Article
Endocrinology & Metabolism
Zhenjie Teng, Jing Feng, Ronghui Liu, Yanhong Dong, Huifang Chen, Jing Xu, Xin Jiang, Rui Li, Peiyuan Lv
Summary: This study found that different imaging markers of cerebral small vessel disease (CSVD), particularly total CSVD burden, were associated with an increased risk of mild cognitive impairment (MCI) and decline in Montreal Cognitive Assessment (MoCA) scores in patients with type 2 diabetes mellitus (T2DM). These findings provide clues for future studies to explore early diagnostic imaging markers of cognitive impairment in relation to T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Cell Biology
Cameron D. Owens, Camila Bonin Pinto, Sam Detwiler, Peter Mukli, Anna Peterfi, Zsofia Szarvas, Jordan R. Hoffmeister, Juliette Galindo, Jila Noori, Angelia C. Kirkpatrick, Tarun W. Dasari, Judith James, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari, Calin I. Prodan, Andriy Yabluchanskiy
Summary: COVID-19 may independently and through exacerbation of age-related mechanisms contribute to increased incidence of cerebral small vessel disease (CSVD). The study evaluated CSVD in acute and recovered COVID-19 patients and differentiated COVID-19-related cerebrovascular pathology from age-related comorbidities and medical interventions.
AGEING RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Zhenjie Teng, Jing Feng, Yanhong Dong, Jing Xu, Xin Jiang, Huifang Chen, Qianqian Qi, Rui Li, Weihong Chen, Peiyuan Lv
Summary: The study found a correlation between Triglyceride glucose (TyG) index and cerebral small vessel disease (CSVD) burden, as well as cognitive function in elderly patients with type 2 diabetes mellitus (T2DM). An increased TyG index was associated with an increased risk of cognitive impairment and severe CSVD burden. The study also found that severe CSVD burden moderated the association between higher TyG index levels and cognitive impairment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ruihan Zhu, Yunjing Li, Lina Chen, Yingqing Wang, Guoen Cai, Xiaochun Chen, Qinyong Ye, Ying Chen
Summary: The total burden of cerebral small vessel disease (CSVD) is closely related to cognitive impairment in Parkinson's disease (PD). CSVD burden and enlarged perivascular spaces are independent risk factors for cognitive impairment in PD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Zhenjie Teng, Jing Feng, Qianqian Qi, Yanhong Dong, Yining Xiao, Xiaohua Xie, Nan Meng, Huifang Chen, Wenhui Zhang, Peiyuan Lv
Summary: The study suggests that long-term use of metformin is associated with reduced risk of cognitive impairment and total CSVD burden score in patients with T2D.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hugh S. Markus, Frank Erik de Leeuw
Summary: Cerebral small vessel disease (SVD) is the main cause of lacunar stroke and intracerebral hemorrhage, and it is also the most common pathology underlying vascular cognitive impairment. This article reviews the advances in diagnosis, imaging, clinical presentations, pathogenesis, and treatment of SVD.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Olivia K. L. Hamilton, Ellen V. Backhouse, Esther Janssen, Angela C. C. Jochems, Caragh Maher, Tuula E. Ritakari, Anna J. Stevenson, Lihua Xia, Ian J. Deary, Joanna M. Wardlaw
Summary: This paper proposes an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD) and suggests the use of comprehensive cognitive assessments and the measurement of educational level in clinics and research settings. The study indicates that SVD affects all major domains of cognitive ability and low levels of education could be a modifiable risk factor for SVD-related cognitive impairment.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Fennie Choy Chin Wong, Chathuri Yatawara, Audrey Low, Heidi Foo, Benjamin Yi Xin Wong, Levinia Lim, Brian Wang, Dilip Kumar, Kok Pin Ng, Nagaendran Kandiah
Summary: The investigation revealed that hippocampal subfield atrophy worsened with increasing severity of small vessel disease. Positive SVD-HSA was characterized by significant atrophy in specific subfields, with greater atrophy seen in moderate to severe SVD compared to mild SVD. Atrophy in these subfields of SVD-HSA was significantly associated with poor episodic memory and frontal executive function.
