Article
Microbiology
Frank Petrak, Stephan Herpertz, Julia Hirsch, Bonnie Roehrig, Iris Donati-Hirsch, Georg Juckel, Juris J. Meier, Soeren Gatermann
Summary: This study compared the gut microbiome composition between individuals with type 1 diabetes and depression, individuals with type 1 diabetes without depression, and healthy controls. The results showed that individuals with type 1 diabetes and comorbid depression had a higher abundance of Megasphaera in their gut, suggesting a possible involvement of bacterial groups in depression in people with diabetes.
Article
Medicine, Research & Experimental
Cristina Ma Diaz-Perdigones, Araceli Munoz-Garach, Maria Dolores Alvarez-Bermudez, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that patients with early intolerance to metformin had higher levels of Subdoligranulum in the gut microbiome, while Veillonella and Serratia were higher in the non-tolerant group. The tolerant group showed enrichment of Megamonas, Megamonas rupellensis, and Phascolarctobacterium spp, with lower levels of Ruminococcus gnavus in the longitudinal analysis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Sergio Perez-Burillo, Daniel Hinojosa-Nogueira, Beatriz Navajas-Porras, Telmo Blasco, Francesco Balzerani, Alberto Lerma-Aguilera, Daniel Leon, Silvia Pastoriza, Inigo Apaolaza, Francisco J. Planes, Maria Pilar Francino, Jose Angel Rufian-Henares
Summary: The freezing of fecal material does not significantly alter the functionality of the microbial communities, as potential functionality remains preserved due to functional redundancy. Though the microbial community structure may differ slightly between fresh and frozen samples, the variation introduced by freezing is minimal compared to the variation among individuals. The most affected genus by freezing is Bacteroides, a fiber degrading bacteria.
Review
Nutrition & Dietetics
Emily A. Losno, Katharina Sieferle, Federico J. Armando Perez-Cueto, Christian Ritz
Summary: The human gut microbiota play a crucial role in health and are influenced by dietary habits. Vegan diets may impact the diverse ecosystem of beneficial bacteria in the gut. Studies on vegans suggest changes in gut microbiota composition, but complexities in evaluating results and the need for more randomized controlled trials are highlighted.
Article
Food Science & Technology
Eun-Ji Song, Min Jung Kim, Chang Hwa Jung, Won-Hyong Chung, Young-Do Nam, Mi Young Lim
Summary: This study aimed to investigate the effect of the traditional fermented soybean food Cheonggukjang on gut microbial composition and isoflavone metabolites in healthy Korean individuals. The results showed that the gut microbial composition was associated with the changes in the gut microbiota and isoflavone-metabolite profiles after CKJ supplementation. This highlights the importance of personalized nutrition guidance based on an individual's gut microbial composition.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Gastroenterology & Hepatology
Claudia Herrera-deGuise, Encarna Varela, Guillaume Sarrabayrouse, Marta Pozuelo del Rio, Virginia Robles Alonso, Natalia Borruel Sainz, Francesc Casellas, Luis Fernando Mayorga, Chaysavanh Manichanh, Fernando Azpiroz Vidaur, Francisco Guarner
Summary: The gut microbial ecosystem in ulcerative colitis (UC) patients with long-term remission shows similarities to healthy individuals. Patients with short-term remission or disease flare exhibit reduced diversity and richness of gut microbiota, as well as an increase in potentially harmful bacteria. Patients in long-term remission have a composition of fecal bacteria similar to healthy controls, and the presence of A. muciniphila in fecal samples predicts flare-free outcomes.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Plant Sciences
Tong Xu, Yiman Ge, Huan Du, Qi Li, Xinmei Xu, Huan Yi, Xinyue Wu, Tingting Kuang, Gang Fan, Yi Zhang
Summary: The study revealed that BK extract has a significant anti-diabetic effect on T2D rats by regulating gut microbiota.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Microbiology
Daria A. Kashtanova, Natalia S. Klimenko, Olga N. Tkacheva, Irina D. Strazhesko, Victoria A. Metelskaya, Natalia V. Gomyranova, Sergey A. Boytsov
Summary: The study revealed a positive association between high gut microbiota diversity and healthy metabolic markers (such as HDL-cholesterol level), while low gut microbiota diversity was negatively associated with conditions such as obesity and dyslipidemia.
