Article
Endocrinology & Metabolism
Aziz Sener, Selin Yildiz, Gulce Kiren, Canan Topcuoglu
Summary: New inflammatory markers are useful in assessing albuminuria in T2DM patients, but not in assessing glycemic control.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Endocrinology & Metabolism
Katie M. Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger, Farid H. Mahmud, Alison B. Dart
Summary: The study found significant associations between podocyte MPE, blood glucose levels and eGFR in youth with type 1 diabetes, but not in those with type 2 diabetes, despite increased renal pathology in the type 2 diabetes cohort.
Article
Medicine, General & Internal
Hertzel C. Gerstein, Naveed Sattar, Julio Rosenstock, Chinthanie Ramasundarahettige, Richard Pratley, Renato D. Lopes, Carolyn S. P. Lam, Nardev S. Khurmi, Laura Heenan, Stefano Del Prato, Leanne Dyal, Kelley Branch
Summary: The trial compared the cardiovascular and renal outcomes of weekly injections of efpeglenatide versus a placebo in participants with type 2 diabetes and a history of cardiovascular disease or current kidney disease. The study found that the risk of cardiovascular events was lower with efpeglenatide treatment, and a composite renal outcome event was also reduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Kerstin Brismar, Agneta Hilding, Ishrath Ansurudeen, Allan Flyvbjerg, Jan Frystyk, Claes-Goran Ostenson
Summary: Adiponectin, IGFBP-1, and IGFBP-2 are biomarkers of insulin sensitivity. Low levels of adiponectin, IGFBP-1, and IGFBP-2 are independently associated with future abnormal glucose tolerance in both genders. In women, IGFBP-2 is the strongest predictor for prediabetes, while adiponectin is the strongest predictor for type 2 diabetes. In men, IGFBP-1 is the strongest predictor for both prediabetes and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou
Summary: This study investigated the association of soluble Tumour Necrosis Factor Receptor 1 (sTNF-R1), sTNF-R2, and endostatin with new onset microalbuminuria in patients with type 2 diabetes. The results showed that endostatin and sTNF-R1 were increased at baseline, but sTNF-R2 did not increase. However, these factors were not effective in predicting the occurrence of microalbuminuria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study explores the relationship between plasma LRG1 level and urinary albumin excretion in patients with type 2 diabetes. The results show that there is a positive correlation between plasma LRG1 level and urinary albumin excretion, indicating that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Javier Donate-Correa, Ernesto Martin-Nunez, Carmen Mora-Fernandez, Ainhoa Gonzalez-Luis, Alberto Martin-Olivera, Juan F. Navarro-Gonzalez
Summary: In this study, the association between inflammation, hemoglobin, and coronary artery disease (CAD) in subjects with type 2 diabetes mellitus (T2DM) and preserved kidney function was evaluated. The findings suggest that inflammation markers may not be related to the severity of stenosis in subjects with diabetes, while reductions in hemoglobin levels may be a more important risk factor for CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Marc Clos-Garcia, Tarunveer S. S. Ahluwalia, Signe A. A. Winther, Peter Henriksen, Mina Ali, Yong Fan, Evelina Stankevic, Liwei Lyu, Josef K. K. Vogt, Torben Hansen, Cristina Legido-Quigley, Peter Rossing, Oluf Pedersen
Summary: By studying the gut microbiome and blood metabolome of individuals with type 1 diabetes (T1D) and healthy controls, we identified distinct features in the microbiome and metabolome of individuals with T1D and progressive kidney disease stratified on levels of albuminuria.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elisa Lazzaroni, Maria Elena Lunati, Laura Montefusco, Ida Pastore, Enrica Chebat, Vincenzo Cimino, Paola Silvia Morpurgo, Milena Muratori, Laura Plebani, Andrea Bolla, Antonio Rossi, Luciana Vallone, Alessandra Gandolfi, Camilla Tinari, Francesca D'Addio, Moufida Ben Nasr, Cristian Loretelli, Cristiana Scaranna, Rosalia Bellante, Roberto Manfrini, Fabrizio Muratori, Ivano Franzetti, Emanuela Orsi, Carmine Gazzaruso, Renata Ghelardi, Paolo Desenzani, Stefano Genovese, Angela Girelli, Franco Folli, Cesare Berra, Paolo Fiorina
