Article
Medicine, Research & Experimental
Jinsook Son, Hongxu Ding, Thomas B. Farb, Alexander M. Efanov, Jiajun Sun, Julie L. Core, Samreen K. Syed, Zhigang Lei, Qidi Wang, Domenico Accili, Andrea Califano
Summary: This study identified T2D-specific subpopulations characterized by metabolic inflexibility and endocrine progenitor/stem cell features, with BACH2 identified as a key driver of T2D cell states. BACH2 knockout in T2D islets reversed cellular features of the disease. Treatment with a BACH inhibitor showed potential for pharmacological intervention in diabetic mice and human islets.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Ioannis N. Petropoulos, Georgios Ponirakis, Uazman Alam, Omar Asghar, Andrew Marshall, Catherine Fullwood, Maria Jeziorska, Caroline Abbott, Giuseppe Lauria, Catharina G. Faber, Handrean Soran, Nathan Efron, Andrew J. M. Boulton, Rayaz A. Malik
Summary: Corneal confocal microscopy (CCM) has shown to be more effective in identifying severe corneal nerve loss in patients with type 1 diabetes compared to type 2 diabetes. It also demonstrates good diagnostic accuracy for diabetic peripheral neuropathy (DPN). Furthermore, the risk factors for a reduction in corneal nerve fiber length differ between type 1 and type 2 diabetes.
Article
Endocrinology & Metabolism
Mary Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: This study found that a history of gestational diabetes mellitus, whether occurring once or multiple times, significantly increases the risk of developing type 2 diabetes. The risk increases steeply with each additional affected pregnancy, and although it attenuates over time after the affected pregnancies, it remains elevated for >35 years.
Article
Endocrinology & Metabolism
Mary V. Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: Gestational diabetes mellitus is strongly associated with an increased risk of type 2 diabetes, and this risk persists for over 35 years. The risk of type 2 diabetes is higher with each additional pregnancy affected by gestational diabetes mellitus, and the association weakens over time.
Article
Endocrinology & Metabolism
Liran Hiersch, Baiju R. Shah, Howard Berger, Michael Geary, Sarah D. McDonald, Beth Murray-Davis, Ilana Halperin, Ravi Retnakaran, Jon Barrett, Nir Melamed
Summary: This study aimed to quantify the risk of future maternal type 2 diabetes mellitus (T2DM) in women with gestational diabetes mellitus (GDM) based on the type and number of abnormal values in the 75-g oral glucose tolerance test (OGTT) and the diagnostic criteria used for GDM diagnosis. The risk of future T2DM was significantly higher in women with GDM, especially when using the Diabetes Canada criteria compared to the International Association of the Diabetes and Pregnancy Study Groups criteria. Individualized risk assessment for future T2DM can be provided based on the type and number of abnormal OGTT values in women with GDM.
Article
Endocrinology & Metabolism
Yan Chen, Qianrong Wang, Zhiguo Xie, Gan Huang, Li Fan, Xia Li, Zhiguang Zhou
Summary: The aim of this study was to investigate the impact of family history of type 2 diabetes (T2D) on the clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). The results showed that idiopathic T1D patients with a family history of T2D were more likely to have features associated with T2D and better beta-cell function. The impact of T2D family history was consistently observed in idiopathic T1D patients regardless of HLA genotypes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Environmental Sciences
Onil Banerjee, Martin Cicowiez, Marcia N. Macedo, Ziga Malek, Peter H. Verburg, Sean Goodwin, Renato Vargas, Ludmila Rattis, Kenneth J. Bagstad, Paulo M. Brando, Michael T. Coe, Christopher Neill, Octavio Damiani Marti, Josue Avila Murillo
Summary: The Amazon biome is approaching an ecological tipping point, and policy interventions can prevent further losses and bring significant economic benefits.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Endocrinology & Metabolism
Anna Parkkola, Maaret Turtinen, Taina Harkonen, Jorma Ilonen, Mikael Knip
Summary: Family history of type 2 diabetes may impact the phenotype and genotype of children with type 1 diabetes, as children with a positive family history for type 2 diabetes tend to have features associated with type 2 diabetes at the time of type 1 diabetes diagnosis.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Multidisciplinary Sciences
Jiyu Sun, Gyu Ri Kim, Su Jin Lee, Hyeon Chang Kim
Summary: Recent studies have shown an association between gestational diabetes mellitus (GDM) and increased risk for future cardiovascular disease. The progression of GDM to type 2 diabetes (T2DM) is linked with a higher risk of cardiovascular diseases, highlighting the importance of postpartum diabetes screening and interventions in women with a history of GDM to reduce future CVD risk.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Francesco Liguori, Elisa Mascolo, Fiammetta Verni
