Article
Immunology
Clare Eckold, Vinod Kumar, January Weiner, Bachti Alisjahbana, Anca-Lelia Riza, Katharina Ronacher, Jorge Coronel, Sarah Kerry-Barnard, Stephanus T. Malherbe, Leanie Kleynhans, Kim Stanley, Rovina Ruslami, Mihai Ioana, Cesar Ugarte-Gil, Gerhard Walzl, Reinout van Crevel, Cisca Wijmenga, Julia A. Critchley, Hazel M. Dockrell, Jacqueline M. Cliff
Summary: Individuals with both tuberculosis (TB) and diabetes show altered blood transcriptomes, with enhanced inflammation and reduced type I interferon responses. Interestingly, patients with intermediate hyperglycemia (IH) and TB exhibit similar blood transcriptomes to those with diabetes-TB comorbidity, indicating potential immunological dysfunctions in individuals with IH that may affect TB outcomes. Further investigation is needed for individuals with IH diagnosed with TB.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Microbiology
Minh Dao Ngo, Stacey Bartlett, Katharina Ronacher
Summary: Diabetes is a major risk factor for tuberculosis, making patients more susceptible to developing active pulmonary TB. The relative contribution of different metabolic factors to increased susceptibility to TB is still not well understood.
Review
Immunology
Phillip Ssekamatte, Obondo James Sande, Reinout van Crevel, Irene Andia Biraro
Summary: Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance. The review discusses the epidemiological aspects of DM and TB, and explores the mechanisms of susceptibility to TB in T2DM patients. Understanding these mechanisms can help develop practical treatment plans to lessen the burden of the diseases in rampant areas.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kevin Flores-Lovon, Brando Ortiz-Saavedra, Luis A. Cueva-Chicana, Shalom Aperrigue-Lira, Elizbet S. Montes-Madariaga, David R. Soriano-Moreno, Brett Bell, Rodney Macedo
Summary: Patients with COVID-19 and tuberculosis coinfection show varying immune responses. Patients with asymptomatic COVID-19 and latent tuberculosis exhibit enhanced immune response, while those with COVID-19 and active tuberculosis display dysregulated immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Arshad Javed Shaikh, Gaurav Gupta, Obaid Afzal, Madan Mohan Gupta, Ahsas Goyal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi, Poonam Negi, Sachin Kumar Singh, Kamal Dua
Summary: Diabetes mellitus is a major global health problem characterized by insufficient insulin secretion and increased blood sugar levels. Current treatment methods include oral antihyperglycemic medications, but they have limitations such as limited effectiveness and side effects. Sodium alginate, a drug delivery mechanism, has potential in solving these issues. This review summarizes the research on using alginate-based drug delivery systems for transporting oral hypoglycemic medicines, phytochemicals, and insulin to treat hyperglycemia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Burcu Tepekule, Katharina Kusejko, Marius Zeeb, Philip E. Tarr, Alexandra Calmy, Manuel Battegay, Hansjakob Furrer, Matthias Cavassini, Enos Bernasconi, Julia Notter, Huldrych F. Guenthard, Johannes Nemeth, Roger D. Kouyos
Summary: This study investigated the link between LTBI and DM in people living with HIV. The results showed that LTBI significantly increased the risk of developing DM, which was robust across different adjustment and censoring techniques.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Remigio Usai, Stephen Majoni, Freeborn Rwere
Summary: The use of medicinal plants and herbs in treating and managing diabetes is an important part of African tradition, particularly in urban areas of Zimbabwe. This review examines indigenous plants found in Zimbabwe and their anti-diabetic properties, as well as the mechanisms of action in treating and managing diabetes. The findings of these studies can contribute to the discovery of new plant-based medicines and promote the regulation of herbal remedies for diabetes by the Zimbabwean government and other African countries.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Lianghua Wen, Dan Wu, Xindong Tan, Meiqi Zhong, Jiabao Xing, Wei Li, Dan Li, Fanrong Cao
Summary: This paper summarizes the important role of catechins in alleviating diabetes and its underlying mechanisms, providing scientific direction for future research on catechin alleviating diabetes.
