Review
Nutrition & Dietetics
Junxiang Miao, Yan Chen, Xiaoling Liu, Changxiang Ye, Xuan Zhou, Ziqi Yang, Ziqiang Gong, Lizhang Chen, Tingting Wang
Summary: This research conducted a systematic and comprehensive meta-analysis to determine the association between maternal body mass index (BMI) and gestational weight gain (GWG) and the risk of cancer in offspring. The results suggest that high GWG may increase the risk of total cancer in offspring, while low GWG is not associated with the risk. There is no significant association between maternal underweight, overweight/obesity, and the risk of total cancer in offspring. Further research is needed to clarify the potential relevance of maternal BMI and GWG on offspring cancer, especially for specific cancers.
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Public, Environmental & Occupational Health
Kara M. Whitaker, Rachel Ryan, Courtney Becker, Heather Healy
Summary: This systematic review included 29 studies and found that excessive gestational weight gain was associated with an increased risk of hypertensive disorders of pregnancy, while inadequate gestational weight gain was associated with lower birthweight, being small for gestational age, and preterm birth in twins. Though gestational weight gain within IOM guidelines appeared to lead to more optimal outcomes, further methodologically rigorous studies are needed to inform evidence-based guidelines.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Pediatrics
Jian Wang, Bowen Du, Yujian Wu, Zhuoyan Li, Qian Chen, Xi Zhang, Lin Zhang, Yujiao Ye, Yurong Wu, Sun Chen, Kun Sun
Summary: Excessive maternal gestational weight gain is associated with an increased risk of thickening of the interventricular septum in offspring, particularly during the second and third trimesters. Maternal weight gain in the second and third trimesters is a risk factor for left ventricle eccentric and concentric hypertrophy in offspring.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Gilberto Kac, Thais R. B. Carilho, Kathleen M. Rasmussen, Michael E. Reichenheim, Dayana R. Farias, Jennifer A. Hutcheon
Summary: Monitoring gestational weight gain is crucial for a successful pregnancy, and this study aimed to construct GWG charts for Brazilian women based on pre-pregnancy BMI. The charts offer insights into GWG patterns by gestational age and BMI, providing valuable information for monitoring and improving maternal and neonatal health outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Veronica Perea, Andreu Simo-Servat, Carmen Quiros, Nuria Alonso-Carril, Maite Valverde, Xavier Urquizu, Antonio J. Amor, Eva Lopez, Maria-Jose Barahona
Summary: This study found that pregestational obesity is associated with a higher risk of ADHD in offspring of GDM pregnancies. However, excessive weight gain during pregnancy does not have an independent effect on ADHD risk. Only the joint association of obesity and excessive weight gain during pregnancy remains significant in relation to ADHD risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Bing-Kun Zheng, Xue-Yi Sun, Jie Xian, Peng-Peng Niu
Summary: This two-sample Mendelian randomization study found an inverse relationship between maternal testosterone levels and offspring birth weight, as well as an increased risk of preterm delivery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Renata Saucedo, Maria Isabel Pena-Cano, Mary Flor Diaz-Velazquez, Aldo Ferreira-Hermosillo, Juan Mario Solis-Paredes, Ignacio Camacho-Arroyo, Jorge Valencia-Ortega
Summary: This study found that excessive and adequate gestational weight gain (GWG) were associated with higher expressions of inflammatory genes in visceral adipose tissue (VAT) compared to insufficient GWG. Additionally, GWG was positively correlated with newborn weight.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
P. M. Y. Lee, L. A. Tse, K. D. Laszlo, D. Wei, Y. Yu, J. Li
Summary: The study found an association between maternal gestational weight gain and offspring's intellectual developmental disorders, which may be modified by maternal early-pregnancy BMI.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Yuexin Gan, Donghao Lu, Chonghuai Yan, Jun Zhang, Jian Zhao
Summary: This study used Mendelian randomization to investigate the causal effect of maternal PCOS on offspring birth weight, and found little evidence to support a significant impact of maternal PCOS on offspring weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Penny Lam, Brendan J. Mein, Ronald J. Benzie, John T. Ormerod, Kristy P. Robledo, Emily J. Hibbert, Ralph K. Nanan
Summary: This study analyzed the effects of maternal diabetes mellitus and body mass index on central and peripheral fat accrual in large for gestational age offspring. The results showed that diabetes mellitus was associated with increased abdominal and mid-thigh fat accumulation in fetuses, independent of BMI.