Summary: Diabetes mellitus is a heterogeneous disease characterized by high blood sugar caused by a combination of genetic and environmental factors, with both monogenic and multigenic forms. While many putative causative genes have been identified, a large percentage of cases remain undiagnosed, indicating a need for further research to identify causal variants of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Clinical Neurology
Melanie Annoussamy, Andreea M. Seferian, Aurore Daron, Yann Pereon, Claude Cances, Carole Vuillerot, Liesbeth De Waele, Vincent Laugel, Ulrike Schara, Teresa Gidaro, Charlotte Lilien, Jean-Yves Hogrel, Pierre Carlier, Emmanuel Fournier, Linda Lowes, Ksenija Gorni, Myriam Ly-Le Moal, Nicole Hellbach, Timothy Seabrook, Christian Czech, Ricardo Hermosilla, Laurent Servais
Summary: The study characterized the natural history of SMA over 24 months using innovative measures such as wearable devices, demonstrating that MFM32, MyoGrip, MyoPinch, and ActiMyo(R) could detect a significant decline in patients with Type 2 and 3 SMA over 12 or 24 months.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Jinbo Hu, Yang Hu, Ellen Hertzmark, Chen Yuan, Gang Liu, Meir J. Stampfer, Eric B. Rimm, Frank B. Hu, Molin Wang, Qi Sun
Summary: This study found a significant association between substantial weight loss and increased mortality among newly diagnosed type 2 diabetes patients, which was abolished by improving lifestyle quality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Georgia Stimpson, Danielle Ramsey, Amy Wolfe, Anna Mayhew, Mariacristina Scoto, Giovanni Baranello, Robert Muni Lofra, Marion Main, Evelin Milev, Giorgia Coratti, Marika Pane, Valeria Sansone, Adele D'Amico, Enrico Bertini, Sonia Messina, Claudio Bruno, Emilio Albamonte, Elena Stacy Mazzone, Jacqueline Montes, Allan M. Glanzman, Zarazuela Zolkipli-Cunningham, Amy Pasternak, Tina Duong, Sally Dunaway Young, Matthew Civitello, Chiara Marini-Bettolo, John W. Day, Basil T. Darras, Darryl C. De Vivo, Richard S. Finkel, Eugenio Mercuri, Francesco Muntoni
Summary: The study investigates the motor function of participants with Spinal Muscular Atrophy (SMA) using the Revised Hammersmith Scale (RHS), and contextualizes the findings with the Hammersmith Functional Motor Scale-Expanded (HFMSE). The transitional group, including crawlers, standers, and walkers-with-assistance, shows the most significant decline in the RHS score over a year. The study highlights the importance of considering SMA type, motor function, and baseline RHS score in interpreting the change scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Zhao Shan, Wei Hong Fa, Chen Run Tian, Chen Shi Yuan, Ning Jie
Summary: Research has shown that mitophagy plays an important role in regulating type 2 diabetes and metabolic homeostasis. Defective mitophagy is linked to the development of insulin resistance, which leads to various diseases. Restoring mitophagy can be a reliable target for treating type 2 diabetes. Recent studies have shown that certain phytochemicals can prevent dysfunction of beta-cells by inducing mitophagy.
Article
Medicine, Research & Experimental
Seth A. Berkowitz, Gina R. Kruse, Katharine A. Ball Ricks, Jessica Burch, Ethan Ouimet, Beth Kitzis, Colleen Forrest, Jean Terranova, Paul W. Stewart, John B. Buse, Thomas C. Keyserling, Deborah J. Wexler, Linda M. Delahanty
Summary: This article describes a trial protocol to assess whether medically tailored meals plus lifestyle intervention can improve hemoglobin A1c and participant-reported outcomes compared to a food subsidy for adults with both type 2 diabetes and food insecurity. The trial aims to enroll 200 participants and will use a pragmatic design with random assignment to different interventions. The primary outcome is hemoglobin A1c at 6 months. The results will inform clinical management of food insecurity in the context of type 2 diabetes.
CONTEMPORARY CLINICAL TRIALS
(2023)
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, John B. Buse, Elizabeth Selvin, Sonia Y. Angell, Vanita R. Aroda, Jessica R. Castle, Alice Y. Y. Cheng, Thomas Danne, Justin B. Echouffo-Tcheugui, Jose C. Florez, Meghana D. Gadgil, Amalia Gastaldelli, Jennifer B. Green, Ania M. Jastreboff, Alka M. Kanaya, Namratha R. Kandula, Csaba P. Kovesdy, Neda Laiteerapong, Kristen J. Nadeau, Rodica Pop-Busui, Camille E. Powe, Casey M. Rebholz, Michael R. Rickels, Naveed Sattar, Jonathan E. Shaw, Emily K. Sims, Kristina M. Utzschneider, Adrian Vella, Cuilin Zhang
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, John B. Buse, Elizabeth Selvin
Article
Endocrinology & Metabolism
Shweta Pathak, Kristina Kearin, Anna R. Kahkoska, Kathryn A. Fuller, Bradley Staats, Joseph Albright, Til Sturmer, John B. Buse, Benjamin Y. Urick
Summary: A policy change by a commercial insurer expanded coverage of continuous glucose monitoring (CGM) through the pharmacy benefit, leading to increased utilization of CGM. The study found that CGM use significantly increased after the policy change, especially among type 1 diabetes mellitus (T1DM) patients. The findings suggest that the policy change had a positive impact on CGM utilization.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Elena Casiraghi, Rachel Wong, Margaret Hall, Ben Coleman, Marco Notaro, Michael D. Evans, Jena S. Tronieri, Hannah Blau, Bryan Laraway, Tiffany J. Callahan, Lauren E. Chan, Carolyn T. Bramante, John B. Buse, Richard A. Moffitt, Til Sturmer, Steven G. Johnson, Yu Raymond Shao, Justin Reese, Peter N. Robinson, Alberto Paccanaro, Giorgio Valentini, Jared D. Huling, Kenneth J. Wilkins