Article
Immunology
Kennedy Houck, Tsira Chakhaia, Sarah Gorvetzian, Julia A. Critchley, Marcos C. Schechter, Matthew J. Magee
Summary: Diabetes and HIV are independent risk factors for poor outcomes among tuberculosis (TB) patients. This study found that the co-occurrence of diabetes and HIV increases the risk of all-cause mortality during TB treatment, suggesting a potential synergistic effect between these two conditions.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Blanca I. I. Restrepo, Julia M. M. Scordo, Genesis P. Aguillon-Duran, Doris Ayala, Ana Paulina Quirino-Cerrillo, Raul Loera-Salazar, America Cruz-Gonzalez, Jose A. A. Caso, Mateo Joya-Ayala, Esperanza M. M. Garcia-Oropesa, Alejandra B. B. Salinas, Leonardo Martinez, Larry S. S. Schlesinger, Jordi B. B. Torrelles, Joanne Turner
Summary: The elderly population is at high risk of tuberculosis (TB), but there is limited research on this group. This study found a weaker association between TB and type 2 diabetes (T2D) in the elderly compared to younger adults. Additionally, the study discovered that elderly individuals with T2D had better glucose control, lower insulin resistance, and less inflammation compared to younger individuals with T2D.
Article
Medicine, General & Internal
David M. Nathan, GRADE Study Res Grp, John M. Lachin, Ashok Balsubramanyam, Henry B. Burch, John B. Buse, Nicole M. Butera, Robert M. Cohen, Jill P. Crandall, Steven E. Kahn, Heidi Krause-Steinrauf, Mary E. Larkin, Neda Rasouli, Margaret Tiktin, Deborah J. Wexler, Naji Younes
Summary: In this trial, all four glucose-lowering medications added to metformin were effective in reducing glycated hemoglobin levels. Glargine and liraglutide showed modestly superior efficacy in achieving and maintaining target glycated hemoglobin levels.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kosmas Margaritis, Georgia Margioula-Siarkou, Styliani Giza, Eleni P. Kotanidou, Vasiliki Regina Tsinopoulou, Athanasios Christoforidis, Assimina Galli-Tsinopoulou
Summary: Type-1 diabetes mellitus (T1DM) is a well-defined metabolic disorder characterized by hyperglycemia, with a growing incidence in children and adolescents. Recent discoveries of molecules like micro ribonucleic acids (miRNAs) and their interactions with T1DM have provided new insights into disease diagnosis. MiRNAs play a key role in T1DM pathogenesis by interfering with pancreatic b-cell function, insulin production and secretion, and are being studied as potential biomarkers for early diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laura Ferri, Paola Ajdinaj, Marianna Gabriella Rispoli, Claudia Carrarini, Filomena Barbone, Damiano D'Ardes, Margherita Capasso, Antonio Di Muzio, Francesco Cipollone, Marco Onofrj, Laura Bonanni
Summary: While some studies suggest a potential impact of diabetes mellitus on the occurrence of ALS, the correlation between DM and ALS remains unclear. Data indicates a protective role of DM in ALS occurrence in elderly individuals, but an opposite effect in younger subjects.
Review
Biochemistry & Molecular Biology
Alaa M. Abu-Odeh, Wamidh H. Talib
Summary: Diabetes is a global health problem, with the Middle East region showing interest in using traditional medicine and plant extracts to treat the disease. Studies have shown potential antidiabetic activity in plants, particularly those in the Asteraceae and Lamiaceae families, encouraging further research to confirm their medicinal value.
Article
Endocrinology & Metabolism
Ninna Hahn Tougaard, Alexandra Louise Moller, Pernille Falberg Ronn, Tine Willum Hansen, Federica Genovese, Morten Asser Karsdal, Daniel Guldager Kring Rasmussen, Peter Rossing
Summary: The study found that serum endotrophin is a risk marker for kidney and cardiovascular complications in type 2 diabetes, while urine endotrophin is a marker for albuminuria progression.