Article
Obstetrics & Gynecology
Rachel K. Harrison, Vishmayaa Saravanan, Caroline Davitt, Meredith Cruz, Anna Palatnik
Summary: The prevalence of hypoglycemia in pregnant women after pharmacotherapy for gestational diabetes mellitus (GDMA2) was 19.4%, with glyburide being the most common drug associated. Newborns exposed to maternal hypoglycemia had higher rates of adverse neonatal outcomes.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Lixia Lin, Xi Chen, Li Huang, Chunrong Zhong, Meng Wu, Weiming Wang, Huanzhuo Wang, Sen Yang, Xiyu Cao, Guoping Xiong, Xuefeng Yang, Liping Hao, Guoqiang Sun, Nianhong Yang
Summary: A prospective cohort study in Wuhan, China found that rapid gestational weight gain (GWG) in early pregnancy was associated with a lower risk of allergic diseases in offspring.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Nutrition & Dietetics
Thais Rangel Bousquet Carrilho, Jennifer A. Hutcheon, Kathleen M. Rasmussen, Michael E. Reichenheim, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Gilberto Kac
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) associated with the lowest risks of adverse maternal and infant outcomes using Brazilian GWG charts. The findings showed that GWG z-scores were associated with large-for-gestational-age (LGA) and small-for-gestational-age (SGA) births, indicating the importance of GWG range in affecting maternal and neonatal outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Lene Ringholm, Nicoline Callesen Do, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: This study evaluated pregnancy outcomes in pregnant women with type 1 diabetes using degludec, an ultra-long-acting insulin analog, compared to other long-acting insulin analogs. The results showed that degludec had similar pregnancy outcomes as other long-acting insulin analogs in a real-world setting, suggesting that degludec can be continued throughout pregnancy.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Martin Overgaard, Tina Ravnsborg, Zuzana Lohse, Birgitte Bytoft, Tine D. Clausen, Rikke B. Jensen, Peter Damm, Kurt Hojlund, Claus H. Gravholt, Sine Knorr, Dorte M. Jensen
Summary: Exposure to maternal type 1 diabetes during pregnancy has sex-specific effects on offspring, impacting serum levels of proteins involved in lipid, metabolic and transport processes. Low levels of Apolipoprotein D may serve as an early risk marker for metabolic syndrome. Further investigation is needed to explore the potential link between Apolipoprotein D and cardiovascular disease.
Review
Endocrinology & Metabolism
Gernot Desoye, Lene Ringholm, Peter Damm, Elisabeth R. Mathiesen, Mireille N. M. van Poppel
Summary: Despite progress in blood glucose control, pregnancy in women with type 1 diabetes still poses risks for the fetus. Good glycemic control reduces the risk of fetal overgrowth, but hyperglycemia can still lead to fetal overnutrition and adiposity. Preventing fetal adiposity requires revised goal setting and continuous glucose monitoring.
Editorial Material
Endocrinology & Metabolism
Mireille N. M. van Poppel, Peter Damm, Elisabeth R. R. Mathiesen, Lene Ringholm, Cuilin Zhang, Gernot Desoye
Summary: In pregnancies of women with obesity or diabetes, neonates are often overgrown. This article focuses on possible growth deviations earlier in pregnancy and their potential contribution to neonatal overgrowth, suggesting that early-pregnancy growth reduction followed by in utero catch-up growth may confer a higher risk of obesity in later life.