Summary: This study aimed to investigate the acute effect of Dapagliflozin on kidney function in patients with type 2 diabetes. The results showed that after 6 months of treatment with Dapagliflozin, there were improvements in glycemic control, lipid profiles, blood pressure, and acute kidney function.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Morten B. Houlind, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Juliette Tavenier, Jesper Eugen-Olsen, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J. L. Heerspink
Summary: The effect of four different drug classes on suPAR levels in people with type 1 and type 2 diabetes was evaluated. The study showed no overall effect of the drugs on suPAR levels, but individualized treatment significantly reduced suPAR levels.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Ninna H. Tougaard, Marie Frimodt-Moller, Hanne Salmenkari, Elisabeth B. Stougaard, Andressa D. Zawadzki, Ismo M. Mattila, Tine W. Hansen, Cristina Legido-Quigley, Sohvi Horkko, Carol Forsblom, Per-Henrik Groop, Markku Lehto, Peter Rossing
Summary: This study investigated the effects of butyrate on inflammation, kidney function, metabolites, and gastrointestinal symptoms in individuals with type 1 diabetes, albuminuria, and intestinal inflammation. The results showed that 12 weeks of butyrate supplementation did not reduce intestinal inflammation in these individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rupjyoti Talukdar, Priyanka Sarkar, Aparna Jakkampudi, Subhaleena Sarkar, Mohsin Aslam, Manasa Jandhyala, G. Deepika, Misbah Unnisa, D. Nageshwar Reddy
Summary: This study found significant differences in gut microbiome composition between patients with diabetes secondary to chronic pancreatitis and other types of diabetes, including species richness, beta diversity, and unique bacterial species.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Bin Wang, Heng Wan, Jing Cheng, Yingchao Chen, Yuying Wang, Yi Chen, Chi Chen, Wen Zhang, Fangzhen Xia, Ningjian Wang, Li Wang, Yingli Lu
Summary: Higher blood lead levels were associated with increased urinary albumin excretion in diabetic patients with vitamin D deficiency. However, this association was attenuated or non-significant in patients with sufficient vitamin D levels. The combination of high blood lead and low vitamin D levels corresponded to significantly higher urinary albumin-to-creatinine ratio. It was also found that the impact of blood lead levels on urinary albumin excretion was more pronounced in patients with reduced estimated glomerular filtration rate in the group with vitamin D deficiency.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hui Tang, Yeh-Han Wang, Chin-Chang Chen, Chia-Jung Chan, Fuu-Jen Tsai, Shih-Yin Chen
Summary: This study investigates the expression of adiponectin in T2DM mice and explores the genetic distribution of adiponectin gene polymorphisms in a Taiwanese population. It also measures serum adiponectin protein concentrations in T2DM patients. The findings suggest that adiponectin may be involved in T2DM susceptibility and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zhigao Song, Cong Chen, Jipei He, Bixia Liu, Weidong Ji, Liangping Wu, Li He
Summary: This study found that AIP1 plays a crucial role in the development of type 2 diabetes. It regulates the expression of TNF-alpha through multiple inflammatory pathways. AIP1 deficiency leads to increased inflammatory factors and impairs glucose uptake. The loss of AIP1 in human adipocytes activates the JNK, p38 MAPK, and ERK1/2 signaling pathways, and inhibition of these pathways can alleviate insulin resistance caused by AIP1 deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Correction
Urology & Nephrology
Mariana Ciorba Pop, Alina Ramona Potra, Cosmina Ioana Bondor, Diana Moldovan, Crina Claudia Rusu, Dan Stefan Vladutiu, Ina Maria Kacso
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2017)
Article
Urology & Nephrology
Olga Hilda Orasan, Aniela Pop Saplontai, Angela Cozma, Simona Racasan, Ina Maria Kacso, Crina Claudia Rusu, Diana Moldovan, Dacian Tirinescu, Alina Potra, Ioan Mihai Patiu, Remus Aurel Orasan
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2017)
Article
Urology & Nephrology
Diana Moldovan, Crina Rusu, Alina Potra, Ioan Moldovan, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Maria Kacso
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2017)
Article
Hematology
Dacian Calin Tirinescu, Ciprian Tomuleasa, Laura Pop, Cosmina Ioana Bondor, Dan Stefan Vladutiu, Ioan Mihai Patiu, Crina Claudia Rusu, Diana Tania Moldovan, Alina Potra, Ina Maria Kacso