Article
Immunology
Alok Choudhary, Deendayal Patel, William Honnen, Zhong Lai, Raja Sekhar Prattipati, Ruixiang Blake Zheng, Ying-Chao Hsueh, Maria Laura Gennaro, Alfred Lardizabal, Blanca I. Restrepo, Moncerrato Garcia-Viveros, Maju Joe, Yu Bai, Ke Shen, Kamar Sahloul, John S. Spencer, Delphi Chatterjee, Tobias Broger, Todd L. Lowary, Abraham Pinter
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Jose Cadena, Selvalakshmi Rathinavelu, Juan C. Lopez-Alvarenga, Blanca I. Restrepo
Article
Immunology
Lenette L. Lu, Jishnu Das, Patricia S. Grace, Sarah M. Fortune, Blanca Restrepo, Galit Alter
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Blanca Restrepo, Marcel Twahirwa, Chinnaswamy Jagannath
Summary: The study found that diabetic patients had lower HLA-DR expression in monocytes, with blood triglycerides associated with this reduction and cholesterol counterbalancing the effect. Further research is needed to elucidate the complex interactions between hyperglycemia and dyslipidemias on antigen presentation in diabetic monocytes.
Article
Immunology
Blanca Restrepo, Arshad Khan, Vipul K. Singh, Erica de-Leon, Genesis P. Aguillon-Duran, Eder Ledezma-Campos, David H. Canaday, Chinnaswamy Jagannath
Summary: The study found that MDMs from TB patients had reduced activation of T cells or killing of M. tuberculosis, while MDMs from obese participants had higher antigen presenting capacity and those from chronic diabetes patients had lower Mtb killing capacity. Activation of MDMs with rapamycin enhanced anti-mycobacterial activity regardless of TB status, but was less effective in patients with diabetes.
Article
Multidisciplinary Sciences
Julia M. Scordo, Genesis P. Aguillon-Duran, Doris Ayala, Ana Paulina Quirino-Cerrillo, Emine Rodriguez-Reyna, Francisco Mora-Guzman, Jose A. Caso, Eder Ledezma-Campos, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner, Blanca I. Restrepo
Summary: This study aimed to identify the risk factors for tuberculosis in elderly Hispanics and found that compared to adults, elderly individuals had different risk factors such as male sex, smoking, and low BMI for tuberculosis. Surprisingly, type 2 diabetes was not associated with tuberculosis in the elderly, while BCG vaccination at birth was found to be protective. Further research is needed to address disparities in this vulnerable and understudied population.
Article
Microbiology
Deniz Koyuncu, Muhammad Khalid Khan Niazi, Thomas Tavolara, Claudia Abeijon, Melanie L. Ginese, Yanghui Liao, Carolyn Mark, Aubrey Specht, Adam C. Gower, Blanca I. Restrepo, Daniel M. Gatti, Igor Kramnik, Metin Gurcan, Buelent Yener, Gillian Beamer
Summary: The study identified five protein biomarker candidates using a Diversity Outbred mouse population, with CXCL1 and MMP8 being the most promising. Through statistical and machine learning analysis, CXCL1 was found to meet the World Health Organization's criteria for a triage diagnostic test to distinguish active TB from other conditions in human patients.