TRANSLATIONAL STROKE RESEARCH
(2021)
Review
Neurosciences
Qin Yang, Xiaobo Wei, Bin Deng, Zihan Chang, Dana Jin, Yonghua Huang, John H. Zhang, Midori A. Yenari, Kunlin Jin, Qing Wang
Summary: Growing evidence suggests a significant association between altered neurovascular unit functioning and the pathophysiology of vascular cognitive impairment (VCI) caused by cerebral small vessel disease (CSVD). NVU dysregulation may lead to the entry of pathogens from the blood into the cerebral parenchyma by altering the blood-brain barrier (BBB), resulting in VCI. Additionally, the coupling of neural activity with cerebral blood flow and the clearance of metabolic byproducts may also be affected by NVU dysregulation.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Wenshan Sun, Lili Huang, Yue Cheng, Ruomeng Qin, Hengheng Xu, Pengfei Shao, Junyi Ma, Zhelv Yao, Lin Shi, Yun Xu
Summary: This study used AccuBrain (TM) to identify major CSVD-related brain changes and verified the relationship between brain atrophy and different cognition domains in CSVD patients. The results showed that MTA was related to cognition impairment in CSVD patients and might become a potential imaging marker for CSVD-CI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Zhenjie Teng, Jing Feng, Ronghui Liu, Yifan Ji, Jing Xu, Xin Jiang, Huifang Chen, Yanhong Dong, Nan Meng, Yining Xiao, Xiaohua Xie, Peiyuan Lv
Summary: This retrospective study investigated the association between serum total homocysteine (tHcy) levels and cerebral small vessel disease (CSVD) as well as cognitive function. The results showed that elevated serum tHcy levels were associated with cognitive impairment and the development of CSVD. The presence of different imaging markers of CSVD, especially the severe CSVD burden score, partially mediated the association between elevated serum tHcy levels and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Zhenjie Teng, Jing Feng, Peiyuan Lv
Summary: This study found an association between subclinical hypothyroidism (SCH) and cognitive function in patients with cerebral small vessel disease (CSVD). After adjusting for potential confounding factors, SCH was identified as an independent risk factor for cognitive impairment in CSVD patients (OR: 1.939, 95% CI: 1.170-3.213, P=0.010), and was also associated with severe CSVD burden (OR: 1.668, 95% CI: 1.085-2.564, P=0.020). Mediation analysis revealed that severe CSVD burden played a moderating role in the relationship between SCH and cognitive impairment (P=0.021), with 30.1% of the total effect attributable to the presence of severe CSVD burden. These findings suggest that screening for SCH in CSVD patients may help identify the risk of cognitive impairment.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Immunology
Tingting Wang, Aoming Jin, Ying Fu, Zaiqiang Zhang, Shaowu Li, David Wang, Yilong Wang
Summary: In cognitively impaired patients with CSVD, the heterogeneity of WMH may be related to conventional imaging features and injury of penetrating arteries, serving as a hallmark for early identification and prevention of cognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Emilia Salvadori, Michela Brambilla, Giorgia Maestri, Alessia Nicotra, Ilaria Cova, Simone Pomati, Leonardo Pantoni
Summary: There is no consensus on which test is more suitable for assessing cognitive deficits in cerebral small vessel disease (cSVD) patients. A meta-analysis of 86 studies was conducted to explore the ability of eight cognitive tests commonly used in this population to differentiate cSVD patients, controls, and other dementing conditions. The results showed that cSVD patients performed worse than healthy controls in all tests, but data on the comparison to neurodegenerative diseases were limited. There is currently incomplete evidence that a single test could differentiate cSVD patients with cognitive decline from other dementing diseases. Preliminary proposals were made to gain information about the clinical definition of cSVD, which currently remains based on neuroimaging.
ALZHEIMERS & DEMENTIA
(2023)