Article
Immunology
Cristian Morales, Gabriel Rojas, Camilo Rebolledo, Marcelo Rojas-Herrera, Raul Arias-Carrasco, Sara Cuadros-Orellana, Vinicius Maracaja-Coutinho, Kathleen Saavedra, Pamela Leal, Fernando Lanas, Luis A. Salazar, Nicolas Saavedra
Summary: Our study revealed significant differences in weight, height, BMI, and serum lipid levels between hypercholesterolemic individuals and controls. LEfSe analysis identified differentially abundant prokaryotic taxa in the two groups. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2) showed different predominant metabolic pathways between the two groups.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Haim Leibovitzh, Sun-Ho Lee, Mingyue Xue, Juan Antonio Raygoza Garay, Cristian Hernandez-Rocha, Karen L. Madsen, Jonathan B. Meddings, David S. Guttman, Osvaldo Espin-Garcia, Michelle Smith, Ashleigh Goethel, Anne M. Griffiths, Paul Moayyedi, A. Hillary Steinhart, Remo Panaccione, Hien Q. Huynh, Kevan Jacobson, Guy Aumais, David R. Mack, Maria T. Abreu, Charles N. Bernstein, John K. Marshall, Dan Turner, Wei Xu, Williams Turpin, Kenneth Croitoru
Summary: This study found that alterations in gut microbial composition and functional pathways are associated with changes in gut barrier function. These findings may identify potential microbial targets to modulate gut barrier.
Article
Integrative & Complementary Medicine
Sutianzi Huang, Li Shao, Manyun Chen, Lin Wang, Jing Liu, Wei Zhang, Weihua Huang
Summary: This study found significant differences in the gut microbiota's biotransformation of GCK between diabetic patients and healthy subjects, with the gut microbiota of diabetic patients metabolizing GCK slower. This difference in biotransformation capacity may impact the anti-diabetic potency of GCK.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Gastroenterology & Hepatology
S. Coughlan, A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: The study conducted metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. It found significantly lower alpha diversity of viral clusters in IBS, identified core viromes in both IBS and control groups, and noted no significant covariation between the virome and the bacteriome, IBS clinical subtype, or Bile Acid Malabsorption status.
Article
Medicine, General & Internal
Barbara Zapala, Tomasz Stefura, Magdalena Wojcik-Pedziwiatr, Radoslaw Kabut, Marta Balajewicz-Nowak, Tomasz Milewicz, Alicja Dudek, Anastazja Stoj, Monika Rudzinska-Bar
Summary: The study compared the gut microbiota composition between patients diagnosed with Parkinson's disease and those treated only with Levodopa to healthy controls, finding that PD patients have significantly different gut microbiota profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Armin Rashidi, Maryam Ebadi, Daniel J. Weisdorf, Massimo Costalonga, Christopher Staley
Summary: The study revealed that microbial communities in the mouth and distal gut are completely distinct, with no evidence of oral bacteria colonizing the gut. Finding the same bacteria in the mouth and stool may indicate the need for further clinical investigation for underlying pathologies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Andrea G. Izquierdo, Hatim Boughanem, Angel Diaz-Lagares, Isabel Arranz-Salas, Manel Esteller, Francisco J. Tinahones, Felipe F. Casanueva, Manuel Macias-Gonzalez, Ana B. Crujeiras
Summary: The study identified specific epigenetic marks in visceral adipose tissue associated with colorectal cancer, potentially providing useful tools for prediction and personalized treatment of CRC.
