Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of theCDKN1A(p21WAF1/CIP1) andSIRT1genes

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival

(2014) Zhe Zhu et al.   Cell Stem Cell

ERRαaugments HIF-1 signalling by directly interacting with HIF-1αin normoxic and hypoxic prostate cancer cells

(2014) Chang Zou et al.   JOURNAL OF PATHOLOGY

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable

(2014) Cindy Benod et al.   PLoS One

The Nuclear Receptor TLX Is Required for Gliomagenesis within the Adult Neurogenic Niche

(2012) Y. Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells

(2012) Jenna D. Lovaas et al.   PROSTATE

TLX controls angiogenesis through interaction with the von Hippel-Lindau protein

(2012) Z.-j. Zeng et al.   Biology Open

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Activation of Postnatal Neural Stem Cells Requires Nuclear Receptor TLX

(2011) W. Niu et al.   JOURNAL OF NEUROSCIENCE

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer

(2011) I. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation

(2010) H. K. Liu et al.   GENES & DEVELOPMENT

Nuclear Orphan Receptor TLX Induces Oct-3/4 for the Survival and Maintenance of Adult Hippocampal Progenitors upon Hypoxia

(2010) Pavithra Lakshminarasimhan Chavali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

(2010) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

(2010) Brian J. Wilson et al.   MOLECULAR ENDOCRINOLOGY

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

The senescence pathway in prostatic carcinogenesis

(2010) Sowmya Sharma et al.   PATHOLOGY

MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

(2010) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX

(2009) Naotoshi Iwahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Establishment of a novel immortalized human prostatic epithelial cell line stably expressing androgen receptor and its application for the functional screening of androgen receptor modulators

(2009) Shan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Neural stem cells in the developing and adult brains

(2009) Qiuhao Qu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of novel ER-α target genes in breast cancer cells: Gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17β-estradiol and tamoxifen

(2009) Andrea Romano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal

(2009) Qiuhao Qu et al.   NATURE CELL BIOLOGY

A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination

(2009) Chunnian Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transrepressive Function of TLX Requires the Histone Demethylase LSD1

(2008) A. Yokoyama et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for adult TLX-positive neural stem cells in learning and behaviour

(2008) Chun-Li Zhang et al.   NATURE

Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer

(2008) Jian Hong Chu et al.   PROSTATE

The orphan nuclear receptor Rev-erbβ recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter

(2007) Jiadong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear Receptor TLX Regulates Cell Cycle Progression in Neural Stem Cells of the Developing Brain

(2007) Wenwu Li et al.   MOLECULAR ENDOCRINOLOGY