Article
Infectious Diseases
Julia M. Scordo, Genesis P. Aguillon-Duran, Doris Ayala, Ana Paulina Quirino-Cerrillo, Emine Rodriguez-Reyna, Mateo Joya-Ayala, Francisco Mora-Guzman, Eder Ledezma-Campos, Alejandro Villafanez, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner, Blanca Restrepo
Summary: IGRAs are suitable for LTBI detection in older people, with more prevalent discordant and inconclusive results in this group, but these can be resolved by repeating the IGRA with a different test.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Jennifer S. Curry, Bassent Abdelbary, Moncerrato Garcia-Viveros, Juan Ignacio Garcia, Marcel Yotebieng, Adrian Rendon, Jordi B. Torrelles, Blanca Restrepo
Summary: The study found that immigrants have a significant impact on the burden of tuberculosis in Tamaulipas, with most immigrants originating from internal migration within Mexico. They have higher risk factors for tuberculosis, such as older age, low education, and diabetes, as well as a higher rate of treatment abandonment.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2021)
Article
Medicine, General & Internal
Genesis P. Aguillon-Duran, Ericka Prieto-Martinez, Doris Ayala, Juan Garcia, John M. Thomas, Juan Ignacio Garcia, Brandon Michael Henry, Jordi B. Torrelles, Joanne Turner, Eder Ledezma-Campos, Blanca Restrepo
Summary: The study alerts to the threat posed by the synergy between coronavirus disease and diabetes on tuberculosis reactivation. It is recommended to implement routine screening for latent tuberculosis infection in these cases and preventive tuberculosis treatment for those who are positive in medium- to high-risk settings for tuberculosis.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Geriatrics & Gerontology
Andreu Garcia-Vilanova, Angelica M. Olmo-Fontanez, Juan Moliva, Anna Allue-Guardia, Harjinder Singh, Robert E. Merritt, Diego J. Maselli, Jay Peters, Blanca Restrepo, Yufeng Wang, Larry S. Schlesinger, Joanne Turner, Susan T. Weintraub, Jordi B. Torrelles
Summary: The alveolar environment in the lungs of older adults is inflammative, oxidative, and dysregulated, potentially affecting immune responses that change with age. We identified 457 differentially expressed proteins in the alveolar lining fluid of older adults, including markers of cellular senescence, antimicrobials, and proteins of neutrophilic granule origin. Furthermore, we propose a hypothetical regulatory network mediated by the serum response factor that could explain the observed neutrophilic profile in the older adult population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mark L. Sowers, Hui Tang, Vipul K. Singh, Arshad Khan, Abhishek Mishra, Blanca I. Restrepo, Chinnaswamy Jagannath, Kangling Zhang
Summary: The study reveals a complex interplay between metabolism, epigenetics, and cell phenotype in macrophage polarization. M1 macrophages showed globally reduced histone acetylation levels but high levels of acetylated amino acids, suggesting a diversion of acetyl-CoA toward acetylated amino acids. Meanwhile, M2 macrophages exhibited high levels of kynurenine and serotonin, which are known to have immune-suppressive effects.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Microbiology
Blanca I. I. Restrepo, Julia M. M. Scordo, Genesis P. Aguillon-Duran, Doris Ayala, Ana Paulina Quirino-Cerrillo, Raul Loera-Salazar, America Cruz-Gonzalez, Jose A. A. Caso, Mateo Joya-Ayala, Esperanza M. M. Garcia-Oropesa, Alejandra B. B. Salinas, Leonardo Martinez, Larry S. S. Schlesinger, Jordi B. B. Torrelles, Joanne Turner
Summary: The elderly population is at high risk of tuberculosis (TB), but there is limited research on this group. This study found a weaker association between TB and type 2 diabetes (T2D) in the elderly compared to younger adults. Additionally, the study discovered that elderly individuals with T2D had better glucose control, lower insulin resistance, and less inflammation compared to younger individuals with T2D.
Article
Public, Environmental & Occupational Health
Juan Ignacio Garcia, Anna Allue-Guardia, Radhika P. Tampi, Blanca Restrepo, Jordi B. Torrelles
Summary: The alignment of sustainable development goals with the End Tuberculosis strategy provides an integrated roadmap for TB elimination. Recent advancements in TB diagnosis and vaccines, including non-sputum based TB biomarkers, whole genome sequencing technologies, mRNA vaccination, nanovaccines, and promising TB vaccine models, offer promising developments for TB prevention and control in the context of global health transformation. However, addressing TB social determinants and implementing sustainable universal health coverage and social protection are essential for achieving TB elimination as emphasized by the End TB strategy and SDGs.
CURRENT EPIDEMIOLOGY REPORTS
(2021)
Article
Public, Environmental & Occupational Health
H. A. Rashak, H. J. Sanchez-Perez, B. E. Abdelbary, A. Bencomo-Alerm, N. Enriquez-Rios, A. Gomez-Velasco, A. Colorado, M. Castellanos-Joya, M. H. Rahbar, B. Restrepo
EPIDEMIOLOGY AND INFECTION
(2019)