Article
Endocrinology & Metabolism
Caitlin W. Hicks, Dan Wang, Kunihiro Matsushita, John W. McEvoy, Robert Christenson, Elizabeth Selvin
Summary: This study evaluated the associations between two biomarkers of hyperglycemia (HbA1c and glycated albumin) and lower extremity disease in adults, finding significant associations in adults with diabetes. The study highlights the importance of diabetes prevention and glycemic control in reducing the burden of lower extremity disease.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sara Hallstrom, Ann-Marie Svensson, Aldina Pivodic, Arndis F. Olafsdottir, Magnus Londahl, Hans Wedel, Marcus Lind
Summary: The incidence of lower extremity amputations in people with type 1 diabetes has decreased over time in Sweden, with major risk factors being hyperglycemia and renal dysfunction.
Article
Medicine, General & Internal
Min Jun Seo, Dong Geon Lee, Se Yun Ko, Ga Yeong Song, Geon Yeong Lee, Sung Hwa Kim, Dae Ryong Kang, Jiye Kim, Jun Young Lee
Summary: Patients with end-stage kidney disease on dialysis are at a high risk of developing foot ulcerations and subsequent lower extremity amputation. Identifying risk factors associated with amputation can help predict and prevent its progression. Factors such as older age, male gender, lower income, non-metropolitan residence, diabetes mellitus, dialysis treatment, microvascular disease, peripheral vascular disease, endovascular procedure, and endovascular operation are associated with an increased risk of amputation. Close monitoring and consideration of kidney transplantation as a preventative measure are recommended for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Spela Zerovnik, Mitja Kos, Igor Locatelli
Summary: The study compared the influence of SGLT2i and DPP-4i on the risk of lower extremity amputations in patients with type 2 diabetes in Slovenia. The results suggest that SGLT2i may increase the risk of amputation with long-term use.
ACTA DIABETOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Mariam Bapir, Gavrielle R. Untracht, Debbie Cooke, John H. McVey, Simon S. Skene, Paola Campagnolo, Martin B. Whyte, Nikolaos Dikaios, Ana Rodriguez-Mateos, David D. Sampson, Danuta M. Sampson, Christian Heiss
Summary: This study found that individuals with type 2 diabetes mellitus (T2DM) exhibit greater impairment in femoral artery endothelial function and dermal microcirculation. The consumption of cocoa flavanol (CF) improves endothelial function in both healthy individuals and those with T2DM, who are at increased risk of developing lower extremity peripheral artery disease (PAD) and foot ulcers.
Article
Cardiac & Cardiovascular Systems
Sarah O'Connor, Claudia Blais, Jacinthe Leclerc, Jeremie Sylvain-Morneau, Elhadji Anassour Laouan Sidi, Denis Hamel, Laura Drudi, Nathalie Gilbert, Paul Poirier
Summary: This study aimed to document the trends of primary lower extremity amputations (LEAs) in Quebec, Canada from 2006 to 2019. The results showed a decrease in the incidence of major LEAs, but an increase in the absolute number of cases. Additionally, there was an increase in minor LEAs among younger age groups, highlighting the importance of further improving preventive care.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Edward J. Boyko, Leila R. Zelnick, Barbara H. Braffett, Rodica Pop-Busui, Catherine C. Cowie, Gayle M. Lorenzi, Rose Gubitosi-Klug, Bernard Zinman, Ian H. de Boer
Summary: Intensive glycemic control reduces the risk of diabetic foot ulcers, which is an important precursor to lower-extremity amputations in type 1 diabetes patients.
Article
Endocrinology & Metabolism
Edward J. Boyko, Leila R. Zelnick, Barbara H. Braffett, Rodica Pop-Busui, Catherine C. Cowie, Gayle M. Lorenzi, Rose Gubitosi-Klug, Bernard Zinman, Ian H. de Boer
Summary: The study demonstrates that early intensive glycemic control significantly reduces the risk of diabetic foot ulcers in type 1 diabetes patients, which is the most important antecedent in causing lower-extremity amputations.
Article
Medicine, General & Internal
Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Javier de Miguel-Diez, Jose M. de Miguel-Yanes, Ricardo Omana-Palanco, David Carabantes-Alarcon
Summary: This study examined trends in the incidence, clinical characteristics, and in-hospital outcomes of lower-extremity amputations among individuals with type 2 diabetes in Spain. The study also assessed possible sex differences in these outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Patrick Lauwers, Kristien Wouters, Johan Vanoverloop, Herve Avalosse, Jeroen M. H. Hendriks, Frank Nobels, Eveline Dirinck
Summary: This study assessed the impact of diabetes, amputation level, sex, and age on mortality rates after lower extremity amputation (LEA) in Belgium from 2009 to 2018, and evaluated the trends in one-year survival rates. The study found that individuals with diabetes had higher mortality rates after LEA, particularly after six months post-surgery. Compared to individuals with diabetes but without amputation, mortality rates were lower in amputees.
