Article
Biochemistry & Molecular Biology
Leonardo Pazarin-Villasenor, Yessica Garcia-Salas, Francisco Gerardo Yanowsky-Escatell, Fermin Paul Pacheco-Moises, Jorge Andrade-Sierra, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Andres Garcia-Sanchez, Alejandra Guillermina Miranda-Diaz
Summary: This study investigated the oxidative stress status in peritoneal dialysis patients with type 2 diabetes mellitus. The levels of lipoperoxides and oxidative DNA damage markers were found to be significantly increased in patients with and without diabetes, while the activity of antioxidant enzymes was also increased. Antioxidant enzymes could be a promising therapeutic strategy for the management of chronic kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Li-Ying He, Yong Li, Shu-Qi Niu, Jing Bai, Si-Jing Liu, Jin-Lin Guo
Summary: Diabetes mellitus is a metabolic disease characterized by high blood sugar levels. Oxidative stress plays a significant role in its development, especially in type 2 diabetes and metabolic syndrome. Natural polysaccharides, derived from plants, microorganisms, and marine organisms, have been found to have antioxidant activity and therapeutic effects in diabetes. This paper summarizes the natural polysaccharides with therapeutic potential for diabetes in the past 5 years, providing insights into their pharmacological mechanisms and identified structures, which can be valuable for the development of new diabetic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Biochemical Research Methods
Sarah C. Skinner, Travis Nemkov, Mor Diaw, Maimouna Ndour Mbaye, Demba Diedhiou, Djiby Sow, Fatou Gueye, Philomene Lopez, Philippe Connes, Angelo D'Alessandro
Summary: Epidemiological data suggests that the prevalence of type 2 diabetes (T2D) will increase the most in sub-Saharan Africa over the next two decades. Metabolomics studies have identified biomarkers that could enhance T2D diagnosis and monitoring. However, there is a lack of research on the metabolome of individuals from sub-Saharan Africa.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Clinical Neurology
Joan Vicent Sanchez-Orti, Patricia Correa-Ghisays, Vicent Balanza-Martinez, Gabriel Selva-Vera, Joan Vila-Frances, Rafael Magdalena-Benedito, Constanza San-Martin, Victor M. Victor, Irene Escribano-Lopez, Antonio Hernandez-Mijares, Juliana Vivas-Lalinde, Benedicto Crespo-Facorro, Rafael Tabares-Seisdedos
Summary: This study aimed to identify peripheral biomarkers suitable to signal memory decline from a transdiagnostic and longitudinal perspective. The results showed that inflammation and lipid metabolism are associated with memory problems in various conditions such as diabetes and severe mental illnesses. A panel of biomarkers may be an effective approach to identify individuals at risk of neurocognitive impairment. These findings have potential implications for early intervention and precision medicine in these disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
George-Alexandru Maftei, Maria-Alexandra Martu, Marius-Cristian Martu, Dora Popescu, Petra Surlin, Diana Tatarciuc, Cristina Popa, Liliana-Georgeta Foia
Summary: The study showed that various oxidative status markers and proinflammatory biomarkers in the saliva of diabetic patients were altered before and after tooth extraction, correlating with HbA1c levels and potentially serving as indicators of post-extraction healing status in the oral cavity.
Review
Biochemistry & Molecular Biology
Rosaria Vincenza Giglio, Anca Pantea Stoian, Martin Haluzik, Kalliopi Pafili, Angelo Maria Patti, Ali Abbas Rizvi, Marcello Ciaccio, Nikolaos Papanas, Manfredi Rizzo
Summary: Diabetes is a major risk factor for cardiovascular disease, with high blood glucose leading to increased reactive oxygen species and affecting endothelial function and atherosclerotic plaque formation. Biomarkers play a crucial role in screening, prediction, diagnosis, and monitoring of cardiovascular risks associated with diabetes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Article
Nutrition & Dietetics
Lulu Wang, Xue Liu, Jian Hou, Dandan Wei, Pengling Liu, Keliang Fan, Li Zhang, Luting Nie, Xing Li, Wenqian Huo, Tao Jing, Wenjie Li, Chongjian Wang, Zhenxing Mao
Summary: This study found a negative correlation between serum vitamin D and impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), as well as a negative correlation between serum 25(OH)D-2 and total 25(OH)D levels. The lipid profile, specifically total cholesterol (TC) and triglyceride (TG), partially mediated the relationship between vitamin D and IFG or T2DM. Additionally, there were interactive effects of serum 25(OH)D-2, total 25(OH)D, and testosterone on T2DM in females.
