Article
Chemistry, Analytical
Sissel Banner Lundemose, Christian Laugesen, Ajenthen Gayathri Ranjan, Kirsten Norgaard
Summary: This study assessed the accuracy of three latest factory-calibrated CGM systems in both aerobic exercise and daily life scenarios. The results showed that Dexcom G6 and Guardian 4 demonstrated superior accuracy compared to Freestyle Libre 2 in both exercise and daily life situations.
Review
Chemistry, Analytical
Elena Munoz Fabra, Jose-Luis Diez, Jorge Bondia, Alejandro Jose Laguna Sanz
Summary: CGM monitoring during exercise periods is less accurate and can impact CGM-based treatments for diabetes patients. Most papers did not provide accuracy metrics that differentiated between exercise and rest (non-exercise) periods, hindering comparative data analysis.
News Item
Medicine, General & Internal
Mary Chris Jaklevic
Summary: The story provides guidelines for people with type 1 diabetes on how to respond to readings on glucose monitors before, during, and after exercise.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Lalantha Leelarathna, Mark L. L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. J. Sutton, Rachel A. A. Elliott, Vicky P. P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. G. Wilmot
Summary: This study investigated the efficacy of intermittently scanned continuous glucose monitoring in patients with type 1 diabetes. The results showed that compared to traditional fingerstick testing, the use of intermittently scanned continuous glucose monitoring significantly reduced glycated hemoglobin levels and improved blood glucose control.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block
Summary: The study found that diabetes knowledge and health literacy impact glycemic control, with higher diabetes knowledge and health literacy scores associated with improved glycemic control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Zifan Wang, Tamarra M. James-Todd, Elvira Isganaitis, Julianne O'Connell, Sarit Helman, Jennifer A. Wyckoff, Shanti Serdy, Elizabeth Halprin, Karen O'Brien, Munish Gupta, Florence M. Brown
Summary: The study suggests that the use of insulin pump or CGM during pregnancy in women with type 1 diabetes can improve glycemic control, but pump use may be associated with higher birth weight measures.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Endocrinology & Metabolism
Tomasz Klupa, Leszek Czupryniak, Grzegorz Dzida, Piotr Fichna, Przemyslawa Jarosz-Chobot, Janusz Gumprecht, Malgorzata Mysliwiec, Agnieszka Szadkowska, Dorota Bomba-Opon, Krzysztof Czajkowski, Maciej T. Malecki, Dorota A. Zozulinska-Ziolkiewicz
Summary: The application of continuous glucose monitoring (CGM) has revolutionized diabetes care by shifting from a reactive to proactive approach. CGM devices are now considered the gold standard for people with type 1 diabetes and evidence supports their use in type 2 diabetes as well. Expanding the use of CGM can lead to improved therapy, reduced complications, and lowered healthcare costs, all while enhancing quality of life for individuals with diabetes. Additionally, CGM can provide benefits for pregnant women with diabetes, non-diabetic individuals with glycemic dysregulation, and hospital inpatients.
Article
Chemistry, Physical
Jiyong Kim, Salman Khan, Eun Kyu Kim, Hye-Jun Kil, Bo Min Kang, Hyo Geon Lee, Jin-Woo Park, Jun Young Yoon, Woochul Kim
Summary: Continuous monitoring and timely treatment are crucial for wearable and implantable healthcare systems, but they require continuous power supply. We developed a continuous healthcare system for type 1 diabetes by combining a low-energy micropump, self-powered glucose sensor, and body heat conversion to electricity. This system can provide true continuous healthcare for patients.
