Review
Endocrinology & Metabolism
Alexia Carre, Federica Vecchio, Malin Flodstrom-Tullberg, Sylvaine You, Roberto Mallone
Summary: The evidence for an association between CVB infection and type 1 diabetes is growing, although a causal relationship has not yet been proven. CVB vaccines have been developed to avoid exposure and are currently in clinical trials. Understanding the immune responses triggered by CVB infection is crucial for maximizing vaccination success and monitoring its interaction with autoimmune onset or prevention.
Article
Endocrinology & Metabolism
Huan Liu, Shirin Geravandi, Ausilia Maria Grasso, Saheri Sikdar, Alberto Pugliese, Kathrin Maedler
Summary: This study found no association between enteroviral infection in the pancreas and T2D diabetes. Despite similarities in inflammatory markers in islets in both T1D and T2D, long-term enteroviral infiltration is a distinct pathological feature of T1D-associated autoimmunity and T1D pancreases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Microbiology
Sonia R. Isaacs, Dylan B. Foskett, Anna J. Maxwell, Emily J. Ward, Clare L. Faulkner, Jessica Y. X. Luo, William D. Rawlinson, Maria E. Craig, Ki Wook Kim
Summary: This article provides an overview of the role of viruses in the development of type 1 diabetes and discusses concerns over bias towards enteroviruses in research. It also highlights current unbiased efforts in characterizing the virome contributing to early development of islet autoimmunity and type 1 diabetes. Additionally, it reviews the candidates of vaccines and antiviral drugs currently being evaluated for the prevention and treatment of type 1 diabetes.
Review
Endocrinology & Metabolism
Magloire Pandoua Nekoua, Enagnon Kazali Alidjinou, Didier Hober
Summary: This review highlights the role of persistent enterovirus infections in triggering islet autoimmunity and type 1 diabetes mellitus (T1DM), and discusses the potential of vaccination or antiviral therapies in preventing T1DM onset.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Review
Microbiology
Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Helene Michaux, Famara Sane, Aymen Halouani, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Martens, Hela Jaidane, Vincent Geenen, Didier Hober
Summary: Viral infections, especially CVB4 infection, can disrupt thymic functions and may play a role in the pathogenesis of type 1 diabetes (T1D) by affecting thymic cells and functions.
Review
Immunology
Zachary J. Morse, Marc S. Horwitz
Summary: Environmental factors and genetic predisposition contribute to the development of T1D, with the gut playing a key role in immune modulation and microbiome changes potentially serving as a biomarker for autoimmune responses and diabetes development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Erika Jimbo, Tetsuro Kobayashi, Akira Takeshita, Keiichiro Mine, Seiho Nagafuchi, Tomoyasu Fukui, Soroku Yagihashi
Summary: This study introduces a new polyclonal antiserum against CVB1-2A(pro), which may be beneficial for immunohistochemistry of EV-infected human tissues stored as formaldehyde-fixed and paraffin-embedded tissue samples.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Fuxing Lou, Ruolan Hu, Yangzhen Chen, Mengzhe Li, Xiaoping An, Lihua Song, Yigang Tong, Huahao Fan
Summary: This study investigates the inhibitory effect of 16 major human milk components on coxsackievirus. The results show that 2'-Fucosyllactose (2'-FL) effectively blocks virus entry and attachment, reducing infection. Molecular docking analysis reveals 2'-FL's specific cellular targets. These findings lay the foundation for using 2'-FL as a food additive against coxsackievirus infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lars Krogvold, Ida Maria Mynarek, Erica Ponzi, Freja Barrett Mork, Trine Witzner Hessel, Trine Roald, Nina Lindblom, Jacob Westman, Peter Barker, Heikki Hyoety, Johnny Ludvigsson, Kristian F. Hanssen, Jesper Johannesen, Knut Dahl-Jorgensen
Summary: The results suggest that antiviral treatment may help preserve insulin production in children and adolescents with new-onset type 1 diabetes.
Article
Public, Environmental & Occupational Health
Li Ding, Ning Zhang, Bin Zhu, Jinlin Liu, Xue Wang, Feng Liu, Ying Mao
Summary: HFMD is a common intestinal infectious disease globally, with distinct regional differences in incidence rates within Shaanxi Province. High-incidence areas are mainly located in the central region, and the incidence rate of HFMD is positively associated with meteorological factors such as rainfall, temperature, and humidity.
Article
Cell Biology
Yasir Mohamud, Hui Tang, Yuan Chao Xue, Huitao Liu, Chen Seng Ng, Amirhossein Bahreyni, Honglin Luo
Summary: Coxsackievirus B3 targets TFEB for proteolytic processing to disrupt host lysosomal function and enhance viral infection.