Article
Medicine, General & Internal
Alexandra Halalau, Sujoy Roy, Arpitha Hegde, Sumesh Khanal, Emily Langnas, Maidah Raja, Ramin Homayouni
Summary: This study aimed to determine the risk factors associated with rapid progression from normal or prediabetic hemoglobin A1c levels to type 2 diabetes mellitus. The results showed that progression to diabetes within a four-year period is associated with baseline BMI. A steady rise in HbA1c during the same period is associated with age and family history of type 2 diabetes, while rapid rise in HbA1c is associated with age and personal history of major cardiovascular events.
ANNALS OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Abdel-Moneim Hafez Abdel-Moneim, Mohamed Faisal Lutfi, Ashwag Saleh Alsharidah, Gehan Shaker, Waleed Faisal, Ahmed A. H. Abdellatif, Osamah Al Rugaie, Khalid M. Mohany, Safaa Yehia Eid, Mahmoud Zaki El-Readi, Mansour Alsharidah
Summary: The study showed that the therapeutic benefits of metformin and glipizide are complementary, with metformin performing better in improving glycemic control and reducing oxidative stress, while glipizide was more effective against dyslipidemia. The findings could be useful for the treatment of future vascular patients, antilipidemic medicines, and antioxidant therapy to enhance the quality of life.
APPLIED SCIENCES-BASEL
(2022)
Article
Endocrinology & Metabolism
Sabaa Joad, Elliot Ballato, F. N. U. Deepika, Giulia Gregori, Alcibiades Leonardo Fleires-Gutierrez, Georgia Colleluori, Lina Aguirre, Rui Chen, Vittoria Russo, Virginia Carolina Fuenmayor Lopez, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study aims to identify a hemoglobin A1c threshold level by which reduction in bone turnover begins in men with type 2 diabetes mellitus. Results show that an A1c level of 7% or greater is associated with lower bone turnover in the study population and specifically in men with T2D.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anju Singh, Ritushree Kukreti, Luciano Saso, Shrikant Kukreti
Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.
Article
Cell Biology
Annadurai Thangaraj, Palsamy Periyasamy, Ming-Lei Guo, Ernest T. Chivero, Shannon Callen, Shilpa Buch
Article
Ophthalmology
Thiraviyam Anand, Muniyandi Anbukkarasi, P. Archana Teresa, Philip Aloysius Thomas, Pitchairaj Geraldine
CURRENT EYE RESEARCH
(2020)
Review
Neurosciences
Shilpa Buch, Palsamy Periyasamy, Annadurai Thangaraj, Susmita Sil, Ernest T. Chivero, Ashutosh Tripathi
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2020)
Article
Clinical Neurology
Ashutosh Tripathi, Annadurai Thangaraj, Ernest T. Chivero, Palsamy Periyasamy, Maria E. Burkovetskaya, Fang Niu, Ming-Lei Guo, Shilpa Buch
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Ernest T. Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buch
Summary: Cocaine induces microglial activation through the NLRP3 inflammasome pathway, leading to neuroinflammation. Inhibition of ROS and NLRP3 can attenuate cocaine-induced NLRP3 activation and microglial activation. NLRP3 may be a potential therapeutic target for alleviating cocaine-induced neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Susmita Sil, Annadurai Thangaraj, Ernest T. Chivero, Fang Niu, Muthukumar Kannan, Ke Liao, Peter S. Silverstein, Palsamy Periyasamy, Shilpa Buch
Summary: Various research studies have explored the impact of drug abuse on HIV infection and disease progression, highlighting the impairments in host immunological and non-immunological pathways. Despite efforts to develop rodent models of HAND, none can fully replicate the complex pathophysiology of the syndrome, but they do model some unique aspects of HAND.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Annadurai Thangaraj, Ernest T. Chivero, Ashutosh Tripathi, Seema Singh, Fang Niu, Ming-Lei Guo, Prakash Pillai, Palsamy Periyasamy, Shilpa Buch
Summary: The use of cART in HIV-infected individuals has led to increased life expectancy but also a higher prevalence of age-related comorbidities such as HIV-associated neurocognitive disorders. This study revealed that HIV TAT protein can induce a senescence-like phenotype in microglial cells, involving oxidative stress and inflammation. Modulation of the miR-505-SIRT3 axis could potentially reduce microglial senescence caused by HIV TAT.