Article
Medicine, General & Internal
Courtney R. Chang, Brooke M. Russell, Tannia Cyriac, Monique E. Francois
Summary: This study investigates the feasibility of using continuous glucose monitoring (CGM) to prescribe an individualized daily exercise time for people with type 2 diabetes. The results show that prescribing exercise time based on CGM data can increase patients' participation in physical activity, but more research is needed to test its long-term impact.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Diana Tundidor, Claire L. Meek, Jennifer Yamamoto, Cecilia Martinez-Bru, Ignasi Gich, Denice S. Feig, Helen R. Murphy, Rosa Corcoy
Summary: The CONCEPTT trial found that pregnant women with type 1 diabetes had low rates of CGM and HbA(1c) target attainment, but these rates increased with RT-CGM use and throughout gestation. However, achieving the TBR target was associated with increased risk of pre-eclampsia and neonatal hypoglycemia, indicating the need for further study. Achievement of ADA HbA(1c) target was independently associated with better perinatal outcomes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Anna McLean, Elizabeth Barr, Georgina Tabuai, Helen R. Murphy, Louise Maple-Brown
Summary: This study aimed to describe glucose metrics in a high-risk population of women with type 2 diabetes (T2DM) in pregnancy and explore their associations with neonatal outcomes. The results showed that CGM metrics only improved during pregnancy in women with greater sensor use and were associated with large for gestational age (LGA) in early pregnancy and neonatal hypoglycemia. Culturally appropriate health care strategies are critical for successful use of CGM technology.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Ping Ling, Daizhi Yang, Chaofan Wang, Xueying Zheng, Sihui Luo, Xubin Yang, Hongrong Deng, Wen Xu, Jinhua Yan, Jianping Weng
Summary: This study aimed to derive a best-fitting model to calculate glucose management indicator (GMI) from mean blood glucose (MBG) obtained from continuous glucose monitoring (CGM) among pregnant women with type 1 diabetes mellitus (T1DM). After analyzing the CGM data and HbA1c levels of 98 pregnant women with T1DM, a pregnancy-specific GMI-MBG equation was developed. This equation should be recommended for antenatal clinical care.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Othmar Moser, Christoph Sternad, Max L. Eckstein, Agnieszka Szadkowska, Arkadiusz Michalak, Julia K. Mader, Haris Ziko, Hesham Elsayed, Felix Aberer, Agnes Sola-Gazagnes, Etienne Larger, Gian Poalo Fadini, Benedetta Maria Bonora, Daniela Bruttomesso, Federico Boscari, Guido Freckmann, Stefan Pleus, Sverre C. Christiansen, Harald Sourij
Summary: The pooled analysis showed that isCGM performed well in children, adolescents, and adults with type 1 diabetes, exhibiting higher accuracy compared to reference blood glucose measurements. However, the rate of change in glucose levels, both increasing and decreasing, decreased the performance of isCGM.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Kartik K. Venkatesh, Camille E. Powe, Elizabeth Buschur, Jiqiang Wu, Mark B. Landon, Steven Gabbe, Kajal Gandhi, William A. Grobman, Naleef Fareed
Summary: We studied the characteristics of CGM use in women of reproductive age with T1D. The frequency of CGM increased from 2015 to 2018 and was more common among women who recently had a pregnancy. Factors associated with lower odds of CGM use included race/ethnicity, age, education, income, and insurance type. CGM use was linked to better glycemic control but was not associated with a difference in the odds of severe hypoglycemia.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Engineering, Chemical
Paolo Trucillo
Summary: This paper is a description of a diabetic patient's experience with the treatment of diabetes using a multi-injection insulin system and an automated insulin administration system. The author compares the advantages and disadvantages of both systems and highlights the importance of educating patients to approach illness treatment in a scientific manner.
Review
Endocrinology & Metabolism
Moshe Phillip, Revital Nimri, Richard M. Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P. Kovatchev, Laurel H. Messer, Christopher G. Parkin, Louise Ambler-Osborn, Stephanie A. Amiel, Lia Bally, Roy W. Beck, Sarah Biester, Torben Biester, Julia E. Blanchette, Emanuele Bosi, Charlotte K. Boughton, Marc D. Breton, Sue A. Brown, Bruce A. Buckingham, Albert Cai, Anders L. Carlson, Jessica R. Castle, Pratik Choudhary, Kelly L. Close, Claudio Cobelli, Amy B. Criego, Elizabeth Davis, Carine de Beaufort, Martin de Bock, Daniel J. DeSalvo, J. Hans DeVries, Klemen Dovc, Francis J. Doyle, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P. Forlenza, Geraldine Gallen, Satish K. Garg, Dana C. Gershenoff, Linda A. Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B. Hirsch, Korey K. Hood, Diana Isaacs, David C. Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A. Lal, Lalantha Leelarathna, David M. Maahs, Helen R. Murphy, Kirsten Norgaard, David O'Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C. Riddell, David Rodbard, Steven J. Russell, Desmond A. Schatz, Viral N. Shah, Jennifer L. Sherr, Gregg D. Simonson, R. Paul Wadwa, Candice Ward, Stuart A. Weinzimer, Emma G. Wilmot, Tadej Battelino
Summary: The global prevalence of diabetes continues to be a challenge and the advances in automated insulin delivery (AID) technologies have shown to be safe and effective in helping patients achieve their glycemic goals. However, there is a lack of guidance for clinicians on using AID systems in clinical settings.