Review
Endocrinology & Metabolism
Katrien Benhalima, Kaat Beunen, Sarah E. Siegelaar, Rebecca Painter, Helen R. Murphy, Denice S. Feig, Lois E. Donovan, Sarit Polsky, Elizabeth Buschur, Carol J. Levy, Yogish C. Kudva, Tadej Battelino, Lene Ringholm, Elisabeth R. Mathiesen, Chantal Mathieu
Summary: Maintaining glucose concentrations within target, appropriate gestational weight gain, lifestyle management, and using antihypertensive treatment and low-dose aspirin if necessary can reduce the risk of complications in pregnancies complicated by type 1 diabetes. Hybrid closed-loop insulin delivery systems show promise as a treatment option during pregnancy.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Emma Davidsen, Helle Terkildsen Maindal, Molly Byrne, Louise Kelstrup, Per Ovesen, Peter Damm, Karoline Kragelund Nielsen
Summary: The aim of this study was to examine the perceptions of women with gestational diabetes mellitus (GDM) in Denmark, focusing on GDM-specific stigma. Through semi-structured interviews and analysis, five themes were identified including victim-blaming narrative, identity threat, non-disclosure and anticipated stigma, stigma in a clinical setting, and stigma reduction in a clinical setting. The study also found intersectionality between GDM-specific stigma, notions of being a good mother, and stigma associated with type 2 diabetes mellitus and overweight. GDM-specific stigma had implications for GDM care and management, such as not attending GDM screening and not wanting to disclose the diagnosis.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Maja Thogersen, Karoline Kragelund Nielsen, Rasmus Wibaek, Peter Damm, Rikke Beck Jensen, Helene Nielsen, Helle Terkildsen Maindal, Gregers Stig Andersen
Summary: This study aimed to analyze the body mass index (BMI) trajectories of children exposed to gestational diabetes mellitus (GDM) from birth to 10 years old and associate them with infant and maternal characteristics. The study identified three distinct BMI trajectories for children exposed to GDM, which were normal, late accelerating, and early accelerating. These BMI trajectories were associated with infant and maternal characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sidse K. Norgaard, Julie C. Soholm, Elisabeth R. Mathiesen, Kirsten Norgaard, Tine D. Clausen, Pernille Holmager, Nicoline C. Do, Peter Damm, Lene Ringholm
Summary: The study found that using faster aspart compared to insulin aspart in pregnant women with diabetes did not pose additional safety issues, and resulted in similar effects on fetal growth and maternal indicators.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Sidse Kjaerhus Norgaard, Peter Damm, Elisabeth R. Mathiesen, Lene Ringholm
Summary: Women with type 1 or type 2 diabetes are more likely to develop preeclampsia. Blood pressure monitoring, physical activity, and prophylactic aspirin may help decrease the prevalence of preeclampsia in women with preexisting diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Nanna Husted Jensen, Karoline Kragelund Nielsen, Inger Katrine Dahl-Petersen, Ulla Kampmann, Peter Damm, Per Ovesen, Elisabeth Reinhardt Mathiesen, Christina Anne Vinter, Emma Davidsen, Maja Thogersen, Anne Timm, Lise Lotte Torvin Andersen, Sine Knorr, Dorte Moller Jensen, Helle Terkildsen Maindal
Summary: The Face-it trial is a randomized controlled trial for women with recent gestational diabetes mellitus (GDM) and their families. The penetration and participation rates were acceptable, with participating women showing slight differences in characteristics based on partner participation status.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
Cathrine Munk Scheuer, Dorte Moller Jensen, H. David McIntyre, Lene Ringholm, Elisabeth Reinhardt Mathiesen, Celina Pforr Korsgard Nielsen, Runa Louise Mortansdottir Nolsoe, Julie Milbak, Thore Hillig, Peter Damm, Martin Overgaard, Tine Dalsgaard Clausen
Summary: This study aims to compare the prevalence of gestational diabetes mellitus (GDM) in a Danish cohort using the current Danish criteria and the WHO2013 criteria, and evaluate the adverse pregnancy outcomes among untreated women who fall between the diagnostic thresholds. The results showed a significantly higher GDM prevalence when using the WHO2013 criteria compared to the Danish criteria, and untreated GDM in the gap between the two criteria resulted in higher risks of adverse pregnancy outcomes.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Endocrinology & Metabolism
S. Norgaard, J. Soholm, E. Mathiesen, K. Norgaard, T. Clausen, P. Holmager, N. Do, P. Damm, L. Ringholm
Meeting Abstract
Endocrinology & Metabolism
J. C. Soholm, S. K. Norgaard, N. C. Do, K. Norgaard, T. D. Clausen, P. Damm, E. R. Mathiesen, L. Ringholm
Letter
Endocrinology & Metabolism
Lene Ringholm, Nicoline Callesen Do, Peter Damm, Elisabeth Reinhardt Mathiesen
ACTA DIABETOLOGICA
(2023)