Article
Infectious Diseases
Susmita Sil, Palsamy Periyasamy, Annadurai Thangaraj, Fang Niu, Divya T. Chemparathy, Shilpa Buch
Summary: This review summarizes the characteristics of HIV-associated neurocognitive disorders (HAND), factors contributing to HAND, and functional impairments in preclinical and clinical models. Recent advances in animal models of HAND, in vitro cultures, and the potential role of drugs of abuse in HAND are also discussed. Potential peripheral biomarkers associated with HAND are highlighted as well.
CURRENT HIV/AIDS REPORTS
(2021)
Article
Pharmacology & Pharmacy
Thiraviyam Anand, Muniyandi Anbukkarasi, Philip Aloysius Thomas, Pitchairaj Geraldine
Summary: The study aimed to enhance the antioxidant and anticataractogenic properties of eugenol by encapsulating it in chitosan nanoparticles. The nanoparticles ranged in size from 200-600 nm and showed protective effects on human lenticular epithelial cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Neurosciences
Ernest T. Chivero, Susmita Sil, Seema Singh, Annadurai Thangaraj, Lila Gordon, Grace B. Evah-Nzoughe, Natasha Ferguson, Shannon Callen, Shilpa Buch
Summary: The study found that the probiotic Lactobacillus rhamnosus has a protective effect against cocaine-induced oxidative stress, glial activation, and locomotion in mice. Administration of L. rhamnosus attenuated gut oxidative stress and inflammation, as well as glial activation and locomotion induced by cocaine. These results suggest the potential of microbial-based interventions in reducing cocaine-mediated behavioral responses and neuroinflammation.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Palsamy Periyasamy, Annadurai Thangaraj, Muthukumar Kannan, Abiola Oladapo, Shilpa Buch
Summary: The study reveals that exposure of mouse primary microglial cells to both HIV-1 Tat and cocaine leads to a significant increase in promoter DNA methylation of miR-124, intensifying microglial activation and ultimately culminating in neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Susmita Sil, Annadurai Thangaraj, Abiola Oladapo, Guoku Hu, Naseer A. Kutchy, Ke Liao, Shilpa Buch, Palsamy Periyasamy
Summary: Chronic low-grade inflammation is a key feature in HIV-1 infected individuals, even under combined antiretroviral therapy (cART), and contributes to cognitive defects and aging. Drug abuse exacerbates the cognitive defects by activating cells in the central nervous system (CNS) and causing neurotoxin release, leading to neuroinflammation. Impaired autophagy, caused by exposure to HIV-1/HIV-1 proteins, cART, and drug abuse, plays a role in neuroinflammaging and immune senescence.
Article
Biochemistry & Molecular Biology
Prakash P. P. Pillai, Muthukumar Kannan, Susmita Sil, Seema Singh, Annadurai Thangaraj, Ernest T. T. Chivero, Raghubendra Singh Dagur, Ashutosh Tripathi, Guoku Hu, Palsamy Periyasamy, Shilpa Buch
Summary: HIV-1 infection is associated with premature aging, and astrocyte senescence mediated by lncRNA TUG1 contributes to HIV-1-induced brain aging and neurocognitive impairments. Silencing TUG1 expression can reverse HIV-1 Tat-induced astrocyte senescence. This study suggests that targeting lncRNA TUG1 may be a potential therapeutic strategy for combating accelerated aging in HIV-1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Antony A. Baskaran, Tanuja Britto, Raja T. Sowndher, Philip A. Thomas
Summary: The study compared the performance of different methods of NPC measurement among patients with various refractive errors. The results showed that hypermetropes performed poorly in the RG test, while myopes had better results with the PR test. There was disagreement between the methods, and variability varied among patients with different refractive errors.
SAUDI JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Muniyandi Anbukkarasi, Philip A. Thomas, P. Archana Teresa, Thiraviyam Anand, Pitchairaj Geraldine
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