Review
Virology
Magloire Pandoua Nekoua, Ambroise Mercier, Ines Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Delphine Lobert, Ilka Engelmann, Marie-Benedicte Romond, Enagnon Kazali Alidjinou, Didier Hober
Summary: Epidemiological and experimental studies suggest that enteroviruses, particularly coxsackieviruses B, may trigger or accelerate the onset of islet autoimmunity and the development of type 1 diabetes in genetically susceptible individuals. Several potential mechanisms have been proposed to explain the involvement of coxsackieviruses B in the pathogenesis of type 1 diabetes, including persistent infection in various cells and the resulting chronic inflammatory response and disruption of tolerance towards ss-cells. Vaccine or therapeutic strategies to control enterovirus infections show potential for the prevention or treatment of type 1 diabetes.
Article
Virology
Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Amirhossein Bahreyni, Honglin Luo, Yasir Mohamud
Summary: This study investigated how enteroviruses utilize the cellular autophagy pathway for replication. The authors discovered that Coxsackievirus B3 (CVB3) selectively degrades the autophagy cysteine protease ATG4A and identified the site at which CVB3 protease 2A cleaves ATG4A. Furthermore, cleavage of ATG4A was found to result in a loss of autophagy function.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Virology
Raiana S. Machado, Francisco Gomes-Neto, Maria L. Aguiar-Oliveira, Fernanda M. Burlandy, Fernando N. Tavares, Edson E. da Silva, Ivanildo P. Sousa Jr
Summary: This study investigated the viral genetic diversity, molecular, and epidemiological aspects of CVB5 in Brazil, revealing the circulation of two CVB5 genogroups and important amino acid substitutions in residues known for their critical roles in viral host tropism.
Article
Virology
S. Smithee, S. Tracy, N. M. Chapman
JOURNAL OF VIROLOGY
(2015)
Article
Virology
Catherine H. Schein, Mengyi Ye, Aniko V. Paul, M. Steven Oberste, Nora Chapman, Gerbrand J. van der Heden van Noort, Dmitri V. Filippov, Kyung H. Choi
Article
Biotechnology & Applied Microbiology
Steven D. Carson, Steven Tracy, Zac G. Kaczmarek, Abdulaziz Alhazmi, Nora M. Chapman
JOURNAL OF GENERAL VIROLOGY
(2016)
Article
Virology
L. Jaramillo, S. Smithee, S. Tracy, N. M. Chapman
Article
Virology
Shane Smithee, Steven Tracy, Nora M. Chapman
Editorial Material
Immunology
Nora M. Chapman
Correction
Biotechnology & Applied Microbiology
Steven D. Carson, Steven Tracy, Zac G. Kaczmarek, Abdulaziz Alhazmi, Nora M. Chapman
JOURNAL OF GENERAL VIROLOGY
(2017)
Article
Virology
Steven Tracy, Shane Smithee, Abdulaziz Alhazmi, Nora Chapman
JOURNAL OF MEDICAL VIROLOGY
(2015)
Article
Microbiology
John C. Mullican, Nora M. Chapman, Steven Tracy
Article
Multidisciplinary Sciences
Xiang Liu, Dahn L. Clemens, James A. Grunkemeyer, Jeffrey D. Price, Kelly O'Connell, Nora M. Chapman, Peter Storz, Haitao Wen, Jesse L. Cox, Whitney L. Reid, Michael A. Hollingsworth, Sarah Thayer
SCIENTIFIC REPORTS
(2019)
Review
Immunology
Nora M. Chapman
Summary: Enteroviruses have been found to persist in cell cultures and in vivo through a novel mechanism involving the deletion of a part of the genome, resulting in mutant populations. Studies have shown significant differences between these mutant populations, termed TD enteroviruses, and canonical enteroviruses, with the TD enteroviruses becoming dominant in quiescent cell populations.
Editorial Material
Microbiology
Brian T. Nguyen, Nora M. Chapman, Holly A. F. Stessman, Steven Tracy, Kristen M. Drescher
Summary: Amoebae of the Naegleria genus carry all ribosome-encoding DNA on closed circular extrachromosomal elements (CERE). We report the sequence of the CERE of Naegleria jadini (strain Willaert and Ray).
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Brian T. Nguyen, Nora M. Chapman, Niklas Johnson, Holly A. F. Stessman, Steven Tracy, Kristen M. Drescher
Summary: In this report, the sequence of the extrachromosomal ribosomal DNA-containing elements (CERE) of Naegleria australiensis De Jonckheere (strain PP397) is described, revealing the unique feature of ribosomal RNA encoding on circular DNA elements in this amoebae genus.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
John C. Mullican, Kristen M. Drescher, Nora M. Chapman, Steven Tracy
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
John C. Mullican, Nora M. Chapman, Steven Tracy
GENOME ANNOUNCEMENTS
(2018)