to be associated with all-cause and cardiovascular mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)