Article
Urology & Nephrology
Hiddo J. L. Heerspink, David Cherney, Douwe Postmus, Bergur Stefansson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, C. David Sjostrom, Robert D. Toto, David C. Wheeler
Summary: This analysis of DAPA-CKD found that dapagliflozin can reduce the risk of abrupt declines in kidney function in patients with CKD and substantial albuminuria.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Maria Molina-Vega, Maria J. Picon-Cesar, Carolina Gutierrez-Repiso, Andrea Fernandez-Valero, Fuensanta Lima-Rubio, Stella Gonzalez-Romero, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: In women with gestational diabetes mellitus, treatment with metformin led to lower postprandial glycemia and less weight gain compared to treatment with insulin. There were also changes in the composition of gut microbiota, with a decrease in Firmicutes and Peptostreptococcaceae abundance and an increase in Proteobacteria and Enterobacteriaceae abundance in the metformin group. Predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis were more prevalent in the metformin group. Further studies are needed to understand how these changes impact metabolic control during and after pregnancy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Surgery
Carolina Gutierrez-Repiso, Lourdes Garrido-Sanchez, Juan Alcaide-Torres, Isabel Cornejo-Pareja, Luis Ocana-Wilhelmi, Eduardo Garcia-Fuentes, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that the composition of the gut microbiota before surgery may impact the outcomes of bariatric surgery. The Prevotella-to-Bacteroides ratio could serve as a predictive tool for weight loss trajectory. Early after surgery, patients who experienced successful weight loss showed an enrichment in taxa related to beneficial effects on host metabolism.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Food Science & Technology
Jiaqi Ni, Stephanie K. Nishi, Nancy Babio, Miguel A. Martinez-Gonzalez, Dolores Corella, Olga Castaner, J. Alfredo Martinez, Angel M. Alonso-Gomez, Enrique Gomez-Gracia, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin-Sanchez, Xavier Pinto, Jose J. Gaforio, Ana Barabash Bustelo, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Estefania Toledo, Oscar Coltell, Carlos Gomez-Martinez, Maria Dolores Zomeno, Carolina Donat-Vargas, Leire Goicolea-Guemez, Cristina Bouzas, Manoli Garcia-de-la-Hera, Alice Chaplin, Antonio Garcia-Rios, Rosa Casas, Isabel Cornejo-Pareja, Jose Manuel Santos-Lozano, Teresa Rognoni, Carmen Saiz, Indira Paz-Ganiel, Mireia Malcampo, Almudena Sanchez-Villegas, Itziar Salaverria-Lete, Ana Garcia-Arellano, Helmut Schroeder, Jordi Salas-Salvado
Summary: This study found that older adults with higher consumption of total milk and whole-fat milk are more likely to experience a decline in cognitive function, while consumption of low-fat milk, yogurt, cheese or fermented dairy had no significant impact.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yuan-Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco Jose Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Summary: This study compared the effects of bexagliflozin tablets and glimepiride on the treatment of patients with type 2 diabetes. It was found that bexagliflozin tablets were noninferior to glimepiride in lowering HbA1c levels, and were superior in reducing body mass and systolic blood pressure. Additionally, bexagliflozin tablets were associated with fewer hypoglycemic events and had a favorable effect on estimated glomerular filtration rate (eGFR).
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Hatim Boughanem, Pallavi Kompella, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Gene expression can be regulated by epigenomic modifications such as DNA methylation, histone modification, and chromosome remodeling. Vitamins, as natural bioactive compounds, have been found to modify epigenetic patterns and potentially impact the risk of cancer, including colorectal cancer (CRC). This review examines the relationship between vitamins and CRC risk through epidemiological and observational studies and discusses the potential of using vitamins as epigenetic modifiers for CRC treatment. Although more studies with better designs are needed, understanding the molecular mechanisms of vitamin-mediated epigenetic regulation can help identify effective therapeutic targets for CRC prevention and treatment.
