期刊
DIABETES-METABOLISM RESEARCH AND REVIEWS
卷 31, 期 2, 页码 175-182出版社
WILEY
DOI: 10.1002/dmrr.2583
关键词
type 1 diabetes mellitus; neuropathy; neuroprotective; CSII; MDI; insulin
资金
- National Health and Medical Research Council of Australia (NHMRC) [104692]
- Australian Postgraduate Award scholarship
- Career Development Award of the National Health and Medical Research Council of Australia [568680]
BackgroundDiabetic peripheral neuropathy is a common and debilitating complication of diabetes mellitus. Although strict glycaemic control may reduce the risk of developing diabetic peripheral neuropathy, the neurological benefits of different insulin regimens remain relatively unknown. MethodsIn the present study, 55 consecutive patients with type 1 diabetes mellitus underwent clinical neurological assessment. Subsequently, 41 non-neuropathic patients, 24 of whom were receiving multiple daily insulin injections (MDII) and 17 receiving continuous subcutaneous insulin infusion (CSII), underwent nerve excitability testing, a technique that assesses axonal ion channel function and membrane potential in human nerves. Treatment groups were matched for glycaemic control, body mass index, disease duration and gender. Neurophysiological parameters were compared between treatment groups and those taken from age and sex-matched normal controls. ResultsProminent differences in axonal function were noted between MDII-treated and CSII-treated patients. Specifically, MDII patients manifested prominent abnormalities when compared with normal controls in threshold electrotonus (TE) parameters including depolarizing TE(10-20ms), undershoot and hyperpolarizing TE (90-100ms) (P<0.05). Additionally, recovery cycle parameters superexcitability and subexcitability were also abnormal (P<0.05). In contrast, axonal function in CSII-treated patients was within normal limits when compared with age-matched controls. The differences between the groups were noted in cross-sectional analysis and remained at longitudinal follow-up. ConclusionsAxonal function in type 1 diabetes is maintained within normal limits in patients treated with continuous subcutaneous insulin infusion and not with multiple daily insulin injections. This raises the possibility that CSII therapy may have neuroprotective potential in patients with type 1 diabetes. Copyright (c) 2014 John Wiley & Sons, Ltd.
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