Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β-cell line

Aim Glucokinase (GK) in pancreatic beta cells is thought to be involved in insulin secretion and glucose homeostasis. This study investigates whether the long-acting agonist of the glucagon-like peptide 1, namely exendin-4, mediates stimulatory effects on GK gene expression through the Ca