Article
Endocrinology & Metabolism
Xiaoyan Huang, Ya Gao, Houkang Cao, Jun Li, Siyi Mo, Ting Li, Jianzhao Wu, Kai Guo, Riming Wei, Kefeng Zhang
Summary: This study demonstrates that Scoparone has a therapeutic effect in non-alcoholic fatty liver disease (NAFLD) and the underlying mechanism involves the regulation of cholesterol and fatty acid metabolism. This finding is important for understanding the pathogenesis of NAFLD and providing new treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yunchen Luo, Zhijian Zhang, Liping Xiang, Bing Zhou, Xuejiao Wang, Yi Lin, Xiaoying Ding, Fang Liu, Yan Lu, Yongde Peng
Summary: The study demonstrates a positive correlation between m6A methylation modifications and NAFLD, with enrichment in lipid metabolism processes. Both high fructose diet and leptin receptor deficiency result in up-regulation of genes related to lipid metabolism pathways, but different regulation of immune inflammatory response genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Health Care Sciences & Services
Laura Valenzuela-Vallejo, Despina Sanoudou, Christos S. Mantzoros
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with various complications. The lack of non-invasive diagnosis and effective treatment calls for a more specific subcategorization of fatty liver disease (FLD). A precision medicine approach based on subcategorization is expected to improve patient care and reduce healthcare costs associated with FLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Review
Pharmacology & Pharmacy
Marziyeh Anari, Magdalene K. Montgomery
Summary: Mammalian cells contain a wide variety of glycerophospholipid species, with phosphatidylserine (PS) playing a crucial role in various physiological processes. PS is involved in apoptosis, blood clotting, cancer pathogenesis, and muscle and brain function. Recent studies have focused on the role of hepatic PS in non-alcoholic fatty liver disease (NAFLD) and liver cancer progression. This review provides a comprehensive overview of hepatic phospholipid metabolism and delves into the metabolism of PS in advanced liver disease.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Qingmin Zeng, Chang-Hai Liu, Dongbo Wu, Wei Jiang, Nannan Zhang, Hong Tang
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Long non-coding RNA (lncRNA) and circular RNA (circRNA) have emerged as potential non-invasive biomarkers for predicting NAFLD. This systematic review highlights the potential of lncRNA and circRNA, such as NEAT1, MEG3, MALAT1, and SCAR, for early diagnosis and progression assessment of NAFLD, NASH, and fibrosis. Large-cohort studies and further exploration of the functional mechanisms are needed to validate their clinical value.
Article
Medicine, General & Internal
Ines Mateus, Carina Prip-Buus
Summary: Hydrogen sulphide (H2S) was previously seen as a toxic gas and environmental pollutant, but is now recognized as the third mammalian gasotransmitter with key roles in inflammation and diseases. In the liver, H2S plays a crucial role in glucose and lipid metabolism and may have implications in chronic liver diseases. Further research is needed to understand the physiological relevance of mitochondrial H2S oxidation and its impact on liver energy homeostasis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Oxana M. Drapkina, Anastasia Yu. Elkina, Anna F. Sheptulina, Anton R. Kiselev
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing global epidemic, expected to increase rapidly in the future. It is linked to insulin resistance and other metabolic conditions. The association between NAFLD and osteoporosis has been studied, but further research is needed to explore this relationship in younger patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Arun J. Sanyal, Sudha S. Shankar, Katherine P. Yates, James Bolognese, Erika Daly, Clayton A. Dehn, Brent Neuschwander-Tetri, Kris Kowdley, Raj Vuppalanchi, Cynthia Behling, James Tonascia, Anthony Samir, Claude Sirlin, Sarah P. Sherlock, Kathryn Fowler, Helen Heymann, Tania N. Kamphaus, Rohit Loomba, Roberto A. Calle
Summary: There is currently no approved diagnostic biomarker for at-risk non-alcoholic steatohepatitis (NASH), which is associated with higher incidence of liver-related events and mortality. The FNIH-NIMBLE project evaluated the diagnostic performance of five blood-based panels in individuals with non-alcoholic fatty liver disease (NAFLD). Several biomarkers showed promising results in diagnosing at-risk NASH and assessing fibrosis severity.
Article
Biochemistry & Molecular Biology
Alvaro Santos-Laso, Maria Gutierrez-Larranaga, Marta Alonso-Pena, Juan M. Medina, Paula Iruzubieta, Maria Teresa Arias-Loste, Marcos Lopez-Hoyos, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by excessive accumulation of liver fat due to high-caloric intake and/or cellular and molecular abnormalities. It is closely associated with obesity and type 2 diabetes mellitus. Currently, lifestyle changes are the only effective treatment, but they are often difficult to implement and maintain. Therefore, research efforts are focused on understanding the underlying pathological mechanisms and identifying new therapeutic targets.
Review
Gastroenterology & Hepatology
Cheng Chang, Huicong Li, Ruilin Zhang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing metabolic disease worldwide. Zebrafish, with their genetic and metabolic similarity to mammals, as well as unique advantages such as high fecundity and optical transparency, have become an emerging model for studying liver and metabolic diseases. In this review, we summarize the tools and models used in zebrafish NAFLD research, including dietary feeding, chemical treatments, and genetic manipulations. We also discuss how zebrafish models contribute to our understanding of NAFLD pathogenesis, toxicology, and drug evaluation.
LIVER INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Xingchun Wang, Bangfeng Zhao, Hang Sun, Hui You, Shen Qu
Summary: This study aimed to evaluate the effects of sitagliptin on intrahepatic lipid (IHL) content in patients with nonalcoholic fatty liver disease (NAFLD). The results showed that sitagliptin improved glucose metabolism abnormalities but did not directly reduce IHL in patients with NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaomeng Chen, Hong Ma, Yan Gao, Ye Jin, Wei Ning, Yue Hou, Jianrong Su
Summary: Nonalcoholic fatty liver disease (NAFLD) is associated with high morbidity rates. This study identified that the lncRNA AC012668 was significantly suppressed in NAFLD models and its overexpression could inhibit lipogenesis-related gene expression and lipid accumulation. Additionally, miR-380-5p was found to target AC012668 and LRP2, playing a role in NAFLD progression. These findings suggest a potential novel strategy for combating NAFLD.
Editorial Material
Gastroenterology & Hepatology
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Summary: The review highlights the crucial role of gut microbes in maintaining liver homeostasis and the impact of dysbiosis on the development of fatty liver disease. The changes in gut microbial composition in alcoholic and nonalcoholic fatty liver diseases and how they contribute to the pathophysiology of the disease are discussed. New approaches related to gut microbes for the diagnosis and treatment of fatty liver disease are also summarized.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chia-Jung Liao, Po-Shuan Huang, Hui-Tzu Chien, Tzu-Kang Lin, Chau-Ting Yeh, Kwang-Huei Lin
Summary: The typical modern lifestyle contributes to the development of metabolic disorders. Thyroid hormones play an important role in liver lipid metabolism and have potential applications in the management of non-alcoholic fatty liver disease (NAFLD).