THERAPEUTIC APHERESIS AND DIALYSIS
(2017)
Article
Urology & Nephrology
Crina Claudia Rusu, Simona Racasan, Diana Moldovan, Alina Potra, Dacian Tirinescu, Cristian Budurea, Remus Orasan, Ioan Mihai Patiu, Cosmina Bondor, Dan Vladutiu, Dan Delean, Alexandra Danu, Ina Maria Kacso
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2018)
Article
Urology & Nephrology
Maria Ticala, Dacian Calin Tirinescu, Crina Claudia Rusu, Diana Moldovan, Alina Ramona Potra, Anca Laura Coman, Cosmina Loana Bondor, Livia Budisan, Ina Maria Kacso
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2019)
Article
Peripheral Vascular Disease
Maria Ticala, Crina Claudia Rusu, Diana Moldovan, Alina Ramona Potra, Dacian Calin Tirinescu, Anca Laura Coman, Cosmina Ioana Bondor, Livia Budisan, Ina Maria Kacso
Summary: The objective of this study was to evaluate the association between VCAM-1, sRAGE, and CML with arteriovenous fistula dysfunction (AVF). The results showed that patients with AVF dysfunction had significantly higher levels of VCAM-1 and a positive correlation was identified between VCAM-1 and sRAGE in this group.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Urology & Nephrology
Diana Moldovan, Crina Rusu, Alina Potra, Cosmina Bondor, Maria Ticala, Dacian Tirinescu, Anca Coman, Olga Orasan, Ioan Moldovan, Remus Orasan, Ina Kacso
Summary: This study found that factors such as AIC, high OPG levels, low ankle-arm index, diabetes, smoking, and lack of arteriovenous fistula are associated with all-cause and cardiovascular mortality in chronic hemodialysis patients. Multivariate analysis identified AIC scoring based on the segmentation method and increased OPG levels as independent predictors of mortality.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Hematology
Maria Ticala, Crina Claudia Rusu, Diana Moldovan, Alina Ramona Potra, Dacian Calin Tirinescu, Anca Laura Coman, Cosmina Ioana Bondor, Livia Budisan, Ina Maria Kacso
Summary: In this study, serum levels of sRAGE were found to be associated with AVF thrombosis and failure in HD patients. Higher levels of sRAGE were linked to shorter AVF patency time, indicating a significant impact on AVF survival. Other factors such as baseline stenosis, serum albumin, obesity, and ischemic heart disease were also associated with thrombosis in this patient population.
BLOOD PURIFICATION
(2022)
Article
Medicine, General & Internal
Crina Claudia Rusu, Ina Kacso, Diana Moldovan, Alina Potra, Dacian Tirinescu, Maria Ticala, Ancuta M. M. Rotar, Remus Orasan, Cristian Budurea, Andrada Barar, Florin Anton, Ana Valea, Cosmina Ioana Bondor, Madalina Ticolea
Summary: Cardiovascular diseases are the leading cause of mortality in patients with chronic kidney disease. This study evaluated the impact of nutritional, hormonal, and inflammatory markers on brachial-ankle Pulse Wave Velocity in pre-dialysis CKD patients. The results showed that reduced muscle mass, low levels of total cholesterol, triglycerides, triiodothyronine, and prolactin were associated with high Pulse Wave Velocity, as well as advanced age.
Meeting Abstract
Transplantation
Alina Ramona Potra, Teodor Paul Kacso, Alexandra Maria Gavrilas, Crina Claudia Rusu, Crina Claudia Rusu, Crina Claudia Rusu, Diana Moldovan, Cosmina Ioana Bondor, Dacian Tirinescu, Laura Anca Coman, Ina Maria Kacso
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Meeting Abstract
Transplantation
Crina-Claudia Rusu, Simona Racasan, Ina-Maria Kacso, Diana Moldovan, Alina Potra, Cosmina Bondor, Remus Orasan, Ioan Mihai Patiu, Cristian Budurea, Dacian Tirinescu, Maria Ticala, Anca Coman, Alexandra Danu
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Meeting Abstract
Transplantation
Diana Moldovan, Crina Rusu, Alina Potra, Dacian Tirinescu, Anca Coman, Maria Ticala, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Kacso
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Meeting Abstract
Transplantation
Dacian Calin Tirinescu, Ciprian Tomuleasa, Laura Pop, Cosmina Bondor, Dan Vladuaiu, Ioan Patiu, Crina Rusu, Diana Moldovan, Alina Potra, Ina Kacso
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2017)
Meeting Abstract
Transplantation
Crina-Claudia Rusu, Simona Racasan, Ina-Maria Kacso, Diana Moldovan, Alina Potra, Cosmina Bondor, Remus Orasan, Ioan Mihai Patiu, Cristian Budurea, Dacian Tirinescu, Alexandra Danu, Dan Delean
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2017)