Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency

The 'A1' genetic variant of P-casein in milk has been linked to type I diabetes (T1D). The keystone piece of supporting evidence is an ecological study positively correlating the incidence of T1D with amount of A1 beta-casein consumption per capita. of relevance, A1 P-casein consumption is also positively correlated with latitude, itself implicated in T1D through vitamin D deficiency. Ecological and biological evidence convincingly implicate vitamin D deficiency in T1D. Latitude is a confounder of the ecological data that underpin the hypothesis that A1 beta-casein in cow's milk is a causative factor in T1D. (C) 2008 Elsevier Ireland Ltd. All rights reserved.