Article
Medical Laboratory Technology
Guido Freckmann, James H. Nichols, Rolf Hinzmann, David C. Klonoff, Yi Ju, Peter Diem, Konstantinos Makris, Robbert J. Slingerland
Summary: People with diabetes need to monitor their glucose levels regularly, and traditional self-monitoring systems are being replaced by minimally invasive continuous glucose monitoring systems. However, these CGM systems face challenges with accuracy and lack of international reference measurement procedures.
CLINICA CHIMICA ACTA
(2021)
Article
Biophysics
Xiaofeng Jin, Guanhua Li, Tailin Xu, Lei Su, Dan Yan, Xueji Zhang
Summary: Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Multidisciplinary
Yilin Li, Yueyue Chen
Summary: This paper reviews the research progress of noninvasive continuous blood glucose monitoring (CGM), focusing on the replacement of biological liquids for blood in monitoring systems, the technical principles of continuous noninvasive glucose detection, and the output and calibration of sensor signals. Additionally, the existing limitations and future prospects of noninvasive CGM systems are discussed.
Article
Multidisciplinary Sciences
Valentina Vitale, Lise C. Berg, Bettina Birch Larsen, Andrea Hannesdottir, Preben Dybdahl Thomsen, Sigrid Hyldahl Laursen, Denis Verwilghen, Gaby van Galen
Summary: This study investigates the feasibility of using a continuous glucose monitoring system in critically ill adult horses and foals, finding that the system can accurately monitor glucose levels. However, there are challenges such as lag time in interstitial glucose levels and fluctuations that do not always correspond to blood glucose levels that need to be addressed for wider usability of the system.
Article
Pediatrics
Mohammed Abdul Wasiq, Sushree Smita Behura, Swaranjika Sahoo, Santosh Kumar Panda
Summary: The study aimed to assess the accuracy and reliability of continuous glucose monitoring (CGM) device in detecting hyperglycaemia during the postoperative period in neonates. Hourly glucose recordings by CGM device and six hourly glucometer glucose measurements were collected in ten surgical neonates. The results showed that CGM device had a sensitivity of 100%, specificity of 93.9%, positive predictive value of 88%, and negative predictive value of 100% for detecting hyperglycaemia. Clarke Error Grid Analysis also demonstrated a high degree of accuracy during the hyperglycaemia period. Conclusion: CGM device is a clinically reliable tool for managing hyperglycaemia in neonates during the postoperative period.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Chemistry, Analytical
Marsilea A. Booth, Sally A. N. Gowers, Melinda Hersey, Isabelle C. Samper, Seongjun Park, Polina Anikeeva, Parastoo Hashemi, Molly M. Stevens, Martyn G. Boutelle
Summary: The study explored the potential of polymer fibers as a platform for sensing pH and neurometabolic lactate, successfully detecting transient lactate changes in an in vivo mouse model. The changes in lactate concentration were associated with spreading depolarizations.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Md Abu Zahed, Dong Kyun Kim, Seong Hoon Jeong, Md Selim Reza, Md Sharifuzzaman, Gagan Bahadur Pradhan, Hyesu Song, Md Asaduzzaman, Jae Yeong Park
Summary: In this study, a flexible patch-based wireless system integrating multimodal biosensing and microfluidic channels is developed for real-time and continuous monitoring. The system accurately monitors sweat glucose and electrocardiogram (ECG) during physical exercise. The sensors show good sensitivity and stability, and the electrodes exhibit high-quality electrophysiological signals.
Article
Chemistry, Analytical
Ming-Nan Chien, Yu-Jen Chen, Chin-Han Bai, Jung-Tung Huang
Summary: In this research, a continuous blood glucose monitoring system (CGMS) is developed, which includes a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device. The system enables continuous blood glucose sensing and wireless data transmission. Through various experiments and analyses, the feasibility and effectiveness of the system are demonstrated.
Article
Endocrinology & Metabolism
Michael A. Rotondi, Octavia Wong, Michael Riddell, Bruce Perkins
Summary: Universal use of CGM or isCGM in the Canadian T1D population is expected to reduce diabetes-related complications and mortality at an acceptable cost-effectiveness threshold.
Article
Biophysics
Inyoung Lee, David Probst, David Klonoff, Koji Sode
Summary: Diabetes mellitus is a chronic illness in the United States with approximately 120 million affected adults. Tight glycemic control is essential for managing diabetes and reducing the risk of complications. Continuous glucose monitoring systems are recognized as the ideal monitoring systems for diabetic patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Materials Science, Multidisciplinary
Nan Jiang, Sergey Flyax, Wolfgang Kurz, Martin Jakobi, Savas Tasoglu, Alexander W. Koch, Ali K. Yetisen
Summary: Monitoring physiological parameters in the brain is crucial for early detection of secondary brain injuries, with a variety of intracranial sensors allowing continuous monitoring in clinical applications. Fiber-optic sensors show potential for future intracranial applications.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Biochemistry & Molecular Biology
Emily K. Gifford, Elaine M. Robbins, Andrea Jaquins-Gerstl, Michael T. Rerick, Enyinna L. Nwachuku, Stephen G. Weber, Martyn G. Boutelle, David O. Okonkwo, Ava M. Puccio, Adrian C. Michael
Summary: Monitoring brain metabolism with intracranial microdialysis can provide important clinical insights for limiting secondary injury after traumatic brain injury. The use of dexamethasone-enhanced microdialysis has been shown to be effective in long-term monitoring of brain glucose levels after injury, linking intracranial glucose microdialysis to glucose utilization in surrounding tissues and implicating aberrant glucose utilization as a driver of postinjury glucose decline.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Yiqun Liu, Qi Yu, Xiaojin Luo, Li Yang, Yue Cui
Summary: The study demonstrated the continuous monitoring of diabetes using an integrated microneedle biosensing device, which showed accurate sensing performance by inserting into the dermis layer of mouse skin and yielded detection results highly correlated with those from a commercial blood glucose meter.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Engineering, Biomedical
Diana G. Kulawiec, Tony Zhou, Jennifer L. Knopp, J. Geoffrey Chase
Summary: The study reveals that glycemic variability and glycemic response to carbohydrate intake of athletes increase after endurance exercise, while overnight glucose levels remain elevated. These metabolic effects can be quantified using commercially available CGM devices, encouraging further research on monitoring athletic recovery after intense exercise events.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Chemistry, Multidisciplinary
Jin Li, Diane J. Burgess
Summary: This study focuses on improving diabetes management by monitoring stress biomarkers, revealing that pH, lactate, and glucose levels changed more significantly under stress conditions, with long-acting insulin treatment shown to shorten these changes. Subcutaneous pH was identified as a sensitive stress biomarker for diabetic rats, emphasizing the importance of accurate glycemic control and the potential for personalized medicine through appropriate biomarker monitoring.
JOURNAL OF CONTROLLED RELEASE
(2021)