Article
Endocrinology & Metabolism
Olivier G. Polle, Antoine Delfosse, Manon Martin, Jacques Louis, Inge Gies, Marieke den Brinker, Nicole Seret, Marie-Christine Lebrethon, Thierry Mouraux, Laurent Gatto, Philippe A. Lysy
Summary: This study evaluated whether indexes of glycemic variability could overcome residual beta-cell secretion estimates in the longitudinal evaluation of partial remission in pediatric patients with new-onset type 1 diabetes. The combination of CGM metrics and clinical parameters revealed key clinical milestones of glucose homeostasis and remission status during the first year of type 1 diabetes in the pediatric cohort.
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raul Navarro-Gil, Albert Feliu, Aida Valls, Antonio Moreno, Marc Baget-Bernaldiz
Summary: Measuring variability in HbA(1c) can help identify patients at risk of developing diabetic retinopathy and microalbuminuria, with coefficient of variation of HbA(1c) as a target for severe DR.
Article
Multidisciplinary Sciences
Ziyang Shen, Hemin Jiang, Rong Huang, Yunting Zhou, Qian Li, Jianhua Ma
Summary: This study found that glycemic variability and hypoglycemia were associated with an increased risk of distal symmetrical polyneuropathy (DSPN) in adults with type 1 diabetes (T1DM), with nocturnal hypoglycemia showing a significant association with DSPN.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Tara T. M. Lee, Corinne Collett, Mei-See Man, Matt Hammond, Lee Shepstone, Sara Hartnell, Eleanor Gurnell, Caroline Byrne, Eleanor M. Scott, Robert S. Lindsay, Damian Morris, Anna Brackenridge, Anna R. Dover, Rebecca M. Reynolds, Katharine F. Hunt, David R. McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Laura E. Bocchino, Judy Sibayan, Craig Kollman, Malgorzata E. Wilinska, Roman Hovorka, Helen R. Murphy
Summary: This study aims to evaluate whether the use of automated closed-loop insulin delivery improves antenatal glucose levels in pregnant women with type 1 diabetes. It will be a multicentre, open label, randomized, controlled trial with 124 participants, analyzing primary and secondary outcomes, as well as safety.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Endocrinology & Metabolism
Soraya Soulimane, Beverley Balkau, Yakima D. Vogtschmidt, Monika Toeller, John H. Fuller, Sabita S. Soedamah-Muthu
Summary: This study aimed to determine whether favorable cardiovascular health metrics or clustering of these metrics can reduce the risk of cardiovascular disease (CVD) in individuals with type 1 diabetes. The results showed that individuals with lower HbA(1c) and blood pressure had significantly lower CVD risk. Furthermore, a greater clustering of favorable metrics was associated with a lower risk of CVD.
Article
Endocrinology & Metabolism
Marzena Gajecka, Pawel Gutaj, Katarzyna Jaskiewicz, Malgorzata Rydzanicz, Tomasz Szczapa, Dorota Kaminska, Grzegorz Kosewski, Juliusz Przyslawski, Rafal Ploski, Ewa Wender-Ozegowska
Summary: This study quantitatively and functionally examined the microbiota in maternal-neonatal dyads from gravidae with type 1 diabetes and explored the impact of pregnancy-specific factors on the microbiomes. It found that type 1 diabetes and certain confounding factors can influence the neonatal microbiomes.
Review
Biochemistry & Molecular Biology
Max L. Eckstein, Felix Aberer, Florian J. R. Dobler, Faisal Aziz, Tim Heise, Harald Sourij, Othmar Moser
Summary: This systematic review and meta-analysis evaluated the association between glycemic control (HbA(1c)) and functional capacity (VO2max) in individuals with type 1 diabetes (T1DM). The results showed a statistically significant negative correlation between HbA(1c) and VO2max, indicating that higher HbA(1c) levels were associated with lower functional capacity. However, the correlation was weak and may not have clinical relevance in individuals with T1DM.
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Brian Kennon, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Rory J. McCrimmon, Graham Leese, Robert S. Lindsay, John Petrie, John Chalmers, Sam Philip, Sarah H. Wild, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: The study aimed to evaluate the use of continuous subcutaneous insulin infusion (CSII) in individuals with type 1 diabetes in Scotland and its impact on glycaemic control. Results showed CSII treatment led to significant reductions in HbA(1c) levels, particularly in those with high baseline levels, and was also associated with lower rates of DKA and SHH events.
Article
Economics
Agnes Benedict, Emily R. Hankosky, Kinga Marczell, Jieling Chen, David J. Klein, J. Jaime Caro, Jay P. Bae, Brian D. Benneyworth
Summary: With the availability of continuous glucose monitoring devices, the ability to track patients' glucose levels over time has changed the landscape of economic models in type 1 diabetes. New measures beyond haemoglobin A1c have been proposed to better define the quality of glycaemic control and reflect the economic value of novel treatments.