Article
Cardiac & Cardiovascular Systems
Ariel Fangting Ying, Tjun Yip Tang, Aizhen Jin, Tze Tec Chong, Derek John Hausenloy, Woon-Puay Koh
Summary: Patients with diabetes have a significantly increased risk of lower extremity amputation (LEA) due to chronic limb-threatening ischemia (CLTI). However, hypertension and increased BMI do not further increase LEA risk among those with diabetes, suggesting a common mechanistic pathway for these risk factors. In contrast, smoking may act via an alternative pathway and confer additional risk regardless of diabetes status.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Javier de-Miguel-Diez, Jose M. de-Miguel-Yanes, Ricardo Omana-Palanco, David Carabantes-Alarcon
Summary: The study found a decrease in the incidence rates of minor and major lower extremity amputations (LEAs) among both men and women with type 1 diabetes mellitus (T1DM). However, in the last two years of the study, there was a slight increase in the incidence of major LEAs in men with T1DM, although this increase was not significant. The incidence of both minor and major LEAs was higher in men compared to women. Female sex was associated with a higher in-hospital mortality (IHM) following major LEAs.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Linru Wang, Qjang Li, Xiao Chen, Zhaowei Wang
Summary: This study aimed to investigate the risk factors of lower limb amputation in patients with diabetic foot. The results showed that male sex, larger ulcer size, higher grade of Wagner classification, peripheral arterial disease and osteomyelitis were independent risk factors for lower limb amputation in these patients.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Surgery
Jacob Buckner, John Cabot, Alyssa Fields, Lori Pounds, Clay Quint
Summary: This study evaluated the accuracy of multiple risk calculators for 30-day mortality on patients undergoing major lower extremity amputation. The VASQIP and POTTER elective risk calculators showed similar calculated 30-day mortality to the actual mortality, while the NSQIP and AST over-estimated the mortality. The predictive accuracy of the POTTER and NSQIP risk calculators were moderate, while it was fair for VASQIP and AST.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Economics
Yixue Shao, Charles Stoecker, Dongzhe Hong, Elizabeth Nauman, Vivian Fonseca, Gang Hu, Alessandra N. Bazzano, Edmond K. Kabagambe, Lizheng Shi
Summary: This study evaluated the impact of reimbursement for non-face-to-face chronic care management on healthcare utilization among Medicare beneficiaries with type 2 diabetes in Louisiana. The results showed that receiving non-face-to-face chronic care management was associated with increased outpatient visits and decreased inpatient admissions and emergency department visits. In the future, the cost savings of non-face-to-face chronic care management in diabetes management could be further explored.
Article
Sport Sciences
Catarina L. Nunes, Gil B. Rosa, Filipe Jesus, Steven B. Heymsfield, Claudia S. Minderico, Paulo Martins, Luis B. Sardinha, Analiza M. Silva
Summary: This study aimed to investigate the occurrence of adaptive thermogenesis in non-exercise activity thermogenesis (NEAT) after weight loss (WL) and understand the associations of these compensations with weight loss. The study found no significant differences in NEAT or non-exercise physical activity (NEPA) after the WL intervention, indicating that compensatory changes in these activities may not play a significant role in weight loss.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Peter T. Katzmarzyk, Emily F. J. Mire, Corby K. A. Martin, Robert L. K. Newton, John W. Apolzan, Kara D. B. Denstel, William D. F. Johnson, PROPEL Res Grp
Summary: The purpose of this study was to determine the association between changes in physical activity and changes in body weight in a cluster-randomized weight loss trial conducted in an underserved population in Louisiana. This study reports analyses conducted in the intervention group only, which was a 24-month multi-component weight loss program delivered by health coaches embedded in primary care clinics. The results showed that greater increases in physical activity over the intervention period were associated with greater percent reductions in body weight.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Gang Hu, Jonathan Ding, Donna H. Ryan
Summary: This study analyzed the trends in obesity prevalence and control of cardiometabolic risk factors among people with diabetes from 1999 to 2020. The results showed that the prevalence of obesity increased over time, while the percentage of people with glycemic control decreased. However, there was an improvement in blood pressure control and lipid control. Participants with obesity had worse glycemic control and lipid control compared to those with normal weight.
Article
Pediatrics
Ming Gao, Hui Wang, Weiqin Li, Leishen Wang, Ninghua Li, Yijuan Qiao, Tao Zhang, Jing Li, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang
Summary: This study found that both maternal insulin resistance and beta-cell dysfunction at diagnosis of gestational diabetes mellitus (GDM) were associated with an increased risk of offspring overweight within 24 months of age among Chinese women.
Article
Endocrinology & Metabolism
Ming Gao, Hui Wang, Weiqin Li, Ping Shao, Ninghua Li, Jinnan Liu, Peng Wang, Shuang Zhang, Jing Li, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang
Summary: There is a relationship between parental obesity before pregnancy and offspring overweight before the age of two among children of Chinese women with gestational diabetes mellitus (GDM). A study in China followed up with 774 offspring of women diagnosed with GDM from 2010-2012 until the age of two. The study found that maternal obesity before pregnancy was associated with an increased risk of offspring overweight at 1-1.5 years and 1.5-2 years of age, while paternal obesity before pregnancy was only associated with an elevated risk of offspring overweight at 1.5-2 years of age. The presence of both maternal and paternal obesity had an additive effect on the risk of offspring overweight at 1.5-2 years of age.