Article
Endocrinology & Metabolism
Hood Thabit, Womba Mubita, Jose Rubio, Mini Karuppan, Jonathan Schofield, Malgorzata E. Willinska, Roman Hovorka, Lalantha Leelarathna
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Alice M. Gregory, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Gabija Krutkyte, Jonathan Roos, Daniel Schuerch, Cecilia Czerlau, Malgorzata E. Wilinska, Patrick Y. Wuethrich, David Herzig, Roman Hovorka, Andreas P. Vogt, Beat Gloor, Lia Bally
Summary: This study evaluated the perioperative glucose management in patients undergoing pancreatic surgery. The use of the fully closed-loop insulin therapy resulted in better glucose control without increasing the risk of hypoglycemia.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
David Rankin, Ruth I. Hart, Barbara Kimbell, Katharine Barnard-Kelly, Anna Brackenridge, Caroline Byrne, Corinne Collett, Anna R. Dover, Sara Hartnell, Katharine F. Hunt, Tara T. M. Lee, Robert S. Lindsay, David R. McCance, Alastair McKelvey, Gerry Rayman, Rebecca M. Reynolds, Eleanor M. Scott, Sara L. White, Roman Hovorka, Helen R. Murphy, Julia Lawton, iDAPT Collaborative Grp
Summary: This study aimed to explore healthcare professionals' views on the training and support needed to roll out closed-loop technology to pregnant women with type 1 diabetes. Interviews with 19 healthcare professionals were conducted, and an online workshop involving 15 trial team members was used to gather recommendations. The results revealed that healthcare professionals were optimistic about a national rollout of closed-loop, but they also anticipated various challenges.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Julia Ware, Janet M. Allen, Charlotte K. Boughton, Alina Cezar, Sara Hartnell, Malgorzata E. Wilinska, Ajay Thankamony, Mark Deakin, Hannah Leyland, Karen Phelan, Keith Thornborough, Roman Hovorka
Summary: This study evaluated the use of hybrid closed-loop (HCL) insulin delivery with faster insulin aspart (Fiasp) in very young children with type 1 diabetes (T1D). The results showed that there was no significant difference in glycemic control between HCL with Fiasp and standard insulin aspart (IAsp) in children aged 2-6 years with T1D.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Letter
Endocrinology & Metabolism
Rama Lakshman, Aideen B. Daly, Munachiso Nwokolo, Sara Hartnell, Malgorzata E. Wilinska, Alina Cezar, Mark L. Evans, Roman Hovorka, Charlotte K. Boughton
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Heba Alwan, Julia Ware, Charlotte E. Boughton, Malgorzata M. Wilinska, Janet Allen, Rama Lakshman, Munachiso Nwokolo, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Nikki Davis, Louise Denvir, Mark L. Evans, Elke Froehlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Parth Narendran, Birgit Rami-Mehrar, Martin Tauschmann, Hood Thabit, Ajay Thankamony, Roman Hovorka
Summary: This study aimed to assess the difference in percentage of time spent in hypoglycemia during closed-loop insulin delivery among different age groups and time of day. The results showed that the median time spent in hypoglycemia over the 24-hour period was highest in children and adolescents, followed by very young children, adults, and older adults. Time spent in hypoglycemia during nighttime was lower than during daytime across all age groups.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Charlotte K. Boughton, Sara Hartnell, Nicola Hobday, Andrea Lake, Katy Davenport, Aideen Daly, Candice Ward, Caroline Taylor, Roman Hovorka, Vishakha Bansiya
Summary: The study investigated the feasibility of implementing a fully closed-loop insulin delivery system in a hospital setting and found that it can be safely and effectively implemented in complex medical and surgical inpatients with challenging glycaemic control.
Article
Endocrinology & Metabolism
Julia Lawton, David Rankin, Sara Hartnell, Tara Lee, Anna R. Dover, Rebecca M. Reynolds, Roman Hovorka, Helen R. Murphy, Ruth I. Hart, AiDAPT Collaborative Grp
Summary: This study explored the benefits of using the CamAPS FX system during the AiDAPT trial for pregnant women with type 1 diabetes. Healthcare professionals highlighted the clinical and quality-of-life benefits, but emphasized the importance of effective collaboration between healthcare professionals, pregnant women, and the closed-loop system. They recommended offering closed-loop systems to all pregnant women with type 1 diabetes in the future.