Article
Endocrinology & Metabolism
Nina Drojdahl Ryg, Jeppe Gram, Maryam Haghighi, Claus Bogh Juhl
Summary: The study showed that using patient-initiated outpatient visits can increase patient satisfaction with consultations, reduce unnecessary clinic visits, and improve clinic accessibility. Patient needs and satisfaction with the clinic were high and unchanged in both groups, while the use of staff resources decreased due to the intervention.
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Brian Kennon, Rory J. McCrimmon, Graham Leese, Sam Philip, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: Results of the study showed that for type 1 diabetes patients using flash monitors, there was a significant reduction in HbA(1c) levels and a noticeable decrease in DKA rates after FM initiation. The use of FM has important implications for improving blood sugar management in diabetic patients.
Article
Endocrinology & Metabolism
Kendra Vehik, David Boulware, Michael Killian, Marian Rewers, Richard McIndoe, Jorma Toppari, Ake Lernmark, Beena Akolkar, Anette-G. Ziegler, Henry Rodriguez, Desmond A. Schatz, Jeffrey P. Krischer, William Hagopian
Summary: This study suggests that an increase of >= 10% in HbA(1c) from baseline is as informative as OGTT 2-hPG in predicting the risk of stage 3 in children with diabetes-associated autoantibodies.
Article
Endocrinology & Metabolism
Yukari Kobayashi, Jin Long, Shozen Dan, Neil M. Johannsen, Ruth Talamoa, Sonia Raghuram, Sukyung Chung, Kyla Kent, Marina Basina, Cynthia Lamendola, Francois Haddad, Mary B. Leonard, Timothy S. Church, Latha Palaniappan
Summary: This study aimed to investigate the optimal exercise regimen for individuals with "normalweight type 2 diabetes" (BMI < 25 kg/m²). The results showed that strength training alone significantly reduced HbA1c levels and increased lean mass, and strength training was superior to aerobic training alone or combination training.
Article
Endocrinology & Metabolism
Laura M. Jacobsen, Kendra Vehik, Riitta Veijola, Katharina Warncke, Jorma Toppari, Andrea K. Steck, Patricia Gesualdo, Beena Akolkar, Markus Lundgren, William A. Hagopian, Jin-Xiong She, Marian Rewers, Anette-G Ziegler, Jeffrey P. Krischer, Helena Elding Larsson, Michael J. Haller
Summary: The TEDDY study examines age-specific differences associated with type 1 diabetes. Younger children with type 1 diabetes tend to have fewer autoantibodies and more symptoms at diagnosis. The incidence of DKA at onset in TEDDY is rare, especially among individuals with a family history of the disease.
Article
Endocrinology & Metabolism
Sara Hallstrom, Ann-Marie Svensson, Aldina Pivodic, Arndis F. Olafsdottir, Magnus Londahl, Hans Wedel, Marcus Lind
Summary: The incidence of lower extremity amputations in people with type 1 diabetes has decreased over time in Sweden, with major risk factors being hyperglycemia and renal dysfunction.
Article
Endocrinology & Metabolism
Sharon T. Mackin, Scott M. Nelson, Sarah H. Wild, Helen M. Colhoun, Rachael Wood, Robert S. Lindsay, S. Gribble, A. Abubaker, A. Barnett, C. Fischbacher, E. Pearson, G. Leese, J. Chalmers, J. Mcknight, J. Petrie, N. Sattar, O. Wu, R. McCrimmon, S. Philip, S. Cunningham
Article
Medicine, General & Internal
Andreas Ochs, Stuart McGurnaghan, Mike W. Black, Graham P. Leese, Sam Philip, Naveed Sattar, Caroline Styles, Sarah H. Wild, Paul M. McKeigue, Helen M. Colhoun
Article
Endocrinology & Metabolism
Anita Jeyam, Stuart J. McGurnaghan, Luke A. K. Blackbourn, John M. McKnight, Fiona Green, Andrew Collier, Paul M. McKeigue, Helen M. Colhoun
Article
Endocrinology & Metabolism
Joseph E. O'Reilly, Luke A. K. Blackbourn, Thomas M. Caparrotta, Anita Jeyam, Brian Kennon, Graham P. Leese, Robert S. Lindsay, Rory J. McCrimmon, Stuart J. McGurnaghan, Paul M. McKeigue, John A. McKnight, John R. Petrie, Sam Philip, Naveed Sattar, Sarah H. Wild, Helen M. Colhoun
Article
Endocrinology & Metabolism
Thomas M. Caparrotta, Luke A. K. Blackbourn, Stuart J. McGurnaghan, John Chalmers, Robert Lindsay, Rory McCrimmon, John McKnight, Sarah Wild, John R. Petrie, Sam Philip, Paul M. McKeigue, David J. Webb, Naveed Sattar, Helen M. Colhoun
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Brian Kennon, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Rory J. McCrimmon, Graham Leese, Robert S. Lindsay, John Petrie, John Chalmers, Sam Philip, Sarah H. Wild, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: The study aimed to evaluate the use of continuous subcutaneous insulin infusion (CSII) in individuals with type 1 diabetes in Scotland and its impact on glycaemic control. Results showed CSII treatment led to significant reductions in HbA(1c) levels, particularly in those with high baseline levels, and was also associated with lower rates of DKA and SHH events.