Summary: Healthcare datasets from Electronic Health Records are valuable for assessing associations between patients' predictors and outcomes. However, missing values are common in these datasets, and removing them may introduce bias. Multiple imputation algorithms have been proposed to recover missing information, but there is no consensus on which algorithm works best. Choosing algorithm parameters and data-related modeling choices is also challenging.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, Mark A. Atkinson, George L. Bakris, John B. Buse, Frank B. Hu, Stephen S. Rich, Matthew C. Riddle, Elizabeth Selvin
Article
Endocrinology & Metabolism
John B. Buse, Helene Nordahl Christensen, Brian J. Harty, Julie Mitchell, Benjamin P. Soule, Emily Zacherle, Mark Cziraky, Vincent J. Willey
Summary: SEPRA is an ongoing pragmatic clinical trial that aims to compare the effects of once-weekly subcutaneous semaglutide with standard care in patients with type 2 diabetes. It collects data from routine clinical practice to support decision-making by clinicians, payers, and policy makers. Key outcomes of the study include glycemic control, weight loss, healthcare utilization, and patient-reported outcomes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Biographical-Item
Endocrinology & Metabolism
Steven E. Kahn, Michael W. Schwartz
Article
Medicine, Research & Experimental
Jessica A. Regan, Robert J. Mentz, Maggie Nguyen, Jennifer B. Green, Lauren K. Truby, Olga Ilkayeva, Christopher B. Newgard, John B. Buse, Harald Sourij, C. David Sjostrom, Naveed Sattar, Robert W. Mcgarrah, Yinggan Zheng, Darren K. Mcguire, Eberhard Standl, Paul Armstrong, Eric D. Peterson, Adrian F. Hernandez, Rury R. Holman, Svati H. Shah
Summary: This study reveals the heterogeneity of major adverse cardiovascular event (MACE) risk in individuals with type 2 diabetes mellitus (T2D) and identifies circulating metabolites reflecting mitochondrial dysfunction that can predict incident MACE. These metabolites remain associated with MACE in multivariate models and show favorable changes with exenatide therapy. The findings suggest that these biomarkers may improve cardiovascular risk prediction models and highlight emerging risk mechanisms.
Article
Psychology, Clinical
Larissa Vierl, Susanne Hoerz-Sagstetter, Cord Benecke, Carsten Spitzer, Florian Juen
Summary: This study compares two widely used questionnaires based on psychodynamic theories for assessing personality functioning (PF), finding that while highly correlated, they tap into distinct domains of PF. Exploratory Graph Analysis (EGA) and bootEGA were used to explore the dimensionality and stability of the questionnaires. These findings have important implications for clinical and scientific practice.
JOURNAL OF PERSONALITY ASSESSMENT
(2023)
Article
Medicine, Research & Experimental
Nandini Avula, Dustin Kakach, Christopher J. Tignanelli, David M. Liebovitz, Jacinda M. Nicklas, Kenneth Cohen, Michael A. Puskarich, Hrishikesh K. Belani, John B. Buse, Nichole R. Klatt, Blake Anderson, Amy B. Karger, Katrina M. Hartman, Barkha Patel, Sarah L. Fenno, Neha V. Reddy, Spencer M. Erickson, David R. Boulware, Thomas A. Murray, Carolyn T. Bramante
Summary: The COVID-19 pandemic has led to the advancement of decentralized clinical trials (DCT). DCTs have proved to be an effective and pragmatic method for assessing health outcomes during the pandemic. This report highlights the successful implementation of the COVID-OUT trial, which utilized decentralized strategies to rapidly deliver study drugs and remotely monitor participant outcomes.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Lauren E. Dang, Edwin Fong, Jens Magelund Tarp, Kim Katrine Bjerring Clemmensen, Henrik Ravn, Kajsa Kvist, John B. Buse, Mark van der Laan, Maya Petersen
Summary: This study presents three designs for evaluating the difference in risk of major adverse cardiovascular events between oral semaglutide and standard-of-care. Simulation results show that Designs 1 and 2 perform similarly, while Design 3 integrates external controls in 84% of cross-validation folds. The estimated risk difference using Design 3 is -1.53%-points.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Mustafa Tosur, Laura Gandolfo, Ashok Balasubramanyam, Rochelle N. Naylor, Toni I. Pollin, Neda Rasouli, Sara J. Cromer, John B. Buse, Maria J. Redondo
Summary: The incidence of diabetes in underrepresented racial and ethnic groups is increasing and has worse outcomes compared to non-Hispanic White individuals. This study aimed to recruit a diverse study population, however, the participation of underrepresented groups was low. Strategies to enhance their recruitment and retention are needed.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)