期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 96, 期 3, 页码 348-354出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.01.009
关键词
Broccoli sprouts; Lipid profiles; Oxidized LDL cholesterol; Type 2 diabetes
资金
- Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background and aims: In this study, broccoli sprout powder (BSP), a good source of bioactive components, was used as supplementary treatment in type 2 diabetic patients. Methods: This randomized clinical trial included 81 patients with type 2 diabetes. Participants were randomly assigned to consume 10 g/d BSP (group A), 5 g/d BSP (group B), or the placebo (group C), each for 4 weeks. Fasting blood glucose (FBS), total cholesterol (TC), triglyceride concentration (TG), LDL-C, HDL-C, and oxidized-LDL were measured at baseline and 4 weeks after treatment. The ratios of OX-LDL/LDL, atherogenic index of plasma (AIP; log TG/HDL), TC/HDL and LDL/HDL were calculated as cardiovascular risk factors parameters, at baseline and 4 weeks after treatment. Results: Seventy-two patients completed the study; n = 23, 26 and 23 for groups A, B and C, respectively. After 4 weeks, BSP in dose of 10 g/d, significantly decreased serum triglycerides, OX-LDL/LDL ratio and AIP (p < 0.05 for treatment effect). HDL-C concentration was significantly higher (p < 0.01 for treatment) in group A as compared with group B and placebo. Conclusions: BSP as supplementary treatment in type 2 diabetes could have favorable effects on lipid profiles and OX-LDL/LDL ratio, as risk factors for cardiovascular disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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