Article
Endocrinology & Metabolism
Stuart J. McGurnaghan, Amanda Weir, Jen Bishop, Sharon Kennedy, Luke A. K. Blackbourn, David A. McAllister, Sharon Hutchinson, Thomas M. Caparrotta, Joseph Mellor, Anita Jeyam, Joseph E. O'Reilly, Sarah H. Wild, Sara Hatam, Andreas Hoehn, Marco Colombo, Chris Robertson, Nazir Lone, Janet Murray, Elaine Butterly, John Petrie, Brian Kennon, Rory McCrimmon, Robert Lindsay, Ewan Pearson, Naveed Sattar, John McKnight, Sam Philip, Andrew Collier, Jim McMenamin, Alison Smith-Palmer, David Goldberg, Paul M. McKeigue, Helen M. Colhoun
Summary: The study aimed to compare the risk of fatal or critical care unit-treated COVID-19 between people with and without diabetes, and developed a predictive model. Results showed that people with diabetes had a higher risk of developing the disease, with several related factors, and the predictive model demonstrated good accuracy.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rosemary C. Chamberlain, Kelly Fleetwood, Sarah H. Wild, Helen M. Colhoun, Robert S. Lindsay, John R. Petrie, Rory J. McCrimmon, Fraser Gibb, Sam Philip, Naveed Sattar, Brian Kennon, Graham P. Leese
Summary: This study investigated the incidence of foot ulceration and amputation-free survival in people with diabetes, finding that foot ulceration was associated with lower amputation-free survival rates. Risk factors for foot ulceration in diabetes patients included social deprivation, mental illness, and being underweight.
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Brian Kennon, Rory J. McCrimmon, Graham Leese, Sam Philip, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: Results of the study showed that for type 1 diabetes patients using flash monitors, there was a significant reduction in HbA(1c) levels and a noticeable decrease in DKA rates after FM initiation. The use of FM has important implications for improving blood sugar management in diabetic patients.
Article
Multidisciplinary Sciences
Andreas Hohn, Stuart J. McGurnaghan, Thomas M. Caparrotta, Anita J. Jeyam, Joseph E. O'Reilly, Luke A. K. Blackbourn, Sara J. Hatam, Christian Dudel, Rosie J. R. Seaman, Joseph Mellor, Naveed M. Sattar, Rory J. M. McCrimmon, Brian Kennon, John R. Petrie, Sarah Wild, Paul M. McKeigue, Helen M. Colhoun
Summary: This study examines the impact of socioeconomic disparities on life expectancy and years lived without complications among individuals with type 1 diabetes in Scotland. The results demonstrate that patients with higher levels of socioeconomic deprivation experience shorter life expectancy and fewer years without complications. The study highlights the importance of tailored support for individuals from low socioeconomic backgrounds in diabetes management and complication prevention.
Article
Medicine, General & Internal
Stuart J. McGurnaghan, Luke A. K. Blackbourn, Thomas M. Caparrotta, Joseph Mellor, Anna Barnett, Andy Collier, Naveed Sattar, John McKnight, John Petrie, Sam Philip, Robert Lindsay, Katherine Hughes, David McAllister, Graham P. Leese, Ewan R. Pearson, Sarah Wild, Paul M. McKeigue, Helen M. Colhoun
Summary: The SDRN-National Diabetes Dataset is a research platform that combines electronic health record data for diabetes research in Scotland. It has been used for various studies on disease burden, drug safety, and clinical decision making.
Article
Endocrinology & Metabolism
India Thomson, Niall Anderson, Louise Bath, Sarah Kiff, Chris Patterson, Sam Philip, Norman Waugh, Sarah H. H. Wild
Summary: This study aimed to investigate the incidence of type 1 diabetes in Scotland from 2006 to 2019. Annual cross-sectional studies were conducted using data from SCI-DC. The results showed that the incidence of type 1 diabetes remained stable during the study period and varied by age, sex, and socio-economic status.
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Cathy Shields, Scott G. Cunningham, Deborah J. Wake, Evridiki Fioratou, Doogie Brodie, Sam Philip, Nicholas T. Conway
Summary: This study aims to develop a user-centered digital health intervention tool for predicting diabetes complications risk and providing personalized support. Through methods such as focus groups and user testing, researchers collected and analyzed user opinions and feedback to improve the tool's usability and user engagement. The results indicate that considering user needs and opinions throughout the development process can enhance the effectiveness of the tool and have a positive impact on users' self-management and health outcomes.
JMIR HUMAN FACTORS
(2022)
Meeting Abstract
Endocrinology & Metabolism
A. Gautam, S. Philip, M. J. MacLeod, A. Cadzow, A. J. Graveling