Article
Medicine, Research & Experimental
Aurora Laborda-Illanes, Lidia Sanchez-Alcoholado, Daniel Castellano-Castillo, Soukaina Boutriq, Isaac Plaza-Andrades, Lucia Aranega-Martin, Jesus Peralta-Linero, Emilio Alba, Alicia Gonzalez-Gonzalez, Maria Isabel Queipo-Ortuno
Summary: This study aimed to develop rapid, economic, high capacity, and easy handling angiogenesis assays to test the antiangiogenic effects of melatonin and determine its most effective dose to inhibit angiogenic sprouting induced by VEGF and MCF-7. The results demonstrated that melatonin had an inhibitory effect on angiogenesis, and this inhibition was dose-dependent.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Iris Reina-Perez, Francisco Artacho-Cordon, Vicente Mustieles, Daniel Castellano-Castillo, Fernando Cardona, Inmaculada Jimenez-Diaz, Jose A. Lopez-Medina, Juan Alcaide, Luis Ocana-Wilhelmi, Luz M. Iribarne-Duran, Juan P. Arrebola, Nicolas Olea, Francisco J. Tinahones, Mariana F. Fernandez
Summary: This study suggests that the accumulation of persistent organic pollutants (POPs) in visceral adipose tissue is associated with metabolic syndrome. The levels of certain organic pollutants in adipose tissue were found to be related to indicators of metabolic syndrome such as high blood sugar, high blood pressure, and waist circumference. The study also found that the mixture effect of various organic pollutants was associated with the occurrence of metabolic syndrome.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Natalia Mena-Vazquez, Patricia Ruiz-Limon, Isabel Moreno-Indias, Sara Manrique-Arija, Jose Manuel Lisbona-Montanez, Jose Rioja, Arkaitz Mucientes, Gracia Maria Martin-Nunez, Laura Cano-Garcia, Francisco J. Tinahones, Antonio Fernandez-Nebro
Summary: This study aimed to analyze the intestinal microbiota of patients with rheumatoid arthritis (RA) and obesity, as well as a higher percentage of fatty tissue. A nested case-control study of 80 RA patients and 80 age and sex-matched controls was conducted, and it was found that obesity was more frequent in RA patients and was associated with differences in gut microbiota. Certain bacterial genera were found to be associated with obesity and fat mass index (FMI) in RA patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Maria Angeles Nunez-Sanchez, Maria Antonia Martinez-Sanchez, Andres Balaguer-Roman, Virginia E. E. Fernandez-Ruiz, Mercedes Ferrer-Gomez, Tomasz Sledzinski, Maria Dolores Frutos, Jose Carlos Fernandez-Garcia, Adriana Mika, Bruno Ramos-Molina
Summary: In this study, the serum and hepatic levels of branched-chain fatty acids (BCFAs) were evaluated in patients with different stages of nonalcoholic fatty liver disease (NAFLD). The results showed an increase in hepatic BCFAs in NAFLD patients, but no differences were observed in serum BCFAs. Correlation analysis also revealed a relationship between hepatic BCFAs and histopathological diagnosis, as well as other parameters related to NAFLD. Gene expression analysis indicated an upregulation of BCAT1, BCAT2, and BCKDHA mRNA levels in NAFLD patients.
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Eva Galle, Chee-Wai Wong, Adhideb Ghosh, Thibaut Desgeorges, Kate Melrose, Laura C. Hinte, Daniel Castellano-Castillo, Magdalena Engl, Joao Agostinho de Sousa, Francisco Javier Ruiz-Ojeda, Katrien De Bock, Jonatan R. Ruiz, Ferdinand von Meyenn
Summary: This study generated genome-wide datasets of H3K18la and found that it marks both active promoters and tissue-specific active enhancers.
Meeting Abstract
Cardiac & Cardiovascular Systems
F. Cardona, D. Castellano-Castillo, B. Ramos-Molina, M. A. Martinez-Sanchez, M. D. Frutos-Bernal, M. I. Queipo-Ortuno