PRIMARY CARE DIABETES
(2023)
Article
Nutrition & Dietetics
Rebecca J. J. Deyell, Sunil Desai, Andrea Gallivan, Alecia Lim, Michael B. B. Sawyer, Steven B. B. Heymsfield, Wei Shen, Vickie E. E. Baracos
Summary: This study established models to predict the whole-body skeletal muscle and fat composition in pediatric oncology patients using cross-sectional abdominal images, and analyzed a previously recruited cohort of healthy children using whole-body MRI, showing high correlation. The results indicate that cross-sectional area data can be used to predict the whole-body skeletal muscle and fat composition in pediatric patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Nicholas Ashby, G. Jake LaPorte, Daniel Richardson, Michael Scioletti, Steven B. Heymsfield, John A. Shepherd, Michael McGurk, Brenda Bustillos, Nicholas Gist, Diana M. Thomas
Summary: Mathematical models have been developed to translate anthropometric measurements between three popular commercially available scanners, allowing for standardized data pooling and comparison.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Manfred J. Mueller, Steven B. Heymsfield, Anja Bosy-Westphal
Summary: Adaptive thermogenesis is the mass-independent decrease in energy expenditure during caloric restriction and weight loss, which persists during weight maintenance. It occurs in resting and nonresting energy expenditure as AT(REE) and AT(NREE), respectively. AT(REE) has different mechanisms in different phases of weight loss, while AT(NREE) exceeds AT(REE) during weight maintenance. Some mechanisms of AT are known, but others remain unknown. Future studies on AT require an appropriate conceptual framework for experiment design and result interpretation.
Biographical-Item
Anthropology
Peter T. Katzmarzyk, Claude Bouchard
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Anthropology
Sara Pereira, Peter T. Katzmarzyk, Donald Hedeker, Tiago V. Barreira, Rui Garganta, Claudio Farias, Fernando Garbeloto, Go Tani, Jean-Philippe Chaput, David F. Stodden, Jose Maia
Summary: The REACT project aims to assess children's growth and motor development after the COVID-19 pandemic and track their fundamental movement skills' developmental trajectories using a novel technological device. The study involves 1000 children aged 6-10 from primary schools in Matosinhos, Portugal, and examines variables related to the child, family, school, and home environment. The results will provide valuable information for school administrators, teachers, and parents regarding children's growth, motor development, and health.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Steven B. Heymsfield, Shengping Yang, Cassidy McCarthy, Jasmin B. Brown, Corby K. Martin, Leanne M. Redman, Eric Ravussin, Wei Shen, Manfred J. Mueller, Anja Bosy-Westphal
Summary: The objective of this study was to develop models to predict the reduction in skeletal muscle mass during periods of voluntary calorie restriction and to validate the predictions in longitudinally monitored samples. The results showed that nonelderly males and females with overweight and obesity experience respective reductions in skeletal muscle mass with voluntary calorie restriction, with males losing approximately 2 to 2.5 kg and females losing approximately 1 to 1.5 kg of muscle mass per 10 kg of weight loss.
Article
Health Care Sciences & Services
Siddharth Choudhary, Ganesh Iyer, Brandon M. Smith, Jinjin Li, Mark Sippel, Antonio Criminisi, Steven B. Heymsfield
Summary: An accurate and reliable smartphone application, MeasureNet, based on novel computer vision algorithms, has been developed for estimating waist-to-hip circumference ratio (WHR) in adults. This application uses front, side, and back color images to predict a person's body circumferences and WHR through a convolutional neural network model. It fills a gap by providing convenient and accurate WHR measurements, bridging the inconsistencies of self-measurements at home and measurements conducted in clinical environments.
NPJ DIGITAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Arao Belitardo de Oliveira, Peter T. Katzmarzyk, Wagner Silva Dantas, Isabela Judith Martins Bensenor, Alessandra de Carvalho Goulart, Ulf Ekelund
Summary: This study examined the prevalence of leisure-time physical activity and sedentary behavior in Brazilian adults and found that the majority of adults in Brazil are physically inactive and do not meet international recommendations.
EPIDEMIOLOGIA E SERVICOS DE SAUDE
(2023)
Article
Anthropology
Jean-Philippe Chaput, Sara Pereira, Peter T. Katzmarzyk, Donald Hedeker, Tiago V. Barreira, Rui Garganta, Claudio Farias, Fernando Garbeloto, Go Tani, David F. Stodden, Jose Maia
Summary: This study aimed to examine the association between sleep characteristics and fundamental movement skills (FMS) proficiency levels in school-aged children. The results, based on a sample of 996 children, showed that sleep characteristics were not related to FMS proficiency levels. However, being a boy, older age, and higher physical activity levels were significantly associated with better FMS proficiency.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