Article
Endocrinology & Metabolism
Juan J. Madrid-Valero, Julia Ware, Janet M. Allen, Charlotte K. Boughton, Sara Hartnell, Malgorzata E. Wilinska, Ajay Thankamony, Carine de Beaufort, Ulrike Schierloh, Fiona M. Campbell, Judy Sibayan, Laura E. Bocchino, Craig Kollman, Roman Hovorka, Alice M. Gregory, KidsAP Consortium
Summary: This study compared sleep quality and quantity in caregivers of children using a closed-loop system (CL) or sensor-augmented pump (SAP) therapy. The results showed that parents in the CL group reported shorter sleep duration but better sleep quality, fewer awakenings, and less wake after sleep onset compared to the SAP group.
PEDIATRIC DIABETES
(2023)
Article
Medicine, General & Internal
Benjamin Davies, Oliver D. Mowforth, Stefan Yordanov, Daniel Alvarez-Berdugo, Simon Bond, Marianna Nodale, Paula Kareclas, Lynne Whitehead, Jon Bishop, Siddharthan Chandran, Sarah Lamb, Mark Bacon, Marios C. Papadopoulos, Michelle Starkey, Iwan Sadler, Lara Smith, Sukhvinder Kalsi-Ryan, Adrian Carpenter, Rikin A. Trivedi, Martin Wilby, David Choi, Ian B. Wilkinson, Michael G. Fehlings, Peter John Hutchinson, Mark R. N. Kotter
Summary: This study aims to test the disease-modulating activity of the phosphodiesterase 3/phosphodiesterase 4 inhibitor Ibudilast as an adjuvant to surgical decompression in Degenerative cervical myelopathy (DCM). It is a multicentre, double-blind, randomised, placebo-controlled trial. The primary endpoints are pain and physical function measured at 6 months after surgery.
Letter
Endocrinology & Metabolism
Atrayee K. Ghatak, Charlotte M. Boughton, Janet Allen, Julia E. Ware, Malgorzata Wilinska, Sara Hartnell, Ajay Thankamony, Tabitha Randell, Rachel E. J. Besser, Daniela Elleri, Nicola M. Trevelyan, Fiona Campbell, Roman Hovorka, CLOuD Consortium
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Heba Alwan, Malgorzata E. Wilinska, Yue Ruan, Julien Da Silva, Roman Hovorka
Summary: We analyzed real-world evidence to assess the performance of the mylife CamAPS FX hybrid closed-loop system. Users from 15 countries across different age groups who used the system between May 9, 2022, and December 3, 2022, were included in the analysis (N = 1805). The results showed that glycemic outcomes from this real-world evidence are comparable to previous randomized controlled studies, confirming the efficacy of this hybrid closed-loop system in real-world settings.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Rheumatology
Rona M. Smith, Rachel B. Jones, Ulrich Specks, Simon Bond, Marianna Nodale, Reem Al-jayyousi, Jacqueline Andrews, Annette Bruchfeld, Brian Camilleri, Simon Carette, Chee Kay Cheung, Vimal Derebail, Tim Doulton, Alastair Ferraro, Lindsy Forbess, Shouichi Fujimoto, Shunsuke Furuta, Ora Gewurz-Singer, Lorraine Harper, Toshiko Ito-Ihara, Nader Khalidi, Rainer Klocke, Curry Koening, Yoshinori Komagata, Carol Langford, Peter Lanyon, Raashid Luqmani, Carol McAlear, Larry W. Moreland, Kim Mynard, Patrick Nachman, Christian Pagnoux, Chen Au Peh, Charles Pusey, Dwarakanathan Ranganathan, Rennie L. Rhee, Robert Spiera, Antoine G. Sreih, Vladamir Tesar, Giles Walters, Caroline Wroe, David Jayne, Peter A. Merkel
Summary: Following remission induction with rituximab, repeat-dose rituximab was superior to azathioprine for preventing disease relapse in patients with AAV with a prior history of relapse.
ANNALS OF THE RHEUMATIC DISEASES
(2023)