期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 93, 期 1, 页码 E25-E28出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2011.03.009
关键词
Atorvastatin; Gemfibrozil; Inflammation markers; C-reactive protein; Phospholipase A2
资金
- Catalonian Research Board [1999 FI-712]
- Ministerio de Sanidad/ISCIII/FIS [C03/08, PI052099, PI051540, CP040110, CP060220]
- Pfizer
- Ministerio de Educacion y Ciencia [AP2004-1468]
A randomized, crossover study compared the effects of atorvastatin, gemfibrozil and their combination on inflammatory markers in type 2 diabetes. C-reactive protein (CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), secretory phospholipase A2 (sPLA2), interleukin 8 (IL8), monocyte chemotactic protein 1 (MCP1) and tumor necrosis factor alpha (TNF alpha) were measured. Both lipid-lowering drugs had positive, complementary and additive effects on inflammatory markers, which were closely related to baseline inflammatory status. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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