Article
Urology & Nephrology
Stefano Ciardullo, Cinzia Ballabeni, Roberto Trevisan, Gianluca Perseghin
Summary: This study suggests that metabolic syndrome, rather than obesity, is associated with kidney damage, and that patients with metabolic syndrome but without obesity may not have an increased risk of kidney disease.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Richard Anderson, Anchal Agarwal, Arnab Ghosh, Bo-Jhih Guan, Jackson Casteel, Nina Dvorina, William M. Baldwin, Barsanjit Mazumder, Taras Y. Nazarko, William C. Merrick, David A. Buchner, Maria Hatzoglou, Roman Kondratov, Anton A. Komar
Summary: eIF2A plays a crucial role in cellular development and stress response, and its knockout results in reduced lifespan, disrupted lipid homeostasis, decreased abundance of immune cells, and potentially affects sex-specific pathways. The identification of eIF2A function in the development of metabolic syndrome holds promise for further insights into specific eIF2A targets responsible for these changes.
Article
Cell Biology
Meng Ren, Lili You, Diaozhu Lin, Qiling Feng, Chulin Huang, Feng Li, Yiqin Qi, Wanting Feng, Chuan Yang, Li Yan, Kan Sun
Summary: The study showed that metabolic syndrome is associated with an increased incidence of low-grade albuminuria and CKD in middle-aged and elderly Chinese populations. The risk of developing these conditions also increased with the number of metabolic syndrome components present.
Article
Endocrinology & Metabolism
Qin Zhang, Wen-mu Hu, Yu-ling Deng, Jin-jing Wan, Yu-jun Wang, Ping Jin
Summary: This study found that gut microbiota dysbiosis and decreased propionic acid levels were observed in patients with Cushing's syndrome, which may be one of the causes of metabolic abnormalities. Therefore, the gut microbiota may serve as a potential therapeutic target to improve hypercortisolism-related metabolic abnormalities.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Lanhua Wang, Ling Jin, Wei Wang, Xia Gong, Yuting Li, Wangting Li, Xiaoling Liang, Wenyong Huang, Yizhi Liu
Summary: There is a strong association between renal function and vision-threatening diabetic retinopathy (VTDR) and diabetic macular oedema (DMO) in diabetic patients. The association between glomerular filtration rate (GFR) and VTDR is significant, while the association with any DR depends on the presence of microalbuminuria. High microalbuminuria and chronic kidney disease (CKD) are significantly associated with DMO.
Article
Medicine, General & Internal
Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
Summary: Active control of metabolic syndrome (MetS) can reduce the risk of colorectal cancer (CRC). Individuals who recover from MetS have a lower risk of CRC compared to those with persistent MetS. Resolving high blood pressure, abdominal obesity, and blood sugar levels can prevent CRC, while normalizing lipid profile does not independently decrease CRC risk. Therefore, controlling MetS is crucial for CRC prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xinru Guo, Shuang Liang, Wenling Wang, Ying Zheng, Chun Zhang, Xiangmei Chen, Guangyan Cai
Summary: This study found that LNSBP is associated with heavy proteinuria and kidney disease outcomes in elderly CKD patients, highlighting its potential value in guiding antihypertensive treatment to improve renal prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Erikka W. Bystad, Vidar T. N. Stefansson, Bjorn O. Eriksen, Toralf Melsom
Summary: MetS is associated with hyperfiltration and steeper long-term GFR decline in the non-diabetic general population.
KIDNEY INTERNATIONAL REPORTS
(2023)
Letter
Medicine, General & Internal
Carl P. Walther, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Summary: This cross-sectional study explores the changes in chronic kidney disease (CKD) severity and associated complications in the US population, using two equations for estimating glomerular filtration rate (GFR) from 2021 and 2009 respectively.
Article
Nutrition & Dietetics
Jorge Subias-Perie, David Navarrete-Villanueva, Angel Ivan Fernandez-Garcia, Ana Moradell, Eva Gesteiro, Jorge Perez-Gomez, Ignacio Ara, German Vicente-Rodriguez, Jose Antonio Casajus, Alba Gomez-Cabello
Summary: Metabolic syndrome has a high prevalence in Spanish older adults, but varies with different definitions. Sex and frailty do not appear to influence the development of MetS. However, physical activity seems to decrease the risk of central obesity, hypertension, and developing MetS.
Article
Health Care Sciences & Services
Li-Wei Chen, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien
Summary: This study conducted a longitudinal community-based prospective study on the impact of H. pylori infection on metabolic parameters, finding that HBA1c was associated with new H. pylori infection and BMI was linked to H. pylori loss. Serial analyses within group 3 revealed increased HBA1c and HDL values, but decreased cholesterol and WBC values associated with H. pylori infection loss.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jiaqi Sun, Jun Ding, Qingsong Shen, Xiyang Wang, Min Wang, Yongping Huang, Xuechun Zhang, Huan Zhu, Feng Zhang, Dongde Wu, Min Peng, Zhonglin Zhang, Yufeng Yuan, Wenhua Li, Zhi-Gang She, Xiao-Jing Zhang, Hongliang Li, Peng Zhang, Zan Huang
Summary: This study reveals the involvement of propionyl-CoA (Pro-CoA) metabolism in hepatocellular carcinoma (HCC) and its impact on HCC proliferation and energy metabolism. ALDH6A1-mediated Pro-CoA metabolism suppresses HCC proliferation by impairing energy metabolism. The metabolites derived from Pro-CoA metabolism serve as potential metabolic biomarkers for HCC diagnosis and treatment.
JOURNAL OF HEPATOLOGY
(2023)
Letter
Medicine, General & Internal
Marc Raynaud, Olivier Aubert, Alexandre Loupy
Summary: This letter evaluates a new calculation formula for estimating glomerular filtration rate without considering race. The authors point out that the accuracy of the formula has not been confirmed in diverse subpopulations or countries.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pediatrics
Lauren N. Lopez, Weijie Wang, Lindsey Loomba, Maryam Afkarian, Lavjay Butani
Summary: Diabetic kidney disease is increasingly affecting children due to the rising obesity epidemic and type 2 diabetes. New therapeutic approaches like GLP1 receptor agonists and SGLT2 inhibitors show promising effects on cardiorenal outcomes.
PEDIATRIC NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)